β-Actin Rabbit pAb (AC006)

Western blot analysis of various lysates using β-Actin Rabbit pAb (AC006) at 1:1000 dilution.Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (RM00020).Exposure time: 1s.

All(1)|

货号: AC006

详细信息

推荐稀释比

WB1:500 - 1:1000

浓度查询

请输入产品标签上的lot号，例如4000000001

反应物种

Human, Mouse, Rat

同种型

IgG

理论分子量

42kDa

实际分子量

42kDa

产品形式

Liquid

偶联物

Unconjugated

存储缓冲液

Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.

阳性样本

HeLa,MCF7,A-431,NIH/3T3,C6,Mouse testis,Mouse kidney,Rat testis

细胞定位

Cytoplasm,cytoskeleton.

纯化方式

Affinity purification

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用户验证的应用

应用及物种

WB (MSC cellsHomo sapiens , Mus musculus , Mus musculus , Rattus norvegicus , Homo sapiens , Arabidopsis thaliana , Homo sapiens , Rattus norvegicus , Tree , Flowers , Melodinus cochinchinensis , Sus scrofa , flounder , Verticillium dahliae , Gallus gallus , Other , Lampetra japonica , Crassostrea gigas , Anser cygnoides)
IF (Homo sapiens , Rattus norvegicus , Homo sapiens , Mus musculus)
IP (Mus musculus , Homo sapiens)
qRT-PCR (Homo sapiens , Mus musculus)

客户数据及评论 (1)

折叠内容

CustomerSep 022018

评分
Experiment Type: Western blot (WB)
Sample: MSC cells
Description: Western blot analysis of extracts of MSC cells, using antibody at 1:1000 dilution.

文献引用 (149)

折叠内容

Publishing research using AC006? Please let us know so that we can cite the reference in this datasheet.

Structures of sperm flagellar doublet microtubules expand the genetic spectrum of male infertility

Journal

Cell

Published

2023

Application

IF:

66.85

Species

Homo sapiens, Mus musculus

PMID

37295417

Histone demethylase KDM3A is required for enhancer activation of hippo target genes in colorectal cancer.

Journal

Nucleic acids research

Published

2019

Application

19.16

Species

Mus musculus

PMID

30649550

The KLF7/PFKL/ACADL axis modulates cardiac metabolic remodelling during cardiac hypertrophy in male mice - PMC

Journal

Nature communications

Published

2023

Application

17.69

Species

Mus musculus

PMID

36810848

Cardiac patches made of brown adipose-derived stem cell sheets and conductive electrospun nanofibers restore infarcted heart for ischemic myocardial infarction - PMC

Journal

Bioactive materials

Published

2023

Application

16.87

Species

Rattus norvegicus

PMID

37122901

Self-renewal or quiescence? Orchestrating the fate of mesenchymal stem cells by matrix viscoelasticity via PI3K/Akt-CDK1 pathway

Journal

Biomaterials

Published

2021

Application

IF:

15.304

Species

Rattus norvegicus

PMID

34749070

Eubacterium coprostanoligenes alleviates chemotherapy-induced intestinal mucositis by enhancing intestinal mucus barrier

Journal

Acta pharmaceutica Sinica. B

Published

2023

Application

14.5

Species

Mus musculus

PMID

38572095

Cleaved SPP1-rich extracellular vesicles from osteoclasts promote bone regeneration via TGF1/SMAD3 signaling

Journal

Biomaterials

Published

2023

Application

IF:

Species

Homo sapiens

PMID

38465579

Autophagy contributes to sulfonylurea herbicide tolerance via GCN2-independent regulation of amino acid homeostasis.

Journal

Autophagy

Published

2017

Application

IF:

13.391

Species

Arabidopsis thaliana

PMID

29377765

The presence of blastocyst within the uteri facilitates lumenal epithelium transformation for implantation via upregulating lysosome proteostasis activity

Journal

Autophagy

Published

2023

Application

IF:

13.39

Species

Mus musculus

PMID

37584546

Porcine reproductive and respiratory syndrome virus degrades DDX10 via SQSTM1/p62-dependent selective autophagy to antagonize its antiviral activity

Journal

Autophagy

Published

2023

Application

IF:

13.39

Species

Homo sapiens

PMID

36779599

Intravital molecular imaging reveals that ROS-caspase-3-GSDME-induced cell punching enhances humoral immunotherapy targeting intracellular tumor antigens - PMC

Journal

Theranostics

Published

2022

Application

IF:

11.6

Species

Mus musculus

PMID

36438480

Efficacy-shaping nanomedicine by loading Calcium Peroxide into Tumor Microenvironment-responsive Nanoparticles for the Antitumor Therapy of Prostate Cancer

Journal

Theranostics

Published

2020

Application

IF:

11.6

Species

Mus musculus

PMID

32863961

TrxR1 is involved in the activation of Caspase-11 by regulating the oxidative-reductive status of Trx-1 - PMC

Journal

Redox biology

Published

2024

Application

IF:

11.4

Species

Mus musculus

PMID

39059206

NFATc1-mediated expression of SLC7A11 drives sensitivity to TXNRD1 inhibitors in osteoclast precursors

Journal

Redox biology

Published

2023

Application

IF:

10.78

Species

Mus musculus

PMID

37148740

Stearoyl-CoA Desaturase-1 dependent lipid droplets accumulation in cancer-associated fibroblasts facilitates the progression of lung cancer - PMC

Journal

International journal of biological sciences

Published

2022

Application

10.75

Species

Mus musculus

PMID

36439884

Value added immunoregulatory polysaccharides of Hericium erinaceus and their effect on the gut microbiota

Journal

Carbohydr Polym .

