Fertilized egg cells secrete endopeptidases to avoid polytubey
Species
Arabidopsis thaliana
Cdh1 regulates craniofacial development via APC-dependent ubiquitination and activation of Goosecoid.
The ZmWAKL-ZmWIK-ZmBLK1-ZmRBOH4 module provides quantitative resistance to gray leaf spot in maize - PMC
Direct Phosphorylation and Stabilization of MYC by Aurora B Kinase Promote T-cell Leukemogenesis
Heat shock protein DNAJA2 regulates transcription-coupled repair by triggering CSB degradation via chaperone-mediated autophagy - PMC
Jasmonate signaling enhances RNA silencing and antiviral defense in rice
Journal
Cell host & microbe
bHLH121 functions as a direct link that facilitates the activation of FIT by bHLH IVc transcription factors for maintaining Fe homeostasis in Arabidopsis
MPK14-mediated auxin signaling controls lateral root development via ERF13-regulated very-long-chain fatty acid biosynthesis
Species
Arabidopsis thaliana
Reversible Histone H2B Monoubiquitination Fine-tunes Abscisic Acid Signaling and Drought Response in Rice.
A Phytophthora capsici RXLR effector targets and inhibits a plant PPIase to suppress endoplasmic reticulum-mediated immunity
Species
Phytophthora capsici
SPOP-containing complex regulates SETD2 stability and H3K36me3-coupled alternative splicing
Journal
Nucleic Acids Research
Usp7 regulates Hippo pathway through deubiquitinating the transcriptional coactivator Yorkie.
Journal
Nature communications
GP73 is a TBC-domain Rab GTPase-activating protein contributing to the pathogenesis of non-alcoholic fatty liver disease without obesity
The E3 ligase MREL57 modulates microtubule stability and stomatal closure in response to ABA
Species
Arabidopsis thaliana
SMURF2 regulates bone homeostasis by disrupting SMAD3 interaction with vitamin D receptor in osteoblasts
Journal
Nature communications
Allelic variation of TaWD40-4B.1 contributes to drought tolerance by modulating catalase activity in wheat - PMC
Journal
Nature communications
Species
Saccharomyces cerevisiae
URI alleviates tyrosine kinase inhibitors-induced ferroptosis by reprogramming lipid metabolism in p53 wild-type liver cancers - PMC
Journal
Nature communications
Glutaredoxins regulate maize inflorescence meristem development via redox control of TGA transcriptional activity
Somatic variants of MAP3K3 are sufficient to cause cerebral and spinal cord cavernous malformations
Journal
Brain : a journal of neurology
VGLL4 promotes osteoblast differentiation by antagonizing TEADs-inhibited Runx2 transcription
Microglial Ffar4 deficiency promotes cognitive impairment in the context of metabolic syndrome - PMC
ERanchored CRTH2 antagonizes collagen biosynthesis and organ fibrosis via binding LARP6
Non-canonical AUX/IAA protein IAA33 competes with canonical AUX/IAA repressor IAA5 to negatively regulate auxin signaling.
Species
Arabidopsis thaliana
ABRO1 promotes NLRP3 inflammasome activation through regulation of NLRP3 deubiquitination.
ZmTE1 promotes plant height by regulating intercalary meristem formation and internode cell elongation in maize
Journal
Plant biotechnology journal
Dual regulations of cell cycle regulator DPa by auxin in Arabidopsis root distal stem cell maintenance
Journal
Proceedings of the National Academy of Sciences of the United States of America
Species
Arabidopsis thaliana
CENP-I directly targets centromeric DNA to support CENP-A deposition and centromere maintenance - PMC
Journal
Proceedings of the National Academy of Sciences of the United States of America
Integrated Regulation of Apical Hook Development by Transcriptional Coupling of EIN3/EIL1 and PIFs in Arabidopsis.
