Recognition of cyclic dinucleotides and folates by human SLC19A1
De novo pyrimidine biosynthetic complexes support cancer cell proliferation and ferroptosis defence
Journal
Nature cell biology
Evolutionary metabolic landscape from preneoplasia to invasive lung adenocarcinoma
The KLF7/PFKL/ACADL axis modulates cardiac metabolic remodelling during cardiac hypertrophy in male mice - PMC
Journal
Nature communications
TRADES: Targeted RNA Demethylation by SunTag System
Transgelin Promotes Glioblastoma Stem Cell Hypoxic Responses and Maintenance Through p53 Acetylation
Journal
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Species
Capra hircus,Homo sapiens
Deciphering the Molecular Characteristics of Human Idiopathic Nonobstructive Azoospermia from the Perspective of Germ Cells
Journal
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Menin Deficiency Induces AutismLike Behaviors by Regulating Foxg1 Transcription and Participates in Foxg1Related Encephalopathy
Journal
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
PLD1 promotes Spindle Assembly and migration through regulating autophagy in mouse oocyte meiosis
Mitochondrial-targeted brequinar liposome boosted mitochondrial-related ferroptosis for promoting checkpoint blockade immunotherapy in bladder cancer
Journal
Journal of controlled release : official journal of the Controlled Release Society
Low Surface Accessible Area NanoCoral TiO 2 for the Reduction of Foreign Body Reaction During Implantation
Journal
Advanced healthcare materials
CCDC176 stabilizes microtubule doublets 1 and 9 to ensure proper sperm movement
Journal
Current biology : CB
The NAD-dependent deacetylase SIRT2 regulates T cell differentiation involved in tumor immune response
Autophagy resists EMT process to maintain retinal pigment epithelium homeostasis.
Journal
International journal of biological sciences
A Novel SPAST Mutation Results in Spastin Accumulation and Defects in Microtubule Dynamics
RNF8 up-regulates AR/ARV7 action to contribute to advanced prostate cancer progression
Journal
Cell death & disease
Artemisia scoparia promotes adipogenesis in the absence of adipogenic effectors
Journal
Obesity (Silver Spring)
Species
Artemisia scoparia
Tenascin-C can Serve as an Indicator for the Immunosuppressive Microenvironment of Diffuse Low-Grade Gliomas
Journal
Frontiers in immunology
SIRT1 activation by 2,3,5,6-tetramethylpyrazine alleviates neuroinflammation via inhibiting M1 microglia polarization - PMC
Journal
Frontiers in immunology
β-Trcp and CK1δ-mediated degradation of LZTS2 activates PI3K/AKT signaling to drive tumorigenesis and metastasis in hepatocellular carcinoma
Cyclohexylalanine-Containing -Helical Amphipathic Peptide Targets Cardiolipin, Rescuing Mitochondrial Dysfunction in Kidney Injury
Journal
Journal of medicinal chemistry
Degradation of Cyclin-Dependent Kinase 9/Cyclin T1 by Optimized Microtubule-Associated Protein 1 Light Chain 3 Beta-Recruiting Coumarin Analogs
Journal
Journal of medicinal chemistry
Senataxin deficiency disrupts proteostasis through nucleolar ncRNA-driven protein aggregation
Journal
The Journal of cell biology
CHK2 Promotes Metabolic Stress-Induced Autophagy through ULK1 Phosphorylation - PMC
Journal
Antioxidants (Basel, Switzerland)
REC8 suppresses tumor angiogenesis by inhibition of NF-κB-mediated vascular endothelial growth factor expression in gastric cancer cells
MITA oligomerization upon viral infection is dependent on its N-glycosylation mediated by DDOST - PMC
Shen Qi Wan ameliorates nephritis in chronic kidney disease via AQP1 and DEFB1 regulation
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Cardioprotective Effects of Aconite in Isoproterenol-Induced Myocardial Infarction in Rats
Journal
Oxidative medicine and cellular longevity
Cardioprotective Effects of Aconite in Isoproterenol-Induced Myocardial Infarction in Rats
Journal
Oxidative medicine and cellular longevity
Mitochondrial homeostasis regulates definitive endoderm differentiation of human pluripotent stem cells
Journal
Cell death discovery
Oxysterol-binding protein-like 2 contributes to the developmental progression of preadipocytes by binding to β-catenin
Design, synthesis, and biological evaluation of novel 4, 4-bipyridine derivatives acting as CDK9-Cyclin T1 protein-protein interaction inhibitors against triple
Journal
European journal of medicinal chemistry
Species