Published

2021

Application

10.723

Species

Mus musculus

PMID

33838836

m6A methylation-induced NR1D1 ablation disrupts the HSC circadian clock and promotes hepatic fibrosis

Journal

Pharmacological research

Published

2023

Application

10.33

Species

Homo sapiens, Mus musculus

PMID

36813093

Mesenchymal stem cells ameliorate hyperglycemia-induced endothelial injury through modulation of mitophagy.

Journal

Cell death & disease

Published

2018

Application

WB, IF

9.685

Species

Homo sapiens, Rattus norvegicus

PMID

30082798

Mesenchymal stem cell-derived exosomal miR-27b-3p alleviates liver fibrosis via downregulating YAP/LOXL2 pathway - PMC

Journal

Journal of nanobiotechnology

Published

2023

Application

9.42

Species

Homo sapiens

PMID

37328872

FBL promotes cancer cell resistance to DNA damage and BRCA1 transcription via YBX1

Journal

EMBO reports

Published

2023

Application

IF:

9.07

Species

Mus musculus

PMID

37489617

Epstein-Barr Virus Early Protein BFRF1 Suppresses IFN-β Activity by Inhibiting the Activation of IRF3

Journal

Front Immunol

Published

2020

Application

IF:

8.786

Species

Homo sapiens

PMID

33391252

The transcription factor GATA3 is required for homologous recombination repair by regulating CtIP expression

Journal

Oncogene

Published

2017

Application

IF:

8.756

Species

Homo sapiens

PMID

28481869

Pan-histone deacetylase inhibitor vorinostat suppresses osteoclastic bone resorption through modulation of RANKL-evoked signaling and ameliorates ovariectomy-induced bone loss - PMC

Journal

Cell communication and signaling : CCS

Published

2024

Application

8.4

Species

Mus musculus

PMID

38439009

Supplementation of nicotinamide mononucleotide diminishes COX-2 associated inflammatory responses in macrophages by activating kynurenine/AhR signaling

Journal

Free radical biology & medicine

Published

2024

Application

8.1

Species

Mus musculus

PMID

38336100

Notoginsenoside R1 alleviates cerebral ischemia/reperfusion injury by inhibiting the TLR4/MyD88/NF-B signaling pathway through microbiota-gut-brain axis

Journal

Phytomedicine : international journal of phytotherapy and phytopharmacology

Published

2024

Application

7.9

Species

Rattus norvegicus

PMID

38493723

Notoginsenoside Fc, a Novel Renoprotective Agent, Ameliorates Glomerular Endothelial Cells Pyroptosis and Mitochondrial Dysfunction in Diabetic Nephropathy

Journal

Phytomedicine : international journal of phytotherapy and phytopharmacology

Published

2024

Application

7.9

Species

Mus musculus

PMID

38412666

Discovery of Novel Pterostilbene Derivatives That Might Treat Sepsis by Attenuating Oxidative Stress and Inflammation through Modulation of MAPKs/NF-κB Signaling Pathways

Journal

Antioxidants (Basel)

Published

2021

Application

7.675

Species

Mus musculus

PMID

34572964

Post-treatment with Resolvin D1 attenuates pulmonary hypertension by inhibiting endothelial-to-mesenchymal transition

Journal

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Published

2024

Application

7.5

Species

Homo sapiens,Mus musculus

PMID

38908199

Dendrobium officinale regulate lipid metabolism in diabetic mouse liver via PPAR-RXR signaling pathway: Evidence from an integrated multi-omics analysis

Journal

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Published

2024

Application

7.5

Species

Mus musculus

PMID

38460364

Cordycepin inhibits myogenesis via activating the ERK1/2 MAPK signalling pathway in C2C12 cells

Journal

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Published

2023

Application

7.41

Species

Mus musculus

PMID

37453196

Ca2+-dependent nuclease is involved in DNA degradation during the formation of the secretory cavity by programmed cell death in fruit of Citrus grandis 'Tomentosa'

Journal

J Exp Bot

Published

2020

Application

IF:

7.298

Species

Tree,Flowers

PMID

32324220

In vitro evaluation of nanoplastics using human lung epithelial cells, microarray analysis and co-culture model

Journal

Ecotoxicol Environ Saf

Published

2021

Application

7.129

Species

Homo sapiens

PMID

34619472

Procyanidins inhibit fine particulate matter-induced vascular smooth muscle cells apoptosis via the activation of the Nrf2 signaling pathway

Journal

Ecotoxicol Environ Saf

Published

2021

Application

7.129

Species

Rattus norvegicus

PMID

34364126

TGR5-HNF4α axis contributes to bile acid-induced gastric intestinal metaplasia markers expression

Journal

Cell Death Discov

Published

2020

Application

7.109

Species

Homo sapiens

PMID

32655894

CB2 regulates oxidative stress and osteoclastogenesis through NOX1-dependent signaling pathway in titanium particle-induced osteolysis - PMC

Journal

Cell death discovery

Published

2023

Application

7.1

Species

Mus musculus

PMID

38104087

Construction of Coxsackievirus B5 viruses with luciferase reporters and their applications in vitro and in vivo