Species
Arabidopsis thaliana
PHYTOCHROME INTERACTING FACTOR 4 regulates microtubule organization to mediate high temperatureinduced hypocotyl elongation in Arabidopsis
Species
Arabidopsis thaliana
Inhibition of the transcription factor ZNF281 by SUFU to suppress tumor cell migration
Journal
Cell death and differentiation
MAC3A and MAC3B mediate degradation of the transcription factor ERF13 and thus promote lateral root emergence
Species
Arabidopsis thaliana
An LRH-RSL4 feedback regulatory loop controls the determinate growth of root hairs in Arabidopsis
Journal
Current biology : CB
Species
Arabidopsis thaliana
Maternal EHMT2 is essential for homologous chromosome segregation by regulating Cyclin B3 transcription in oocyte meiosis - PMC
Journal
International journal of biological sciences
SETDB2 promoted breast cancer stem cell maintenance by interaction with and stabilization of ΔNp63α protein
A Highly Accumulated Secretory Protein from Cotton Bollworm Interacts with bHLHs to dampen Plant Defense
Journal
The New phytologist
Species
Helicoverpa armigera
Phytophthora infestans RXLR effector PITG20303 targets a potato MKK1 protein to suppress plant immunity
Journal
The New phytologist
Species
Nicotiana benthamiana
POH1 induces Smad3 deubiquitination and promotes lung cancer metastasis
The interaction between STING and NCOA4 exacerbates lethal sepsis by orchestrating ferroptosis and inflammatory responses in macrophages - PMC
Journal
Cell death & disease
SUMOylated IL-33 in the nucleus stabilizes the transcription factor IRF1 in hepatocellular carcinoma cells to promote immune escape
SIZ1 negatively regulates aluminum resistance by mediating the STOP1–ALMT1 pathway in Arabidopsis
Journal
Journal of integrative plant biology
Species
Arabidopsis thaliana
Ethylene promotes seed iron storage during Arabidopsis seed maturation via ERF95 transcription factor
Journal
J Integr Plant Biol
Species
Arabidopsis thaliana
Oryza sativa Fer-like fe deficiency-induced transcription factor (OsFIT/OsbHLH156) interacts with OsIRO2 to regulate iron homeostasis
Journal
Journal of Integrative Plant Biology
The role of Class II KNOX family in controlling compound leaf patterning in Medicago truncatula
Journal
Journal of integrative plant biology
Species
Medicago truncatula
RNF152 positively regulates TLR/IL-1R signaling by enhancing MyD88 oligomerization
DDX5 inhibits inflammation by modulating m6A levels of TLR2/4 transcripts during bacterial infection
An ULK1/2PXN mechanotransduction pathway suppresses breast cancer cell migration
MPK3/6‐induced degradation of ARR1/10/12 promotes salt tolerance in Arabidopsis
Species
Arabidopsis thaliana
USP29 coordinates MYC and HIF1 stabilization to promote tumor metabolism and progression
PM2. 5 contributed to pulmonary epithelial senescence and ferroptosis by regulating USP3-SIRT3-P53 axis
Journal
Free radical biology & medicine
Histone demethylase LSD1 promotes RIG-I poly-ubiquitination and anti-viral gene expression
Knockdown of HSP110 attenuates hypoxia-induced pulmonary hypertension in mice through suppression of YAP/TAZ-TEAD4 pathway - PMC
Journal
Respiratory research
An RxLR effector from Plasmopara viticola suppresses plant immunity in grapevine by targeting and stabilizing VpBPA1
Journal
The Plant journal : for cell and molecular biology
Species
Lactobacillus vitis
Discovery of bipyridine amide derivatives targeting pRXRα-PLK1 interaction for anticancer therapy
Journal
European journal of medicinal chemistry
Transition Zone1 Negatively Regulates Arabidopsis Aluminum Resistance Through Interaction With Aconitases
Journal
Frontiers in plant science
Species
Arabidopsis thaliana
Identification of CDPKs involved in TaNOX7 mediated ROS production in wheat - PMC
Journal
Frontiers in plant science
Cyclophilin A Inhibits Human Respiratory Syncytial Virus (RSV) Replication by Binding to RSV-N through Its PPIase Activity
p38MAPK-and GSK3-Mediated Phosphorylation of Snakehead Vesiculovirus Phosphoprotein at Threonine 160 Facilitates Viral Replication
Journal
Journal of virology
Structure of the Spring Viraemia of Carp Virus Ribonucleoprotein Complex Reveals Its Assembly Mechanism and Application in Antiviral Drug Screening
Journal
Journal of virology
Oral or intranasal immunization with recombinant Lactobacillus plantarum displaying head domain of Swine Influenza A virus hemagglutinin protects mice from H1N1 virus - PMC
Journal
Microbial cell factories
IRBIT activates NBCe1‐B by releasing the auto‐inhibition module from the transmembrane domain.
