Hyperglycemia-Driven Inhibition of AMP-Activated Protein Kinase α2 Induces Diabetic Cardiomyopathy by Promoting Mitochondria-Associated Endoplasmic Reticulum Membranes In Vivo.
Exosomes secreted from cardiomyocytes suppress the sensitivity of tumor ferroptosis in ischemic heart failure - PMC
Journal
Signal transduction and targeted therapy
Upf3a but not Upf1 mediates the genetic compensation response induced by leg1 deleterious mutations in an H3K4me3-independent manner - PMC
Multiomic analysis of cervical squamous cell carcinoma identifies cellular ecosystems with biological and clinical relevance
The piRNA CHAPIR regulates cardiac hypertrophy by controlling METTL3-dependent N 6-methyladenosine methylation of Parp10 mRNA
Zfp217 mediates m6A mRNA methylation to orchestrate transcriptional and post-transcriptional regulation to promote adipogenic differentiation.
Journal
Nucleic acids research
WEE1 inhibition induces anti-tumor immunity by activating ERV and the dsRNA pathway
A conserved oomycete effector RxLR23 triggers plant defense responses by targeting ERD15La to release NbNAC68 - PMC
Journal
Nature communications
Species
Arabidopsis thaliana
The Compromised Fanconi Anemia Pathway in Prelamin AExpressing Cells Contributes to Replication StressInduced Genomic Instability
Journal
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
RNA m6 A methylation regulates sorafenib resistance in liver cancer through FOXO3-mediated autophagy
ALKBH5 facilitates hypoxia-induced paraspeckle assembly and IL8 secretion to generate an immunosuppressive tumor microenvironment
TRPM2 as a conserved gatekeeper determines the vulnerability of DA neurons by mediating ROS sensing and calcium dyshomeostasis
Journal
Progress in neurobiology
HOS15 and HDA9 negatively regulate immunity through histone deacetylation of intracellular immune receptor NLR genes in Arabidopsis
Journal
The New Phytologist
Species
Arabidopsis thaliana
PA1 participates in the maintenance of blood-testis barrier integrity via cooperation with JUN in the Sertoli cells of mice
Species
Homo sapiens, Mus musculus
Cold-Inducible Klf9 Regulates Thermogenesis of Brown and Beige Fat
Global phosphoproteomic analysis identified key kinases regulating male meiosis in mouse
Journal
Cellular and molecular life sciences : CMLS
PARP inhibition leads to synthetic lethality with key splicing-factor mutations in myelodysplastic syndromes
Journal
British journal of cancer
Gαq-PKD/PKCμ signal regulating the nuclear export of HDAC5 to induce the IκB expression and limit the NF-κB-mediated inflammatory response essential for early pregnancy - PMC
RIPK3-MLKL necroptotic signalling amplifies STING pathway and exacerbates lethal sepsis - PMC
Journal
Clinical and translational medicine
CRM197-conjugated multi antigen dominant epitope for effective human cytomegalovirus vaccine development
Journal
International journal of biological macromolecules
Species
Homo sapiens, Mus musculus
Cornus officinalis Sieb. attenuates A25-35-induced mitochondrial damage and neuroinflammation in mice by modulating the ERK pathway
Journal
Phytomedicine : international journal of phytotherapy and phytopharmacology
METTL14 Regulates Osteogenesis of Bone Marrow Mesenchymal Stem Cells via Inducing Autophagy Through m6A/IGF2BPs/Beclin-1 Signal Axis
Journal
Stem cells translational medicine
Species
Homo sapiens,Mus musculus
Slc2a6 regulates myoblast differentiation by targeting LDHB - PMC
Journal
Cell communication and signaling : CCS
Inhibition of mitochondrial fusion via SIRT1/PDK2/PARL axis breaks mitochondrial metabolic plasticity and sensitizes cancer cells to glucose restriction
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
P-coumaric acid ameliorates A2535-induced brain damage in mice by modulating gut microbiota and serum metabolites
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
LW-213, a newly synthesized flavonoid, induces G2/M phase arrest and apoptosis in chronic myeloid leukemia.