Journal

Virologica Sinica

Published

2023

Application

6.94

Species

Homo sapiens

PMID

37244518

GYY4137 alleviates sepsis-induced acute lung injury in mice by inhibiting the PDGFRβ/Akt/NF-κB/NLRP3 pathway

Journal

Life Sci

Published

2021

Application

IF:

6.78

Species

Mus musculus

PMID

33577850

Identification of GL-V9 as a novel senolytic agent against senescent breast cancer cells

Journal

Life Sci

Published

2021

Application

IF:

6.78

Species

Mus musculus

PMID

33617857

Celastrol attenuates incision-induced inflammation and pain associated with inhibition of the NF-κB signalling pathway via SARM

Journal

Life Sciences

Published

2018

Application

IF:

6.78

Species

Rattus norvegicus

PMID

29750991

Purslane (Portulacae oleracea L.) attenuates cadmium-induced hepatorenal and colonic damage in mice: Role of chelation, antioxidant and intestinal microecological regulation

Journal

Phytomedicine

Published

2021

Application

IF:

6.656

Species

Mus musculus

PMID

34481339

Chemical constituents and anti-inflammatory activity of the total alkaloid extract from Melodinus cochinchinensis (Lour.) Merr. and its inhibition of the NF-κB and MAPK signaling pathways

Journal

Phytomedicine

Published

2021

Application

IF:

6.656

Species

Melodinus cochinchinensis

PMID

34400050

Intestinal metabolite UroB alleviates cerebral ischemia/reperfusion injury by promoting competition between TRIM65 and TXNIP for binding to NLRP3 inflammasome

Journal

Biochimica et biophysica acta. Molecular basis of disease

Published

2024

Application

6.63

Species

Rattus norvegicus

PMID

38360072

Glutamine mitigates oxidative stress-induced matrix degradation, ferroptosis, and pyroptosis in nucleus pulposus cells via deubiquitinating and stabilizing Nrf2

Journal

Antioxidants & redox signaling

Published

2024

Application

6.6

Species

Rattus norvegicus

PMID

38504579

Porcine Epidemic Diarrhea Virus nsp7 Inhibits Interferon-Induced JAK-STAT Signaling through Sequestering the Interaction between KPNA1 and STAT1

Journal

Journal of virology

Published

2022

Application

WB, IP

6.54

Species

Mus musculus

PMID

35442061

Chitosan Oligosaccharides Alleviate H 2 O 2 -stimulated Granulosa Cell Damage via HIF-1 α Signaling Pathway

Journal

Oxidative medicine and cellular longevity

Published

2022

Application

6.54

Species

Homo sapiens

PMID

35401926

Gramicidin inhibits cholangiocarcinoma cell growth by suppressing EGR4

Journal

Artificial cells, nanomedicine, and biotechnology

Published

2020

Application

6.355

Species

Homo sapiens

PMID

31852273

Ganoderic acid improves 5-fluorouracil-induced cognitive dysfunction in mice

Journal

Food Funct

Published

2021

Application

IF:

6.317

Species

Mus musculus

PMID

34821902

Cholesterol 25-hydroxylase suppresses porcine deltacoronavirus infection by inhibiting viral entry

Journal

Virus Res

Published

2021

Application

IF:

6.286

Species

Sus scrofa

PMID

33476696

Phosphatase and Tensin Homolog (PTEN) of Japanese Flounder-Its Regulation by miRNA and Role in Autophagy, Apoptosis and Pathogen Infection

Journal

Int J Mol Sci

Published

2020

Application

IF:

6.208

Species

flounder

PMID

33086544

Ameliorating Effects of Vitamin K2 on Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice - PMC

Journal

International journal of molecular sciences

Published

2023

Application

6.2

Species

Mus musculus

PMID

36769323

MLL5 is involved in retinal photoreceptor maturation through facilitating CRX-mediated photoreceptor gene transactivation

Journal

iScience

Published

2022

Application

IF:

6.107

Species

Homo sapiens, Mus musculus

PMID

35359806

Gasdermin D promotes hyperuricemia-induced renal tubular injury through RIG-I/caspase-1 pathway - PMC

Journal

iScience

Published

2023

Application

IF:

6.1

Species

Rattus norvegicus

PMID

38187191

Spatiotemporal Expression of SphK1 and S1PR2 in the Hippocampus of Pilocarpine Rat Model and the Epileptic Foci of Temporal Lobe Epilepsy

Journal

Front Cell Dev Biol

Published

2020

Application

6.081

Species

Rattus norvegicus

PMID

33134289

Distinct Roles of TRAPPC8 and TRAPPC12 in Ciliogenesis via Their Interactions With OFD1

Journal

Frontiers in Cell and Developmental Biology

Published

2020

Application

6.081

Species

Homo sapiens

PMID

32258032

Porcine Deltacoronavirus Accessory Protein NS7a Antagonizes IFN-β Production by Competing With TRAF3 and IRF3 for Binding to IKKε

Journal

Front Cell Infect Microbiol

Published

2020

Application

6.073

Species

Sus scrofa

PMID

32656094

Thioredoxin VdTrx1, an unconventional secreted protein, is a virulence factor in Verticillium dahliae - PMC

Journal

Frontiers in microbiology

Published

2023

Application

6.06

Species

Verticillium dahliae

PMID

37065139

Astragalus polysaccharides alleviates lipopolysaccharides-induced inflammatory lung injury by altering intestinal microbiota in mice - PMC

