B cell-derived anti-beta 2 glycoprotein I antibody mediates hyperhomocysteinemia-aggravated hypertensive glomerular lesions by triggering ferroptosis - PMC
Journal
Signal transduction and targeted therapy
Blood-brain barrier dysfunction mediated by the EZH2-Claudin-5 axis drives stress-induced TNF- infiltration and depression-like behaviors
Journal
Brain, behavior, and immunity
Combination of disulfiram and Copper-Cysteamine nanoparticles induces mitochondria damage and promotes apoptosis in endometrial cancer - PMC
Journal
Bioactive materials
Cooperation of MLL1 and Jun in controlling H3K4me3 on enhancers in colorectal cancer - PMC
Pathogenesis-adaptive polydopamine nanosystem for sequential therapy of ischemic stroke - PMC
Journal
Nature communications
Structural basis for botulinum neurotoxin E recognition of synaptic vesicle protein 2 - PMC
Journal
Nature communications
Astaxanthine attenuates cisplatin ototoxicity in vitro and protects against cisplatin-induced hearing loss in vivo
Journal
Acta pharmaceutica Sinica. B
A regulatory module comprising G3BP1-FBXL5-IRP2 axis determines sodium arsenite-induced ferroptosis
Journal
Journal of hazardous materials
The ORF7a protein of SARS-CoV-2 initiates autophagy and limits autophagosome-lysosome fusion via degradation of SNAP29 to promote virus replication
Design of a Haversian system-like gradient porous scaffold based on triply periodic minimal surfaces for promoting bone regeneration
Journal
Journal of advanced research
Netrin-1 promotes the immunosuppressive activity of MDSCs in colorectal cancer
Journal
Cancer immunology research
Species
Homo sapiens, Mus musculus
Modified CFBP-bFGF targeting to ischemic brain promoted the functional recovery of cerebral ischemia
Journal
Journal of controlled release : official journal of the Controlled Release Society
Antifibrotic Effects of Tetrahedral Framework Nucleic Acids by Inhibiting Macrophage Polarization and Macrophage‐myofibroblast Transition in Bladder Remodeling
Journal
Advanced healthcare materials
Bone morphogenetic protein 4 thermosensitive hydrogel inhibits corneal neovascularization by repairing corneal epithelial apical junctional complexes - PMC
Journal
Materials today. Bio
Ignored role of polyphenol in boosting reactive oxygen species generation for polyphenol/chemodynamic combination therapy - PMC
Journal
Materials today. Bio
Tofacitinib Promotes Functional Recovery after Spinal Cord Injury by Regulating Microglial Polarization via JAK/STAT Signaling Pathway - PMC
Journal
International journal of biological sciences
PRMT5 critically mediates TMAO-induced inflammatory response in vascular smooth muscle cells
Journal
Cell death & disease
Oxidative phosphorylation promotes vascular calcification in chronic kidney disease
Journal
Cell death & disease
Sulfiredoxin-1 attenuates injury and inflammation in acute pancreatitis through the ROS/ER stress/Cathepsin B axis
RhANP attenuates endotoxin-derived cognitive dysfunction through subdiaphragmatic vagus nerve-mediated gut microbiota–brain axis
Journal
J Neuroinflammation
Hepatic ZBTB22 promotes hyperglycemia and insulin resistance via PEPCK1driven gluconeogenesis
Mechanisms of Qingyi Decoction in Severe Acute Pancreatitis-Associated Acute Lung Injury via Gut Microbiota: Targeting the Short-Chain Fatty Acids-Mediated AMPK
Journal
Microbiology spectrum
The HVEM-BTLA Immune Checkpoint Restrains Murine Chronic Cholestatic Liver Injury by Regulating the Gut Microbiota
Journal
Frontiers in immunology
Identification of cuproptosis hub genes contributing to the immune microenvironment in ulcerative colitis using bioinformatic analysis and experimental verification - PMC
Journal
Frontiers in immunology
TNFα-induced IDH1 hyperacetylation reprograms redox homeostasis and promotes the chemotherapeutic sensitivity
CRISPRa-based activation of Fgf21 and Fndc5 ameliorates obesity by promoting adipocytes browning - PMC
Journal
Clinical and translational medicine
Species
Homo sapiens, Mus musculus
Integrated analysis of genes encoding ATP-dependent chromatin remodellers identifies CHD7 as a potential target for colorectal cancer therapy - PMC