Journal
Acta Pharmacologica Sinica
Total flavonoids of Selaginella tamariscina (P.Beauv.) Spring ameliorates doxorubicin-induced cardiotoxicity by modulating mitochondrial dysfunction and endoplasmic reticulum stress via activating MFN2/PERK
Journal
Phytomedicine : international journal of phytotherapy and phytopharmacology
Newcastle Disease Virus Manipulates Mitochondrial MTHFD2-Mediated Nucleotide Metabolism for Virus Replication
Journal
Journal of virology
Species
Mesocricetus auratus
Novel bi-allelic variants in ACTL7A are associated with male infertility and total fertilization failure
Journal
Human reproduction (Oxford, England)
Paclitaxel Overload Supramolecular Oxidative Stress Nanoamplifier with a CDK12 Inhibitor for Enhanced Cancer Therapy
Epithelial Galectin-3 Induced the Mitochondrial Complex Inhibition and Cell Cycle Arrest of CD8+ T Cells in Severe/Critical COVID-19 - PMC
Journal
International journal of molecular sciences
Serotonin Transporter Activity in Mouse Oocytes Is a Positive Indicator of Follicular Growth and Oocyte Maturity - PMC
Journal
International journal of molecular sciences
Epilepsy gene prickle ensures neuropil glial ensheathment through regulating cell adhesion molecules - PMC
Hepatic depletion of nucleolar protein mDEF causes excessive mitochondrial copper accumulation associated with p53 and NRF1 activation - PMC
Mettl14 Attenuates Cardiac Ischemia/Reperfusion Injury by Regulating Wnt1/β-Catenin Signaling Pathway.
Journal
Frontiers in cell and developmental biology
The Recurrent Mutation in PATL2 Inhibits Its Degradation Thus Causing Female Infertility Characterized by Oocyte Maturation Defect Through Regulation of the Mos-MAPK Pathway.
Journal
Front Cell Dev Biol
Vi4-miR-185-5p-Igfbp3 Network Protects the Brain From Neonatal Hypoxic Ischemic Injury via Promoting Neuron Survival and Suppressing the Cell Apoptosis
Journal
Frontiers in Cell and Developmental Biology
Screening and Identification of Lujo Virus Entry Inhibitors From an Food and Drug Administration-Approved Drugs Library
Astragalus polysaccharide protects sepsis model rats after cecum ligation and puncture - PMC
Journal
Frontiers in bioengineering and biotechnology
The classic metal-sensing transcription factor MTF1 promotes myogenesis in response to copper
Journal
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Mesencephalic astrocyte-derived neurotrophic factor alleviates non-alcoholic steatohepatitis induced by Western diet in mice
Journal
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Alpha-2-macroglobulin as a novel diagnostic biomarker for human bladder cancer in urinary extracellular vesicles - PMC
Journal
Frontiers in oncology
NGF-Induced Nav1. 7 Upregulation Contributes to Chronic Post-surgical Pain by Activating SGK1-Dependent Nedd4-2 Phosphorylation
Role of Ciminalum-4-thiazolidinone Hybrids in Molecular NF-B Dependent Pathways - PMC
Journal
International journal of molecular sciences
miR-107 Targets NSG1 to Regulate Hypopharyngeal Squamous Cell Carcinoma Progression through ERK Pathway - PMC
Journal
International journal of molecular sciences
Bi-allelic variants in human TCTE1/DRC5 cause asthenospermia and male infertility
Journal
European journal of human genetics : EJHG
Necrostatin-1 protects C2C12 myotubes from CoCl2-induced hypoxia.