Journal

Frontiers in microbiology

Published

2022

Application

6.06

Species

Mus musculus

PMID

36386641

-Caryophyllene Ameliorates MSU-Induced Gouty Arthritis and Inflammation Through Inhibiting NLRP3 and NF-B Signal Pathway: In Silico and In Vivo

Journal

Front Pharmacol

Published

2021

Application

IF:

5.988

Species

Rattus norvegicus

PMID

33967792

Loureirin B Exerts its Immunosuppressive Effects by Inhibiting STIM1/Orai1 and K V 1.3 Channels

Journal

Front Pharmacol

Published

2021

Application

IF:

5.988

Species

Homo sapiens

PMID

34248635

Squamosamide Derivative FLZ Diminishes Aberrant Mitochondrial Fission by Inhibiting Dynamin-Related Protein 1

Journal

Front Pharmacol

Published

2021

Application

IF:

5.988

Species

Rattus norvegicus

PMID

33815098

Crizotinib and Sunitinib Induce Hepatotoxicity and Mitochondrial Apoptosis in L02 Cells via ROS and Nrf2 Signaling Pathway

Journal

Front Pharmacol

Published

2021

Application

IF:

5.988

Species

Mus musculus

PMID

33597889

Bakuchiol Attenuates Oxidative Stress and Neuron Damage by Regulating Trx1/TXNIP and the Phosphorylation of AMPK After Subarachnoid Hemorrhage in Mice.

Journal

Frontiers in Pharmacology

Published

2020

Application

5.988

Species

Mus musculus

PMID

32499702

Melatonin-related dysfunction in chronic restraint stress triggers sleep disorders in mice - PMC

Journal

Frontiers in pharmacology

Published

2023

Application

5.98

Species

Mus musculus

PMID

37408758

POT1 inhibits the efficiency but promotes the fidelity of nonhomologous end joining at non-telomeric DNA regions

Journal

Aging

Published

2017

Application

IF:

5.955

Species

Homo sapiens

PMID

29227966

Acetate Upregulates GPR43 Expression and Function via PI3K-AKT-SP1 Signaling in Mammary Epithelial Cells during Milk Fat Synthesis

Journal

Journal of agricultural and food chemistry

Published

2023

Application

5.89

Species

Mus musculus

PMID

37870996

AT1R autoantibody promotes phenotypic transition of smooth muscle cells by activating AT1R-OAS2

Journal

Biochemical pharmacology

Published

2023

Application

5.8

Species

Rattus norvegicus

PMID

38092283

Polystyrene microplastics mediate inflammatory responses in the chicken thymus by Nrf2/NF-κB pathway and trigger autophagy and apoptosis

Journal

Environmental toxicology and pharmacology

Published

2023

Application

5.78

Species

Gallus gallus

PMID

37127111

Byakangelicol suppresses TiPs-stimulated osteoclastogenesis and bone destruction via COX-2/NF-B signaling pathway

Journal

Regenerative biomaterials

Published

2023

Application

5.76

Species

Mus musculus

PMID

38173778

An Insight on the Pathways Involved in Crizotinib and Sunitinib Induced Hepatotoxicity in HepG2 Cells and Animal Model

Journal

Frontiers in oncology

Published

2022

Application

5.738

Species

Mus musculus

PMID

35155225

Verteporfin Is a Promising Anti-Tumor Agent for Cervical Carcinoma by Targeting Endoplasmic Reticulum Stress Pathway

Journal

Front Oncol

Published

2020

Application

IF:

5.738

Species

Homo sapiens

PMID

33014875

Screening of immunotherapy-related genes in bladder cancer based on GEO datasets - PMC

Journal

Frontiers in oncology

Published

2023

Application

5.73

Species

Homo sapiens

PMID

37274283

YTHDF3 phase separation regulates HSPA13dependent clear cell renal cell carcinoma development and immune evasion

Journal

Cancer science

Published

2024

Application

IF:

5.7

Species

Homo sapiens

PMID

38811341

USF1 transcriptionally activates USP14 to drive atherosclerosis by promoting EndMT through NLRC5/Smad2/3 axis - PMC

Journal

Molecular medicine (Cambridge, Mass.)

Published

2024

Application

5.7

Species

Homo sapiens,Mus musculus

PMID

38424494

Harmine ameliorates CCl4-induced acute liver injury through suppression of autophagy and inflammation

Journal

International immunopharmacology

Published

2024

Application

5.6

Species

Mus musculus

PMID

38306830

GAPDH Is a Novel Ferroptosis-Related Marker and Correlates with Immune Microenvironment in Lung Adenocarcinoma - PMC

Journal

Metabolites

Published

2023

Application

IF:

5.58

Species

Homo sapiens

PMID

36837761

Apoptosis induction in human prostate cancer cells related to the fatty acid metabolism by wogonin-mediated regulation of the AKT-SREBP1-FASN signaling network

Journal

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Published

2022

Application

5.57

Species

Homo sapiens

PMID

36208653

Lethal activity of BRD4 PROTAC degrader QCA570 against bladder cancer cells - PMC

Journal

Frontiers in chemistry

Published

2023

Application

5.54

Species

Homo sapiens

PMID

36733715

Hyperacetylated microtubules assist porcine deltacoronavirus nsp8 to degrade MDA5 via SQSTM1/p62-dependent selective autophagy - PMC

Journal

Journal of virology

Published

2024

Application

5.4

Species

Homo sapiens

PMID

38353538

The Ca2+-dependent phosphatase calcineurin dephosphorylates TBK1 to suppress antiviral innate immunity

