A Rational Design of Metal-Organic Framework Nanozyme with High-Performance Copper Active Centers for Alleviating Chemical Corneal Burns - PMC
Journal
Nano-micro letters
TS2021, a thirdgeneration oncolytic adenovirus that carried Ki67 promoter, TGF2 5 UTR, and IL 15 against experimental glioblastoma
Journal
Journal of medical virology
Species
Bos taurus,Homo sapiens
Unspliced XBP1 Counteracts -Catenin to Inhibit Vascular Calcification
Journal
Circulation Research
A dopamine-precursor-based nanoprodrug for in-situ drug release and treatment of acute liver failure by inhibiting NLRP3 inflammasome and facilitating liver regeneration
P-gp expression inhibition mediates placental glucocorticoid barrier opening and fetal weight loss
Species
Homo sapiens, Mus musculus, Rattus norvegicus
Usp8 promotes tumor cell migration through activating the JNK pathway
Journal
Cell death & disease
Cerium oxide nanoparticles-carrying human umbilical cord mesenchymal stem cells counteract oxidative damage and facilitate tendon regeneration - PMC
Journal
Journal of nanobiotechnology
Lnc90386 Sponges miR-33-5p to Mediate Mycoplasma gallisepticum-Induced Inflammation and Apoptosis in Chickens via the JNK Pathway - PMC
Journal
Frontiers in immunology
Domain fusion TLR2-4 enhances the autophagy-dependent clearance of Staphylococcus aureus in the genetic engineering goat - PMC
Perilipin 5 Protects against Cellular Oxidative Stress by Enhancing Mitochondrial Function in HepG2 Cells
FGF4 promotes skin wound repair through p38 MAPK and GSK3β-mediated stabilization of Slug
Journal
The Journal of investigative dermatology
Cordycepin protects islet β-cells against glucotoxicity and lipotoxicity via modulating related proteins of ROS/JNK signaling pathway
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
JNK molecule is a toxic target for IPEC-J2 cell barrier damage induced by T-2 toxin
Journal
Ecotoxicology and environmental safety
FK866 attenuates sepsis-induced acute lung injury through c-jun-N-terminal kinase (JNK)-dependent autophagy
Polysaccharides from Hericium erinaceus Fruiting Bodies: Structural Characterization, Immunomodulatory Activity and Mechanism - PMC
Species
Homo sapiens, Mus musculus
Glabridin Ameliorates Alcohol-Caused Liver Damage by Reducing Oxidative Stress and Inflammation via p38 MAPK/Nrf2/NF-κB Pathway - PMC
Effects and Mechanisms of Rhus chinensis Mill. Fruits on Suppressing RANKL-Induced Osteoclastogenesis by Network Pharmacology and Validation in RAW264.7 Cells
Sophflarine A, a novel matrine-derived alkaloid from Sophora flavescens with therapeutic potential for non-small cell lung cancer through ROS-mediated pyroptosis …
Journal
Phytomedicine : international journal of phytotherapy and phytopharmacology
Improved colonic inflammation by nervonic acid via inhibition of NF-κB signaling pathway of DSS-induced colitis mice
Journal
Phytomedicine : international journal of phytotherapy and phytopharmacology
Total terpenoids of Inula japonica activated the Nrf2 receptor to alleviate the inflammation and oxidative stress in LPS-induced acute lung injury
Journal
Phytomedicine : international journal of phytotherapy and phytopharmacology
In vivo hepatoprotective activity and the underlying mechanism of chebulinic acid from Terminalia chebula fruit
Journal
Phytomedicine : international journal of phytotherapy and phytopharmacology
Inhibition of Sema4D attenuates pressure overload-induced pathological myocardial hypertrophy via the MAPK/NF-B/NLRP3 pathways
Journal
Biochimica et biophysica acta. Molecular basis of disease
The preventive effect and underlying mechanism of Rhus chinensis Mill. fruits on dextran sulphate sodium-induced ulcerative colitis in mice
Dual Role of Mitogen-Activated Protein Kinase 8 Interacting Protein-1 in Inflammasome and Pancreatic -Cell Function - PMC
Journal
International journal of molecular sciences
Species
Homo sapiens, Rattus norvegicus
ARP2/3 Regulates Fatty Acid Synthesis by Modulating Lipid Droplets Motility - PMC
Journal
International journal of molecular sciences
Characterizations and the Mechanism Underlying Osteogenic Activity of Peptides from Enzymatic Hydrolysates of Stichopus japonicus
Biotransformation of 18β-Glycyrrhetinic Acid by Human Intestinal Fungus Aspergillus niger RG13B1 and the Potential Anti-Inflammatory Mechanism of Its Metabolites
Journal
Journal of agricultural and food chemistry
ADAMTS8 Promotes Cardiac Fibrosis Partly Through Activating EGFR Dependent Pathway
Journal
Frontiers in cardiovascular medicine
Species
Homo sapiens,Rattus norvegicus
Nicotinamide mononucleotide-elicited NAMPT signaling activation aggravated adjuvant-induced arthritis in rats by affecting peripheral immune cells differentiation
Journal
Int Immunopharmacol
Dexmedetomidine attenuates hepatic ischemia-reperfusion injury-induced apoptosis via reducing oxidative stress and endoplasmic reticulum stress
Journal
International immunopharmacology
Puerarin improves diabetic wound healing via regulation of macrophage M2 polarization phenotype - PMC
Expression Silencing of Mitogen-Activated Protein Kinase 8 Interacting Protein-1 Conferred Its Role in Pancreatic β-Cell Physiology and Insulin Secretion - PMC