Journal
Clinical and translational medicine
FOXM1 accelerates wound healing in diabetic foot ulcer by inducing M2 macrophage polarization through a mechanism involving SEMA3C/NRP2/Hedgehog …
Journal
Diabetes Res Clin Pract
Different impact of vitamin D on mitochondrial activity and morphology in normal and malignant keratinocytes, the role of genomic pathway
Journal
Free radical biology & medicine
A 1, 2, 3-Triazole Derivative of Quinazoline Exhibits Antitumor Activity by Tethering RNF168 to SQSTM1/P62
Journal
Journal of medicinal chemistry
Characterization of a polysaccharide from Sanghuangporus vaninii and its antitumor regulation via activation of the p53 signaling pathway in breast cancer MCF-7 …
Journal
Int J Biol Macromol
Species
Sanghuangporus vaninii
Oyster (Crassostrea gigas) ferritin relieves lead-induced liver oxidative damage via regulating the mitophagy
Journal
International journal of biological macromolecules
Preparation, characterization, and antioxidant and antiapoptotic activities of biosynthesized nano‑selenium by yak-derived Bacillus cereus and chitosan-encapsulated …
Journal
International journal of biological macromolecules
Facile preparation of a novel nanoemulsion based hyaluronic acid hydrogel loading with Poria cocos triterpenoids extract for wound dressing
Journal
International journal of biological macromolecules
Structural determination and pro-angiogenic effect of polysaccharide from the pollen of Typha angustifolia L.
Journal
International journal of biological macromolecules
Thiamine Supplementation Alleviates Lipopolysaccharide-Triggered Adaptive Inflammatory Response and Modulates Energy State via Suppression of NFκB/p38 MAPK/AMPK Signaling in Rumen Epithelial Cells of Goats - PMC
Journal
Antioxidants (Basel, Switzerland)
4-Octyl itaconate inhibits aerobic glycolysis by targeting GAPDH to promote cuproptosis in colorectal cancer
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
A novel small-molecular CCR5 antagonist promotes neural repair after stroke
Journal
Acta pharmacologica Sinica
Hernandezine induces autophagic cell death in human pancreatic cancer cells via activation of the ROS/AMPK signaling pathway
Journal
Acta pharmacologica Sinica
Salidroside ameliorates acetaminophen-induced acute liver injury through the inhibition of endoplasmic reticulum stress-mediated ferroptosis by activating the
Journal
Ecotoxicology and environmental safety
Recombinant measles virus vaccine rMV-Hu191 exerts an oncolytic effect on esophageal squamous cell carcinoma via caspase-3/GSDME-mediated pyroptosis - PMC
Journal
Cell death discovery
Polystyrene nanoplastics aggravated dibutyl phthalate-induced blood-testis barrier dysfunction via suppressing autophagy in male mice
Journal
Ecotoxicology and Environmental Safety
Grape seed-derived procyanidin inhibits glyphosate-induced hepatocyte ferroptosis via enhancing crosstalk between Nrf2 and FGF12
Journal
Phytomedicine : international journal of phytotherapy and phytopharmacology
Diversity-oriented synthesis of diterpenoid alkaloids yields a potent anti-inflammatory agent
Journal
Phytomedicine : international journal of phytotherapy and phytopharmacology
Sodium New Houttuyfonate Induces Apoptosis of Breast Cancer Cells via ROS/PDK1/AKT/GSK3β Axis - PMC
UCHL5 Promotes Proliferation and Migration of Bladder Cancer Cells by Activating c-Myc via AKT/mTOR Signaling - PMC
An FRET-based and ER-targeting fluorescent probe for tracking superoxide anion (O2) in the hippocampus of the depressive mouse
Circular RNA circPHKA2 Relieves OGD-Induced Human Brain Microvascular Endothelial Cell Injuries through Competitively Binding miR-574-5p to Modulate SOD2
Journal
Oxid Med Cell Longev
CBX8 promotes lung adenocarcinoma growth and metastasis through transcriptional repression of CDKN2C and SCEL
Journal
Journal of cellular physiology
EFHD1, a novel mitochondrial regulator of tumor metastasis in clear cell renal cell carcinoma - PMC
Clostridium butyricum MIYAIRI 588 alleviates periodontal bone loss in mice with diabetes mellitus