Journal

Journal of virology

Published

2024

Application

IF, WB

5.4

Species

Homo sapiens

PMID

38563732

E. globulus leaf EO exhibits anti-inflammatory effects by regulating GSDMD-mediated pyroptosis, thereby alleviating neurological impairment and neuroinflammation

Journal

Journal of ethnopharmacology

Published

2023

Application

5.4

Species

Mus musculus

PMID

38380569

Effective substances and molecular mechanisms guided by network pharmacology: An example study of Scrophulariae Radix treatment of hyperthyroidism and thyroid

Journal

Journal of ethnopharmacology

Published

2024

Application

5.4

Species

Mus musculus

PMID

38423410

Shen Yuan extract exerts a hypnotic effect via the tryptophan/5-hydroxytryptamine/melatonin pathway in mice

Journal

Journal of ethnopharmacology

Published

2024

Application

5.4

Species

Mus musculus

PMID

38428654

Alleviation of mechanical allodynia by 14,15-EET in a central post-stroke pain model: possible role of allopregnanolone and δGABAAR.

Journal

The journal of pain

Published

2018

Application

5.383

Species

Rattus norvegicus

PMID

30500366

In vitro and in vivo relaxation and anti-inflammation of natural flavonoids from Elaeagnus pungens leaf via L-type calcium channel and targeting MAPK signal pathway

Journal

J Ethnopharmacol

Published

2021

Application

5.195

Species

Mus musculus

PMID

33831464

Supplementation of pyrroloquinoline quinone with atorvastatin augments mitochondrial biogenesis and attenuates low grade inflammation in obese rats

Journal

Eur J Pharmacol

Published

2020

Application

IF:

5.195

Species

Mus musculus

PMID

32535101

A Herbal Compound Alleviates Liver Fibrosis Via Inhibiting Nlrp3 Inflammasome Activation in Macrophages

Journal

Journal of ethnopharmacology

Published

2023

Application

WB, qRT-PCR

5.19

Species

Homo sapiens, Mus musculus

PMID

37544346

Chinese medicine formula 'Baipuhuang Keli'inhibits triple-negative breast cancer by hindering DNA damage repair via MAPK/ERK pathway

Journal

Journal of ethnopharmacology

Published

2022

Application

5.19

Species

Mus musculus

PMID

36572327

Heme oxygenase 1 linked to inactivation of subchondral osteoclasts in osteoarthritis - PMC

Journal

Journal of Zhejiang University. Science. B

Published

2024

Application

5.1

Species

Mus musculus

PMID

38910496

Paeoniflorin attenuates particulate matter-induced acute lung injury by inhibiting oxidative stress and NLRP3 inflammasome-mediated pyroptosis through activation of

Journal

Chemico-biological interactions

Published

2024

Application

5.1

Species

Mus musculus

PMID

38705442

Artesunate Induces Ferroptosis in Hepatic Stellate Cells and Alleviates Liver Fibrosis via the ROCK1/ATF3 Axis

Journal

Journal of clinical and translational hepatology

Published

2023

Application

5.06

Species

Mus musculus

PMID

38250467

Oral administration of ellagic acid mitigates perioperative neurocognitive disorders, hippocampal oxidative stress, and neuroinflammation in aged mice by restoring IGF-1 signaling - PMC

Journal

Scientific reports

Published

2024

Application

4.99

Species

Homo sapiens

PMID

38291199

Harmine suppresses homologous recombination repair and inhibits proliferation of hepatoma cells .

Journal

Cancer Biology & Therapy

Published

2015

Application

4.875

Species

Homo sapiens

PMID

26382920

MicroRNA-155 suppressed cholesterol-induced matrix degradation, pyroptosis and apoptosis by targeting ROR in nucleus pulposus cells

Journal

Cellular signalling

Published

2023

Application

4.85

Species

Mus musculus

PMID

37062437

CHD4 mediates SOX2 transcription through TRPS1 in luminal breast cancer

Journal

Cellular signalling

Published

2022

Application

4.85

Species

Homo sapiens

PMID

36075559

circFBXW7 attenuates malignant progression in lung adenocarcinoma by sponging miR-942-5p

Journal

Transl Lung Cancer Res

Published

2021

Application

4.726

Species

Homo sapiens

PMID

33889522

The role of necroptosis and apoptosis through the oxidative stress pathway in the liver of selenium-deficient swine

Journal

Metallomics : Integrated Biometal Science

Published

2020

Application

4.636

Species

Sus scrofa

PMID

32176230

Melatonin alleviates lead-induced intestinal epithelial cell pyroptosis in the common carps (Cyprinus carpio) via miR-17-5p/TXNIP axis

Journal

Fish & shellfish immunology

Published

2022

Application

4.62

Species

Other

PMID

36202203

Chronic Polystyrene Microplastic Exposure Reduces Testosterone Levels in Mice through Mitochondrial Oxidative Stress and BAX/BCL2-Mediated Apoptosis - PMC

Journal

Toxics

Published

2024

Application

IF:

4.6

Species

Mus musculus

PMID

39195663

MiR-196a-5p hinders vascular smooth muscle cell proliferation and vascular remodeling via repressing BACH1 expression - PMC

Journal

Scientific reports

Published

2024

Application

4.6

Species

Homo sapiens

PMID

39043832

Fraxetin inhibits interleukin-1β-induced apoptosis, inflammation, and matrix degradation in chondrocytes and protects rat cartilage in vivo