Journal
International Journal of Molecular Medicine
Proteomics-based screening of the target proteins associated with antidepressant-like effect and mechanism of Saikosaponin A
Journal
Journal of Cellular and Molecular Medicine
Notopterol Ameliorates Hyperuricemia-Induced Cardiac Dysfunction in Mice - PMC
Journal
Pharmaceuticals (Basel, Switzerland)
Species
Mus musculus, Rattus norvegicus
Molecular docking, network pharmacology and experimental verification to explore the mechanism of Wulongzhiyangwan in the treatment of pruritus - PMC
Journal
Scientific reports
Morusin Enhances Temozolomide Efficiency in GBM by Inducing Cytoplasmic Vacuolization and Endoplasmic Reticulum Stress - PMC
Journal
Journal of clinical medicine
Hypoxia-inducible PRMT2 addiction in glioblastomas
Journal
Cellular signalling
The cGAS/STING signaling pathway is involved in sevoflurane induced neuronal necroptosis via regulating microglia M1 polarization
Journal
Cellular signalling
Influence of coexistence of mild OSA on airway mucus hypersecretion in patients with COPD
Journal
Journal of breath research
Erythropoietin improves pulmonary hypertension by promoting the homing and differentiation of bone marrow mesenchymal stem cells in lung tissue
Characterizing the Lassa Virus Envelope Glycoprotein Membrane Proximal External Region for Its Role in Fusogenicity
Proteasome Inhibitor PS-341 Effectively Blocks Infection by the Severe Fever with Thrombocytopenia Syndrome Virus
VX-765 attenuates atherosclerosis in ApoE deficient mice by modulating VSMCs pyroptosis
Journal
Experimental Cell Research
Species
Homo sapiens, Mus musculus
Esculetin inhibits the pyroptosis of microvascular endothelial cells through NF-κB /NLRP3 signaling pathway
Journal
Archives of biochemistry and biophysics
Running Improves Muscle Mass by Activating Autophagic Flux and Inhibiting Ubiquitination Degradation in Mdx Mice
Chemopreventive effect of modified zeng-sheng-ping on oral squamous cell carcinoma by regulating tumor associated macrophages through targeting tnf alpha induced protein 6 - PMC
Journal
BMC complementary medicine and therapies
Drug-induced premature senescence model in human dental follicle stem cells.
The hematopoiesis in gill and its role in the immune response of Pacific oyster Crassostrea gigas against secondary challenge with Vibrio splendidus
Journal
Developmental and comparative immunology
Expression patterns of regulatory lncRNAs and miRNAs in muscular atrophy models induced by starvation in vitro and in vivo.
Journal
Molecular Medicine Reports
GGNBP1 ensures proper spermiogenesis in response to stress in mice
Journal
Biochemical and Biophysical Research Communications
Gallic acid promotes ferroptosis in hepatocellular carcinoma via inactivating Wnt/-catenin signaling pathway
Journal
Naunyn-Schmiedeberg's archives of pharmacology
Acute immobilization stress evokes sexually dimorphic peripheral and hippocampal neuroimmune responses in adult rats
Journal
Neuroscience letters
Role of miRNAs and lncRNAs in dexamethasone-induced myotube atrophy in vitro
PP2Ac knockdown attenuates lipotoxicity-induced pancreatic -cell dysfunction and apoptosis - PMC
Journal
Experimental and therapeutic medicine
Nec-1 alleviated the deleterious effect of CoCl2 on C2C12 myoblast differentiation and fusion via the mTOR pathway
Effects of millimeter-wave for preventing joint stiffness in the immobilized knee rat model
Saikosaponin A inhibits growth of human bladder carcinoma T24 and 5637 cells both in vitro and in vivo
Journal
Biological & pharmaceutical bulletin
The disordered C terminus of ALKBH5 promotes phase separation and paraspeckles assembly - PMC
Journal
The Journal of biological chemistry
Critical role of VHL/BICD2/STAT1 axis in crystal-associated kidney disease - PMC
Journal
Cell death & disease
STK33 phosphorylates fibrous sheath protein AKAP3/4 to regulate sperm flagella assembly in spermiogenesis
Journal
Molecular & cellular proteomics : MCP