Journal
Annals of the New York Academy of Sciences
Dapagliflozin improves diabetic cognitive impairment via indirectly modulating the mitochondria homeostasis of hippocampus in diabetic mice
Journal
BioFactors (Oxford, England)
MiRNAs expression profiling of bovine (Bos taurus) testes and effect of bta-mir-146b on proliferation and apoptosis in bovine male germline stem cells
Journal
International journal of molecular sciences
Sestrin2 protects against hypoxic nerve injury by regulating mitophagy through SESN2/AMPK pathway - PMC
Journal
Frontiers in molecular biosciences
Deficient tRNA posttranscription modification dysregulated the mitochondrial quality controls and apoptosis - PMC
TOPK mediates immune evasion of renal cell carcinoma via upregulating the expression of PD-L1 - PMC
Plasma exosomes confer hypoxic pulmonary hypertension by transferring LOX-1 cargo to trigger phenotypic switching of pulmonary artery smooth muscle cells
Journal
Biochemical pharmacology
Telomere Attrition in Induced Pluripotent Stem Cell-Derived Neurons From ALS/FTD-Related C9ORF72 Repeat Expansion Carriers - PMC
Journal
Frontiers in cell and developmental biology
Fucose ameliorates the proinflammatory property of Fusobacterium nucleatum in colitis via altering its metabolism - PMC
Journal
Frontiers in cellular and infection microbiology
LncRNA15691 promotes T-ALL infiltration by upregulating CCR9 via increased MATR3 stability
Journal
Journal of leukocyte biology
Bepotastine sensitizes ovarian cancer to PARP inhibitors through suppressing NF-B-triggered SASP in cancer-associated fibroblasts
Journal
Molecular cancer therapeutics
Canagliflozin alleviates high glucose-induced peritoneal fibrosis via HIF-1α inhibition - PMC
Journal
Frontiers in pharmacology
BAK-Mediated Pyroptosis Promotes Japanese Encephalitis Virus Proliferation in Porcine Kidney 15 Cells - PMC
Searching for novel MDM2/MDMX dual inhibitors through a drug repurposing approach
Journal
Journal of enzyme inhibition and medicinal chemistry
Mesencephalic astrocyte-derived neurotrophic factor (MANF) alleviates cerebral ischemia/reperfusion injury in mice by regulating microglia polarization via A20/NF-B
Journal
International immunopharmacology
Perillaldehyde: A promising antibacterial agent for the treatment of pneumonia caused by Acinetobacter baumannii infection
Journal
International immunopharmacology
Chronic stress-induced elevation of melanin-concentrating hormone in the locus coeruleus inhibits norepinephrine production and associated with
Journal
The international journal of neuropsychopharmacology
MMP13 promotes the osteogenic potential of BMP9 by enhancing Wnt/-catenin signaling via HIF-1 upregulation in mouse embryonic fibroblasts
Journal
The international journal of biochemistry & cell biology
Improved antitumor immunity of chemotherapy in OSCC treatment by Gasdermin-E mediated pyroptosis
Journal
Apoptosis : an international journal on programmed cell death
Absence in CX3CR1 receptor signaling promotes post-ischemic stroke cognitive function recovery through suppressed microglial pyroptosis in mice - PMC
Journal
CNS neuroscience & therapeutics
Bioactive triterpenoid compounds of Poria cocos (Schw.) Wolf in the treatment of diabetic ulcers via regulating the PI3K-AKT signaling pathway
Journal
Journal of ethnopharmacology
Overexpression of IFIT2 inhibits the proliferation of chronic myeloid leukemia cells by regulating the BCR‑ABL/AKT/mTOR pathway
Journal
International journal of molecular medicine
Astragaloside IV improves pulmonary arterial hypertension by increasing the expression of CCN1 and activating the ERK1/2 pathway
Journal
Journal of cellular and molecular medicine
Species
Homo sapiens,Rattus norvegicus
The mechanism of Shenlong Jianji treatment of idiopathic pulmonary fibrosis inhibits fibroblast-to-myofibroblast transformation via the TGF-1/smads signaling
Journal
Journal of ethnopharmacology
Species
Homo sapiens,Rattus norvegicus
SuanZaoRen decoction alleviates neuronal loss, synaptic damage and ferroptosis of AD via activating DJ-1/Nrf2 signaling pathway
Journal