Journal

Saudi Pharm J

Published

2020

Application

IF:

4.562

Species

Rattus norvegicus

PMID

33424243

Study of FOXO1-interacting proteins using TurboID-based proximity labeling technology - PMC

Journal

BMC genomics

Published

2023

Application

IF:

4.54

Species

Homo sapiens

PMID

36964488

Collective influence of substrate chemistry with physiological fluid shear stress on human umbilical vein endothelial cells

Journal

Cell Biol Int

Published

2021

Application

IF:

4.473

Species

Homo sapiens

PMID

34009727

Knockdown of fat mass and obesity alleviates the ferroptosis in Parkinson's disease through m6ANRF2dependent manner

Journal

Cell biology international

Published

2024

Application

4.47

Species

Homo sapiens

PMID

38180302

A Comprehensive Analysis of the Prognostic, Immunological and Diagnostic Role of CCNF in Pan-cancer - PMC

Journal

Journal of Cancer

Published

2023

Application

4.47

Species

Homo sapiens

PMID

37670965

Resveratrol Attenuated Manganese-Induced Learning and Memory Impairments in Mice Through PGC-1Alpha-Mediated Autophagy and Microglial M1/M2 …

Journal

Neurochemical research

Published

2022

Application

4.41

Species

Mus musculus

PMID

35871432

Zika virus dysregulates the expression of astrocytic genes involved in neurodevelopment

Journal

PLoS Negl Trop Dis

Published

2021

Application

4.41

Species

Mus musculus

PMID

33891593

Genomic analysis and functional characterization of immune genes from the RIG-I- and MAVS-mediated antiviral signaling pathway in lamprey

Journal

Genomics

Published

2021

Application

IF:

4.4

Species

Lampetra japonica

PMID

33887365

Osteoblasts of calvaria induce higher numbers of osteoclasts than osteoblasts from long bone

Journal

Bone

Published

2015

Application

IF:

4.398

Species

Homo sapiens

PMID

26921824

Protective Effect of Rutin on Spinal Motor Neuron in Rats Exposed to Acrylamide and the Underlying Mechanism

Journal

Neurotoxicology

Published

2023

Application

IF:

4.39

Species

Rattus norvegicus

PMID

36657526

Cytoplasmic domain and enzymatic activity of ACE2 are not required for PI4KB dependent endocytosis entry of SARS-CoV-2 into host cells

Journal

Virologica Sinica

Published

2022

Application

4.32

Species

Homo sapiens

PMID

35272059

Chlorogenic Acid Inhibits Human Glioma U373 Cell Progression via Regulating the SRC/MAPKs Signal Pathway: Based on Network Pharmacology Analysis

Journal

Drug Des Devel Ther

Published

2021

Application

4.319

Species

Homo sapiens

PMID

33833498

Role of FSH and FSH receptor on HUVECs migration

Journal

Gene Ther

Published

2020

Application

IF:

4.184

Species

Homo sapiens

PMID

32994568

Effects of manganese on microglia M1/M2 polarization and SIRT1-mediated transcription of STAT3-dependent genes in mouse

Journal

Environ Toxicol

Published

2021

Application

IF:

4.109

Species

Mus musculus

PMID

34018660

Specificity and application of SOX2 antibody

Journal

Poult Sci

Published

2020

Application

IF:

4.014

Species

Gallus gallus

PMID

32359573

Inhibition of cysteine-serine-rich nuclear protein 1 ameliorates ischemia-reperfusion injury during liver transplantation in an MAPK-dependent manner - PMC

Journal

Molecular biomedicine

Published

2024

Application

Species

Mus musculus

PMID

38902590

Bisbenzylisoquinoline alkaloids from Plumula Nelumbinis inhibit vascular smooth muscle cells migration and proliferation by regulating the ORAI2/Akt pathway

Journal

Phytochemistry

Published

2023

Application

IF:

Species

Mus musculus

PMID

37119920

Cyanidin attenuates IL-17A cytokine signaling mediated monocyte migration and differentiation into mature osteoclasts in rheumatoid arthritis

Journal

Cytokine

Published

2021

Application

IF:

3.926

Species

Rattus norvegicus

PMID

33810944

Proteomic and phosphoproteomic analyses of Jurkat T-cell treated with 2 3 cGAMP reveals various signaling axes impacted by cyclic dinucleotides

Journal

Journal of proteomics

Published

2023

Application

3.85

Species

Homo sapiens, Mus musculus

PMID

36889538

Molecular Characterization and Functional Analysis of a Putative Octopamine/Tyramine Receptor during the Developmental Stages of the Pacific Oyster, Crassostrea gigas

Journal

Plos One

Published

2017

Application

IF:

3.752

Species

Crassostrea gigas

PMID

27992549

Tributyrin alleviates gut microbiota dysbiosis to repair intestinal damage in antibiotic-treated mice - PMC

Journal

PloS one

Published

2023

Application

IF:

3.75

Species

Mus musculus

PMID

37523400

Chemotherapy-induced peripheral neuropathy is promoted by enhanced spinal insulin-like growth factor-1 levels via astrocyte-dependent mechanisms

Journal

Brain Res Bull

Published

2021

Application

IF:

3.715

Species

Mus musculus

PMID

34333050

Icariin Ameliorates Behavioral Deficits and Neuropathology in a Mouse Model of Multiple Sclerosis