Non-Esterified Fatty Acid Induces ER Stress-Mediated Apoptosis via ROS/MAPK Signaling Pathway in Bovine Mammary Epithelial Cells - PMC
The water-soluble subfraction from Artemisia argyi alleviates LPS-induced inflammatory responses via multiple pathways and targets in vitro and in vivo
Journal
Journal of ethnopharmacology
Phosphorylated chitosan hydrogels inducing osteogenic differentiation of osteoblasts via JNK and p38 signaling pathways
Journal
ACS biomaterials science & engineering
Structural modification of natural axinelline A: Achieving reduced colitis side effects through balanced COX inhibition
Journal
Bioorganic chemistry
Inhibitory effects of Schisandrin C on collagen behavior in pulmonary fibrosis - PMC
Journal
Scientific reports
Dysfunctional TLR1 reduces the therapeutic efficacy of chemotherapy by attenuating HMGB1-mediated antitumor immunity in locally advanced colorectal cancer - PMC
Journal
Scientific reports
DUSP1 mediates BCG induced apoptosis and inflammatory response in THP-1 cells via MAPKs/NF-κB signaling pathway - PMC
Journal
Scientific reports
Cepharanthine Exerts Antioxidant and Anti-Inflammatory Effects in Lipopolysaccharide (LPS)-Induced Macrophages and DSS-Induced Colitis Mice - PMC
Journal
Molecules (Basel, Switzerland)
Paclitaxel Induces the Apoptosis of Prostate Cancer Cells via ROS-Mediated HIF-1α Expression - PMC
Journal
Molecules (Basel, Switzerland)
PKD knockdown mitigates Ang II-induced cardiac hypertrophy and ferroptosis via the JNK/P53 signaling pathway
Journal
Cellular signalling
Species
Mus musculus,Rattus norvegicus
Inula japonica ameliorated the inflammation and oxidative stress in LPS-induced acute lung injury through the MAPK/NF-κB and Keap1/Nrf2 signalling pathways
Journal
The Journal of pharmacy and pharmacology
Vascular Adventitial Fibroblasts-Derived FGF10 Promotes Vascular Smooth Muscle Cells Proliferation and Migration in vitro and the Neointima Formation in vivo
Legumain Inhibitor Prevents Breast Cancer Bone Metastasis by Attenuating Osteoclast Differentiation and Function
Species
Homo sapiens, Mus musculus
PSMD1 and PSMD2 regulate HepG2 cell proliferation and apoptosis via modulating cellular lipid droplet metabolism
Journal
BMC Molecular Biology
lncRNA IL-17RA-1 Attenuates LPS-Induced Sepsis via miR-7847-3p/PRKCG-Mediated MAPK Signaling Pathway - PMC
Journal
Mediators of inflammation
Suppression of mir-1505p attenuates the anti-inflammatory effect of glucocorticoids in mice with ulcerative colitis
Journal
Molecular immunology
Oridonin Attenuates Thioacetamide-Induced Osteoclastogenesis Through MAPK/NF-κB Pathway and Thioacetamide-Inhibited Osteoblastogenesis Through …
Journal
Calcified tissue international
Species
Mus musculus,Rattus norvegicus
Exploring cisplatin resistance in ovarian cancer through integrated bioinformatics approach and overcoming chemoresistance with sanguinarine
Journal
American Journal of Translational Research
The novel Nsp9-interacting host factor H2BE promotes PEDV replication by inhibiting endoplasmic reticulum stress-mediated apoptosis - PMC
Journal
Veterinary research
Species
Chlorocebus aethiops
The Effects of Inorganic Phosphorus Levels on Phosphorus Utilization, Local Bone-Derived Regulators, and BMP/MAPK Pathway in Primary Cultured Osteoblasts of Broiler Chicks
Journal
Frontiers in veterinary science
Ginsenoside Rg1 treatment alleviates renal fibrosis by inhibiting the NOX4-MAPK pathway in T2DM mice - PMC
Inhibited Expression of NLRP12 Promotes the Development of Triple-Negative Breast Cancer by Activating the NF-B Pathway
Journal
Cell biochemistry and biophysics
Echinacoside Protects Against Dysfunction of Spermatogenesis Through the MAPK Signaling Pathway
In vitro and in silico analysis of ‘Taikong blue lavender essential oil in LPS-induced HaCaT cells and RAW264.7 murine macrophages - PMC
Journal
BMC complementary medicine and therapies
Species
Homo sapiens, Mus musculus
PP2Ac knockdown attenuates lipotoxicity-induced pancreatic -cell dysfunction and apoptosis - PMC
Journal
Experimental and therapeutic medicine
Autophagy inhibitors alleviate Japanese encephalitis virus-induced cerebral inflammation in mice
Journal
Archives of virology
GSPT1 Functions as a Tumor Promoter in Human Liver Cancer
Journal
Current medical science
Schisandrin B inhibits α-melanocyte-stimulating hormone-induced melanogenesis in B16F10 cells via downregulation of MAPK and CREB signaling pathways
Journal
Bioscience, biotechnology, and biochemistry
Hypoglycemic effect of acidic polysaccharide from schisandra chinensis on T2D rats induced by high-fat diet combined with STZ
Journal
Biological & pharmaceutical bulletin
Dexmedetomidine Attenuates LPS-Stimulated Alveolar Type II Cells' Injury through Upregulation of miR-140-3p and Partial Suppression of PD-L1 Involving Inactivating JNK-Bnip3 Pathway - PMC
Journal
Canadian respiratory journal
Inhibition of Calpain Alleviates Apoptosis in Coxsackievirus B3-induced Acute Virus Myocarditis Through Suppressing Endoplasmic Reticulum Stress
Journal
International heart journal
Combining an in silico approach with an animal experiment to investigate the protective effect of troxerutin for treating acute lung injury
Journal
BMC complementary and alternative medicine