The Expression of P35 Plays a Key Role in the Difference in Apoptosis Induced by AcMNPV Infection in Different Spodoptera exigua Cell Lines - PMC
Journal
International journal of molecular sciences
A helicase-independent role of DHX15 promotes MYC stability and acute leukemia cell survival - PMC
DAB2IP suppresses invadopodia formation through destabilizing ALK by interacting with USP10 in breast cancer - PMC
KLHL7 promotes hepatocellular carcinoma progression and molecular therapy resistance by degrading RASA2 - PMC
Genetic ablation of diabetes-associated gene Ccdc92 reduces obesity and insulin resistance in mice - PMC
Epilepsy gene prickle ensures neuropil glial ensheathment through regulating cell adhesion molecules - PMC
Rbm24a Is Necessary for Hair Cell Development Through Regulating mRNA Stability in Zebrafish
Journal
Front Cell Dev Bio
BPOZ-2 is a negative regulator of the NLPR3 inflammasome contributing to SARS-CoV-2-induced hyperinflammation - PMC
Journal
Frontiers in cellular and infection microbiology
IAA3-mediated repression of PIF proteins coordinates light and auxin signaling in Arabidopsis
Species
Arabidopsis thaliana
CRHBP is degraded via autophagy and exerts anti-hepatocellular carcinoma effects by reducing cyclin B2 expression and dissociating cyclin B2-CDK1 complex
Journal
Cancer gene therapy
Host Desmin Interacts with RABV Matrix Protein and Facilitates Virus Propagation - PMC
The Raf‐like kinase Raf36 negatively regulates plant resistance against the oomycete pathogen Phytophthora parasitica by targeting MKK2
Species
Arabidopsis thaliana
RIR1 represses plant immunity by interacting with mitochondrial complex I subunit in rice
Potato StMPK7 is a downstream component of StMKK1 and promotes resistance to the oomycete pathogen Phytophthora infestans
Optimum Fermentation Conditions for Bovine Lactoferricin-Lactoferrampin-Encoding LimosiLactobacillus reuteri and Regulation of Intestinal Inflammation - PMC
Journal
Foods (Basel, Switzerland)
Species
Sus scrofa domesticus
LIM and Cysteine-Rich Domains 1 Promotes Transforming Growth Factor 1Induced EpithelialMesenchymal Transition in Human Kidney 2 Cells
Journal
Laboratory investigation; a journal of technical methods and pathology
Coordinated regulation of the ribosome and proteasome by PRMT1 in the maintenance of neural stemness in cancer cells and neural stem cells
STAT3 controls osteoclast differentiation and bone homeostasis by regulating NFATc1 transcription
Journal
The Journal of Biological Chemistry
The SCFβ-TrCP E3 Ubiquitin Ligase Regulates Immune Receptor Signaling by Targeting the Negative Regulatory Protein TIPE2
Journal
Journal of immunology (Baltimore, Md. : 1950)
hnRNPA1 impedes snakehead vesiculovirus replication via competitively disrupting viral phosphoprotein-nucleoprotein interaction and degrading viral phosphoprotein - PMC
Species
Ictalurus punctatus
pVHL interacts with Ceramide kinase like (CERKL) protein and ubiquitinates it for oxygen dependent proteasomal degradation
Journal
Cellular signalling
HSP90 Inhibitor Ganetespib (STA-9090) Inhibits Tumor Growth in c-Myc-Dependent Esophageal Squamous Cell Carcinoma
Journal
Oncotargets and Therapy
GmWRKY17-mediated transcriptional regulation of GmDREB1D and GmABA2 controls drought tolerance in soybean
Journal
Plant molecular biology
Species
Arabidopsis thaliana
Activation of mouse NBCe1-B by Xenopus laevis and mouse IRBITs: Role of the variable Nt appendage of IRBITs
Journal
Biochimica et Biophysica acta. Biomembranes
ABRO1 stabilizes the deubiquitinase BRCC3 through inhibiting its degradation mediated by the E3 ubiquitin ligase WWP2
Cloning and functional characterization of IRAK1 from rainbow trout (Oncorhynchus mykiss)
Fam198a, a member of secreted kinase, secrets through caveolae biogenesis pathway. (PMID:30188967)
Journal
Acta Biochimica et Biophysica Sinica
Clnk plays a role in TNF-alpha-induced cell death in murine fibrosarcoma cell line L929
Journal
Biochemical And Biophysical Research Communications
Suppression of NF-B signaling by Pseudorabies virus DNA polymerase processivity factor UL42 via recruiting SOCS1 to promote the ubiquitination degradation of
Journal
Veterinary microbiology
STOP1 attenuates the auxin response to maintain root stem cell niche identity
Species
Arabidopsis thaliana
Ccdc85c-Par3 condensates couple cell polarity with Notch to control neural progenitor proliferation
Type I interferon/STAT1 signaling regulates UBE2M-mediated antiviral innate immunity in a negative feedback manner
Neural stemness unifies cell tumorigenicity and pluripotent differentiation potential - PMC
Journal
The Journal of biological chemistry
Inhibition of SIRT2 promotes APP acetylation and ameliorates cognitive impairment in APP/PS1 transgenic mice
Multiple Alleles Encoding Atypical NLRs with Unique Central Tandem Repeats in Rice Confer Resistance to Xanthomonas oryzae pv. oryzae