Homo sapiens, Mus musculus,
Ccdc38 is required for sperm flagellum biogenesis and male fertility in mice
Journal
Development (Cambridge, England)
Magnolol and Temozolomide exhibit a synergistic anti-glioma activity through MGMT inhibition
Journal
Biochimica et biophysica acta. Molecular basis of disease
Species
Homo sapiens,Rattus norvegicus
Oleic Acid Exhibits Anti-Proliferative and Anti-Invasive Activities via the PTEN/AKT/mTOR Pathway in Endometrial Cancer - PMC
Inhibitory Effect of Delphinidin on Oxidative Stress Induced by H2O2 in HepG2 Cells
Journal
Oxidative Medicine and Cellular Longevity
SLC35B2 Acts in a Dual Role in the Host Sulfation Required for EV71 Infection
Journal
Journal of virology
Mitotic catastrophe and p53-dependent senescence induction in T-cell malignancies exposed to nonlethal dosage of GL-V9
Journal
rchives of Toxicology
Hypoxia-induced HMGB1 promotes glioma stem cells self-renewal and tumorigenicity via RAGE - PMC
A missense variant in the nuclear localization signal of DKC1 causes Hoyeraal-Hreidarsson syndrome - PMC
Journal
NPJ genomic medicine
Porcine Sapelovirus 3Cpro Inhibits the Production of Type I Interferon - PMC
Journal
Frontiers in cellular and infection microbiology
CHCHD2 Thr61Ile mutation impairs F1F0-ATPase assembly in in vitro and in vivo models of Parkinson's disease
Journal
Neural regeneration research
Effects of unburned tobacco smoke on inflammatory and oxidative mediators in the rat prefrontal cortex - PMC
Journal
Frontiers in pharmacology
Improving the anti-tumor effect of EGCG in colorectal cancer cells by blocking EGCG-induced YAP activation - PMC
Journal
American journal of cancer research
Mechanism of Tao Hong Decoction in the treatment of atherosclerosis based on network pharmacology and experimental validation - PMC
Journal
Frontiers in cardiovascular medicine
NSs Filament Formation Is Important but Not Sufficient for RVFV Virulence In Vivo.
Prognostic Value and Biological Function of Galectins in Malignant Glioma - PMC
Journal
Frontiers in oncology
Deletion of Insulin-like growth factor II mRNA-binding protein 3 participates in the pathogenesis of recurrent spontaneous abortion by inhibiting IL-10 secretion and …
Journal
International immunopharmacology
Phosphorylation of MITF by AKT affects its downstream targets and causes TP53-dependent cell senescence
Journal
The international journal of biochemistry & cell biology
A20 prevents obesity-induced development of cardiac dysfunction
Journal
journal of molecular medicine-jmm
Acetylated tau exacerbates apoptosis by disturbing mitochondrial dynamics in HEK293 cells
Journal
Journal of neurochemistry
The temporal association of CapZ with early endosomes regulates endosomal trafficking and viral entry into host cells - PMC
HDAC6‐mediated α‐tubulin deacetylation suppresses autophagy and enhances motility of podocytes in diabetic nephropathy
CXCL2 attenuates osteoblast differentiation by inhibiting the ERK1/2 signaling pathway
Journal
Journal of cell science
Equal distribution of lipid droplets in daughter cells is regulated by microtubules
Journal
Cell cycle (Georgetown, Tex.)
BMP4 participates in the pathogenesis of PCOS by regulating glucose metabolism and autophagy in granulosa cells under hyperandrogenic environment
Journal
The Journal of steroid biochemistry and molecular biology
Nrf2?ARE Signaling Acts as Master Pathway for the Cellular Antioxidant Activity of Fisetin.
Ethanol Extract of Rosa laevigata Michx. Fruit Inhibits Inflammatory Responses through NF-B/MAPK Signaling Pathways via AMPK Activation in RAW 264.7 Macrophages - PMC
Journal
Molecules (Basel, Switzerland)
Exercised accelerated the production of muscle-derived kynurenic acid in skeletal muscle and alleviated the postmenopausal osteoporosis through the Gpr35 …
Journal
Journal of orthopaedic translation
Pancancer analysis of oncogenic role of insulinlike growth factorbinding proteins and validation in ovarian cancer
march2 negatively regulates antiviral immune response by targeting tbk1 in grass carp (Ctenopharyngodon idella)
Journal
Fish & shellfish immunology
Functional characterization of a putative lipopolysaccharide-induced TNF-alpha factor (LITAF) from blood clam Tegillarca granosa in innate immunity
Journal
Fish & Shellfish Immunology
Species
Tegillarca granosa
Prodigiosin Promotes Nrf2 Activation to Inhibit Oxidative Stress Induced by Microcystin-LR in HepG2 Cells.