Journal

Brain research

Published

2023

Application

IF:

3.61

Species

Mus musculus

PMID

36731819

Sirt1 Regulates Oxidative Stress in Oxygen-Glucose Deprived Hippocampal Neurons

Journal

Front Pediatr

Published

2020

Application

IF:

3.569

Species

Rattus norvegicus

PMID

32923413

GPM6B Inhibit PCa Proliferation by Blocking Prostate Cancer Cell Serotonin Absorptive Capacity

Journal

Disease Markers

Published

2020

Application

IF:

3.464

Species

Homo sapiens

PMID

33294057

Kaempferol inhibits multiple pathways involved in the secretion of inflammatory mediators from LPS‑induced rat intestinal microvascular endothelial cells

Journal

Molecular medicine reports

Published

2018

Application

3.423

Species

Rattus norvegicus

PMID

30569099

Ginsenoside Rh2 inhibits human A172 glioma cell proliferation and induces cell cycle arrest status via modulating Akt signaling pathway

Journal

Molecular medicine reports

Published

2018

Application

3.423

Species

Homo sapiens

PMID

29207171

Cadmium triggers oxidative stress and mitochondrial injury mediated apoptosis in human extravillous trophoblast HTR-8/SVneo cells

Journal

Reprod Toxicol

Published

2021

Application

IF:

3.421

Species

Homo sapiens

PMID

33588013

GL-V9 synergizes with oxaliplatin of colorectal cancer via Wee1 degradation mediated by HSP90 inhibition

Journal

The Journal of pharmacy and pharmacology

Published

2024

Application

3.3

Species

Homo sapiens

PMID

38767973

Norepinephrine-Activated p38 MAPK Pathway Mediates Stress-Induced Cytotoxic Edema of Basolateral Amygdala Astrocytes - PMC

Journal

Brain sciences

Published

2024

Application

IF:

3.3

Species

Rattus norvegicus

PMID

38391735

HMGA1 and FOXM1 Cooperate to Promote G2/M Cell Cycle Progression in Cancer Cells - PMC

Journal

Life (Basel, Switzerland)

Published

2023

Application

3.25

Species

Homo sapiens

PMID

37240870

Microcyst fluid promotes the migration and invasion of fibroblasts in the adventitial layer of alveolar echinococcosis

Journal

Acta Trop

Published

2021

Application

IF:

3.222

Species

Mus musculus

PMID

34389327

A selective NLRP3 inflammasome inhibitor attenuates behavioral deficits and neuroinflammation in a mouse model of Parkinson's disease

Journal

J Neuroimmunol

Published

2021

Application

IF:

3.221

Species

Mus musculus

PMID

33714750

L-fucose ameliorates the carcinogenic properties of Fusobacterium nucleatum in colorectal cancer

Journal

Oncol Lett

Published

2021

Application

IF:

3.111

Species

Homo sapiens

PMID

33552262

Xiaoliu Pingyi Pecipe Inhibits Lung Pre-Metastatic Niche Formation and Prevents Myeloid-Derived Suppressor Cells Recruitment - PMC

Journal

Integrative cancer therapies

Published

2023

Application

3.07

Species

Mus musculus

PMID

37431869

The modulatory properties of Astragalus membranaceus treatment on endometrial cancer: an integrated pharmacological method

Journal

PeerJ

Published

2021

Application

IF:

3.061

Species

Homo sapiens

PMID

34513331

Bioinformatics analysis of laryngeal squamous cell carcinoma: seeking key candidate genes and pathways

Journal

PeerJ

Published

2021

Application

IF:

3.061

Species

Homo sapiens

PMID

33954053

Stability of Dengue 2 Nonstructural Glycoprotein 1 (NS1) Is Affected by the Nature of Basic Residue at Position NS1-324 - PMC

Journal

Current issues in molecular biology

Published

2023

Application

2.97

Species

Homo sapiens

PMID

36826051

MCC950 improves lipopolysaccharide-induced systemic inflammation in mice by relieving pyroptosis in blood neutrophils - PMC

Journal

Experimental and therapeutic medicine

Published

2023

Application

2.75

Species

Mus musculus

PMID

37602308

IL-37 suppresses macrophage ferroptosis to attenuate diabetic atherosclerosis via the NRF2 pathway - PMC

Journal

Experimental and therapeutic medicine

Published

2023

Application

2.75

Species

Mus musculus

PMID

37206550

Respiratory syncytial virus infection up-regulates TLR7 expression by inducing oxidative stress via the Nrf2/ARE pathway in A549 cells

Journal

Archives of Virology

Published

2018

Application

2.685

Species

Homo sapiens

PMID

29392496

Oridonin Attenuates Lipopolysaccharide-Induced ROS Accumulation and Inflammation in HK-2 Cells

Journal

Evidence-based Complementary and Alternative Medicine : Ecam

Published

2020

Application

WB, IF

2.65

Species

Homo sapiens, Mus musculus

PMID

32184902

Mitochondrial dysfunction in follicles is associated with broodiness in Zhedong white goose

Journal

Animal reproduction science

Published

2022

Application

2.22

Species

Anser cygnoides

PMID

35820352

A Key regulatory protein QRICH2 governing sperm function with profound antioxidant properties, enhancing sperm viability

Journal

Reproductive biology

Published

2024

Application

2.1

Species

Mus musculus

PMID

38772286

GDNF enhances the anti-inflammatory effect of human adipose-derived mesenchymal stem cell-based therapy in renal interstitial fibrosis