Journal of ethnopharmacology
Shiwei Qingwen decoction regulates TLR4/NF-κB signaling pathway and NLRP3 inflammasome to reduce inflammatory response in lipopolysaccharide-induced …
Journal
Journal of ethnopharmacology
Species
Homo sapiens,Rattus norvegicus
DiDang decoction improves mitochondrial function and lipid metabolism via the HIF-1 signaling pathway to treat atherosclerosis and hyperlipidemia
Journal
Journal of ethnopharmacology
The lactate receptor GPR81 mediates hepatic lipid metabolism and the therapeutic effect of metformin on experimental NAFLDs
Journal
European journal of pharmacology
Mechanism investigation of Shi-Xiao-San in treating blood stasis syndrome based on network pharmacology, molecular docking and in vitro/vivo pharmacological …
Journal
Journal of ethnopharmacology
-Lipoic acid improves mitochondrial biogenesis and dynamics by enhancing antioxidant and inhibiting Wnt/Ca2+ pathway to relieve fluoride-induced hepatotoxic
Journal
Chemico-biological interactions
MiR-216a reduces apoptosis of pulmonary microvascular endothelial cells in COPD by targeting DNMT1 - PMC
Journal
Tobacco induced diseases
Dengue virus M and E proteins belonging to genotype II (Cosmopolitan) of serotype 2 are influenced by the nature of M residue 36
Journal
The Journal of general virology
Remimazolam attenuates inflammation and kidney fibrosis following folic acid injury
Journal
European journal of pharmacology
Transcription factors SltA and CrzA reversely regulate calcium homeostasis under calcium-limited conditions
Journal
Applied and environmental microbiology
Species
A. fumigatus strains
A Novel Gene Pair CSTF2/DPE2A Impacts Prognosis and Cell Cycle of Hepatocellular Carcinoma - PMC
Journal
Journal of hepatocellular carcinoma
Constructing a signature based on the SIRT family to help the prognosis and treatment sensitivity in glioma patients - PMC
Journal
Frontiers in genetics
The Comprehensive Role of High Mobility Group Box 1 (HMGB1) Protein in Different Tumors: A Pan-Cancer Analysis - PMC
Journal
Journal of inflammation research
Transcriptomic analysis reveals the effects of maternal selenium deficiency on placental transport, hormone synthesis, and immune response in mice
Journal
Metallomics : integrated biometal science
MiR-1 is a critical regulator of chondrocyte proliferation and hypertrophy by inhibiting Indian hedgehog pathway during postnatal endochondral ossification in miR-1 …
Deficiency of spns1 Exacerbates Per-and Polyfluoroalkyl Substances Mediated Hepatic Toxicity and Steatosis in Zebrafish (Danio rerio)
EPS15-AS1 Inhibits AKR1B1 Expression to Enhance Ferroptosis in Hepatocellular Carcinoma Cells - PMC
Wnt/β-Catenin Promotes the Osteoblastic Potential of BMP9 Through Down-Regulating Cyp26b1 in Mesenchymal Stem Cells
Journal
Tissue engineering and regenerative medicine
Development and verification of a deep learning-based m6A modification model for clinical prognosis prediction of renal cell carcinoma
Journal
Journal of cancer research and clinical oncology
Application
WB, IHC, RIP, RT-PCR
Sanqi Qushi Granule Alleviates Proteinuria and Podocyte Damage in NS Rat: A Network Pharmacology Study and in vivo Experimental Validation - PMC
Journal
Drug design, development and therapy
MiR196a-5p in extracellular vesicles released from human nasopharyngeal carcinoma enhance the phagocytosis and secretion of microglia by targeting ROCK1
DDX41 regulates the expression and alternative splicing of genes involved in tumorigenesis and immune response
GC‑MSC‑derived circ_0024107 promotes gastric cancer cell lymphatic metastasis via fatty acid oxidation metabolic reprogramming mediated by the miR‑5572/6855 …
MiR-95-3p/EPM2A/MMP2 contributes to the pathogenesis of severe preeclampsia through the regulation of trophoblast biological behaviour
Journal
Archives of biochemistry and biophysics
LINC01572 promotes triplenegative breast cancer progression through EIF4A3mediated catenin mRNA nuclear exportation
Journal
Environmental toxicology
METTL14 represses osteoclast formation to ameliorate osteoporosis via enhancing GPX4 mRNA stability
Journal