Spermatogenic cell-specific type 1 hexokinase (HK1S) is essential for capacitation-associated increase in tyrosine phosphorylation and male fertility in mice - PMC
Creatine ameliorates high-fat diet-induced obesity by regulation of lipolysis and lipophagy in brown adipose tissue and liver
Downregulated miR-585-3p promotes cell growth and proliferation in colon cancer by upregulating PSME3.
Journal
OncoTargets and therapy
The effects of dual IQOS and cigarette smoke exposure on airway epithelial cells: implications for lung health and respiratory disease pathogenesis - PMC
TBC1D21 is an essential factor for sperm mitochondrial sheath assembly and male fertility
Journal
Biology of reproduction
Transcripts 202 and 205 of IL-6 confer resistance to Vemurafenib by reactivating the MAPK pathway in BRAF(V600E) mutant melanoma cells
Journal
Experimental Cell Research
Isoimperatorin Inhibits Angiogenesis by Suppressing VEGFR2 Signaling Pathway
Journal
Cardiovascular drugs and therapy
Inhibition of CXCR4 ameliorates hypoxia-induced pulmonary arterial hypertension in rats
Fisetin inhibits inflammation and induces autophagy by mediating PI3K/AKT/mTOR signaling in LPS-induced RAW264.7 cells
Network pharmacology, molecular docking, combined with experimental verification to explore the role and mechanism of shizhifang decoction in the treatment of hyperuricemia - PMC
Analysis of DNA topology of EBV minichromosomes in HEK 293 cells
YAP confers resistance to vandetanib in medullary thyroid cancer
Journal
Biochemistry and cell biology = Biochimie et biologie cellulaire
Molecular cloning and characterization of a cDNA encoding extracellular signal-regulated kinase (ERK) from the blood clam Tegillarca granosa
Journal
Developmental and Comparative Immunology
Species
Tegillarca granosa
Design, synthesis, and biological evaluation of histone deacetylase inhibitors possessing glutathione peroxidase-like and antioxidant activities against Alzheimer's disease.
Journal
Bioorganic & medicinal chemistry
Testis-expressed protein 33 is not essential for spermiogenesis and fertility in mice
A loss-of-function variant in ZCWPW1 causes human male infertility with sperm head defect and high DNA fragmentation - PMC
Journal
Reproductive health
CD147 Aggravated Inflammatory Bowel Disease by Triggering NF-κB-Mediated Pyroptosis
CD147 Expression Is Associated with Tumor Proliferation in Bladder Cancer via GSDMD
Journal
Biomed Research International
TPI1 promotes MAPK/ERKinduced EMT, cell migration and invasion in lung adenocarcinoma
CRISPR/Cas9-mediated deletion of the Wiskott-Aldrich syndrome locus causes actin cytoskeleton disorganization in murine erythroleukemia cells.
Dual role of NR4A1 in porcine ovarian granulosa cell differentiation and granulosa-lutein cell regression in vitro
CXCR7 promotes pulmonary vascular remodeling via targeting p38/MMP2 pathway in pulmonary arterial hypertension - PMC
Journal
Journal of thoracic disease
A Key regulatory protein QRICH2 governing sperm function with profound antioxidant properties, enhancing sperm viability
Journal
Reproductive biology
The phosphorylation-deubiquitination positive feedback loop of the CHK2-USP7 axis stabilizes p53 under oxidative stress
The phosphorylation-deubiquitination positive feedback loop of the CHK2-USP7 axis stabilizes p53 under oxidative stress
U3 snoRNA inter-regulates with DDX21 in the perichromosomal region to control mitosis - PMC
Journal
Cell death & disease
AR antagonists develop drug resistance through TOMM20 autophagic degradation-promoted transformation to neuroendocrine prostate cancer - PMC
Journal
Journal of experimental & clinical cancer research : CR
Inhibition of SIRT2 promotes APP acetylation and ameliorates cognitive impairment in APP/PS1 transgenic mice