Journal

Stem Cell Research

Published

2019

Application

1.587

Species

Mus musculus

PMID

31706095

The effects of celecoxib on the proliferation and ultrastructural changes of MDA-MB-231 breast cancer cells

Journal

Ultrastructural pathology

Published

2018

Application

1.385

Species

Homo sapiens

PMID

29668331

AEBP1 exacerbates myocardial ischemia-reperfusion injury via inhibition of IB

Journal

Folia morphologica

Published

2023

Application

1.19

Species

Rattus norvegicus

PMID

37957937

TRPA1 aggravates osteoclastogenesis and osteoporosis through activating endoplasmic reticulum stress mediated by SRXN1 - PMC

Journal

Cell death & disease

Published

2024

Application

Species

Mus musculus

PMID

39191723

USP7 inhibits the progression of nasopharyngeal carcinoma via promoting SPLUNC1-mediated M1 macrophage polarization through TRIM24 - PMC

Journal

Cell death & disease

Published

2023

Application

Species

Homo sapiens, Mus musculus

PMID

38129408

REPIN1 regulates iron metabolism and osteoblast apoptosis in osteoporosis - PMC

Journal

Cell death & disease

Published

2023

Application

Species

Mus musculus

PMID

37749079

背景信息

This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility, structure, integrity, and intercellular signaling. The encoded protein is a major constituent of the contractile apparatus and one of the two nonmuscle cytoskeletal actins that are ubiquitously expressed. Mutations in this gene cause Baraitser-Winter syndrome 1, which is characterized by intellectual disability with a distinctive facial appearance in human patients. Numerous pseudogenes of this gene have been identified throughout the human genome.

RRID

AB_2768236

基因ID

Swiss Prot

P60709

别名

BRWS1; PS1TP5BP1; β-Actin

抗原信息

免疫原

Recombinant fusion protein containing a sequence corresponding to amino acids 1-375 of human β-Actin (NP_001092.1).

序列

MDDDIAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHETTFNSIMKCDVDIRKDLYANTVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF

进行序列比对

研究领域

关联靶点

以ACTB为关键词搜索文献记录，得到上述基因与ACTB的研究紧密相关，排序顺序根据研究相关程度由高到低决定。（所显示数字代表两者共同出现的已发表文献数量）

◀1/▶

关联领域

以ACTB为关键词搜索文献记录，得到上述相关热词信息，可反映出ACTB的研究趋势与热点。（关联领域与基因名称的距离代表其研究热度）

* 该数据来源于赛特新思(citexs.com)
来自于发表文献，仅供参考所用，ABclonal不承担任何责任。

暂无以ACTB为关键词搜索的文献记录。

该服务由赛特新思提供，上述关联分析来自已发表文献，仅供参考所用，ABclonal不承担任何责任。

FAQ

折叠内容

ABclonal公司的抗体，可以回收利用几次？

首先，一般抗体不推荐客户回收利用，抗体使用之后缓冲体系已经发生改变，不同客户在回收抗体的保存条件上也会有差异，所以抗体回收使用效果无法保证。另外，ABclonal公司也做过一批抗体回收验证测试，测试结果显示不同抗体可回收次数不同，一般效价越高的抗体，可重复使用的次数越多，客户可根据实验情况来确定。
注：我们将孵育完毕后剩余的抗体回收到离心管中置于4℃保存，效价高的抗体可至少保存1周，至少重复利用3次。

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ABclonal作为国产抗体品牌的优势？

武汉爱博泰克生物（ABclonal）科技有限公司是国产品牌，她成立于2011年，公司依托ABclonal美国波士顿抗体与蛋白研发中心、中国光谷生物城(武汉)抗体生产基地以及上海张江分子酶研发中心，凝聚了十余位来自哈佛大学、麻省理工、复旦大学、上海交大、中科院生化细胞所和武汉大学的全球知名分子和免疫学方面博士，组成我们的科学家团队，通过聚焦抗体与酶核心技术，致力于打破国际技术的垄断，将公司打造成为科研工具和诊断原料的国内领导品牌，乃至弯道超越国际巨头。我们拥有包括兔多克隆抗体、小鼠单克隆抗体、兔单克隆抗体的生产研发平台，同时也有包括WB,IHC,IF,IP,CHIP在内的检测平台，我们对每一支自产的抗体进行了严格的检测。当然，我们部分直销地区也可以帮客户代购进口品牌的产品。同时也有抗体定制服务。ABclonal抗体优势：1，严自检，保质量；2产品多，指标全；3，价格低，货期短。注：ABclonal抗体价格体系详情见附件

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ABclonal抗体成分？

ABclonal抗体成分在平时工作当中，常会有客户咨询我们的抗体用的什么buffer进行保存，一般来说，我们的buffer的成分是：PBS含0.03%的proclin300、0.05%牛血清白蛋白、50%甘油；也有一些是PBS含0.03%的proclin300，50%甘油。防腐剂 Proclin 300活性成分主要是2-甲基-4-异噻唑啉-3-酮（MCI）和5-氯-2-甲基-4-异噻唑啉-3-酮（CMCI）。ProClin生物灭活剂能够迅速穿透细胞膜，抑制对细胞呼吸至关重要的特定酶，因此一接触微生物有机体就会立即抑制细胞活性。ProClin的多个特定毒性位点可以防止微生物产生高水平的耐药性。

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