Environmental toxicology
Promotion Effect of Angelica Sinensis Extract on Angiogenesis of Chicken Preovulatory Follicles in Vitro
Modified rougan decoction alleviates lipopolysaccharide-enrofloxacin-induced hepatotoxicity via activating the Nrf2/ARE pathway in chicken - PMC
Evaluation of topical methylene blue nanoemulsion for wound healing in diabetic mice - PMC
Journal
Pharmaceutical biology
Class Ⅰ histone deacetylase inhibitor regulate of Mycobacteria–Driven guanylate-binding protein 1 gene expression
Journal
Microbial pathogenesis
URP20 improves corneal injury caused by alkali burns combined with pathogenic bacterial infection in rats
Journal
Experimental eye research
O-GlcNAcylation regulates HIF-1 and induces mesothelial-mesenchymal transition and fibrosis of human peritoneal mesothelial cells - PMC
BMP4 inhibits corneal neovascularization by interfering with tip cells in angiogenesis
Journal
Experimental eye research
Fibrinogen promotes gallbladder cancer cell metastasis and extravasation by inducing ICAM1 expression
Journal
Medical oncology (Northwood, London, England)
A novel selective estrogen receptor degrader induces cell cycle arrest in breast cancer via ERα degradation and the autophagy-lysosome pathway
Journal
Bioorganic & medicinal chemistry
Aldolase A Promotes Colorectal Cancer Progression through Targeting COPS6 and Regulating MAPK Signaling Pathway - PMC
Effects of Repetitive Transcranial Magnetic Stimulation on Pallidum GABAergic Neurons and Motor Function in Rat Models of Kernicterus - PMC
LIGHT (TNFSF14) inhibits glucose uptake of adipocytes by downregulating GLUT4 expression via AKT signaling pathway
Journal
Biochem Biophys Res Commun
Kallikrein-related peptidase 10 predicts prognosis and mediates tumor immunomodulation in colorectal cancer
Journal
Biochemical and biophysical research communications
Astragaloside IV Alleviates Brain Injury Induced by Hypoxia via the Calpain-1 Signaling Pathway - PMC
HSP60 knockdown suppresses proliferation in colorectal cancer cells via activating the adenine/AMPK/mTOR signaling pathway
Ru360 Alleviates Postoperative Cognitive Dysfunction in Aged Mice by Inhibiting MCU-Mediated Mitochondrial Dysfunction - PMC
Journal
Neuropsychiatric disease and treatment
Comparison of the differentiation abilities of bone marrow?derived mesenchymal stem cells and adipose?derived mesenchymal stem cells toward nucleus pulposus-like cells in three?dimensional culture
RRM2 regulates osteogenesis of mouse embryo fibroblasts via the Wnt/β‑catenin signaling pathway
Journal
Experimental and therapeutic medicine
Wild Bitter Melon Extract Abrogates Hypoxia-Induced Cell Death via the Regulation of Ferroptosis, ER Stress, and Apoptosis in Microglial BV2 Cells
Journal
Evidence-based complementary and alternative medicine : eCAM
Rabeprazole inhibits inflammatory reaction by inhibition of cell pyroptosis in gastric epithelial cells
Journal
BMC Pharmacol Toxicol
Rubus chingii Hu relieved the polycystic ovary syndrome with enhanced insulin sensitivity through inhibiting TXNIP/NLRP3 inflammasome signaling
Journal
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
Study on the autophagy-related mechanism of puerarin in improving the cognitive impairment induced by alcohol in female mice
Engeletin ameliorates sevoflurane‐induced cognitive impairment by activating PPAR‐gamma in neonatal mice
Journal
Neuropathology : official journal of the Japanese Society of Neuropathology
A multi-omics analysis of viral nucleic acid poly(I:C) responses to mammalian testicular stimulation - PMC
Developmental potency of human ES cell-derived mesenchymal stem cells revealed in mouse embryos following blastocyst injection
A spatially defined human Notch receptor interaction network reveals Notch intracellular storage and Ataxin-2-mediated fast recycling
The deubiquitinase OTUD4 inhibits the expression of antimicrobial peptides in Paneth cells to support intestinal inflammation and bacterial infection - PMC
Inhibiting 3βHSD1 to eliminate the oncogenic effects of progesterone in prostate cancer
Journal
Cell reports. Medicine