Structural insights into a shared mechanism of human STING activation by a potent agonist and an autoimmune disease-associated mutation - PMC
Engineering Extracellular Vesicles Enriched with Palmitoylated ACE2 as COVID19 Therapy
Targeting specific DNA G-quadruplexes with CRISPR-guided G-quadruplex-binding proteins and ligands
Journal
Nature cell biology
Protein arginine methyltransferase 5 mediates arginine symmetric dimethylation of influenza A virus PB2 and supports viral replication
Journal
Journal of medical virology
Biodegradation of highly crystallized poly(ethylene terephthalate) through cell surface codisplay of bacterial PETase and hydrophobin - PMC
Journal
Nature communications
Species
Saccharomyces cerevisiae
Holo-Lactoferrin Modified Liposome for Relieving Tumor Hypoxia and Enhancing Radiochemotherapy of Cancer.
Spatial Heterogeneity Directs Energy Dissipation in Condylar Fibrocartilage
Journal
Small (Weinheim an der Bergstrasse, Germany)
Haploid-genetic screening of trophectoderm specification identifies Dyrk1a as a repressor of totipotent-like status - PMC
Gestational dexamethasone exposure impacts hippocampal excitatory synaptic transmission and learning and memory function with transgenerational effects
Journal
Acta pharmaceutica Sinica. B
TMED2 Potentiates Cellular IFN Responses to DNA Viruses by Reinforcing MITA Dimerization and Facilitating Its Trafficking.
GRK5 functions as an oncogenic factor in non-small-cell lung cancer
Journal
Cell Death and Disease
B602L-Fc fusion protein enhances the immunogenicity of the B602L protein of the African swine fever virus - PMC
Journal
Frontiers in immunology
Species
Spodoptera frugiperdaSus scrofa
Discovery and biological evaluation of a potent small molecule CRM1 inhibitor for its selective ablation of extranodal NK/T cell lymphoma - PMC
The crosstalk between DRP1-dependent mitochondrial fission and oxidative stress triggers hepatocyte apoptosis induced by silver nanoparticles
Lactoferrin ameliorated obesity-induced endothelial dysfunction by inhibiting the Tak1/IL-18/eNOS pathway between PVAT and vascular endothelium
Journal
Free radical biology & medicine
MORN4 protects cardiomyocytes against ischemic injury via MFN2-mediated mitochondrial dynamics and mitophagy
Journal
Free radical biology & medicine
Species
Rattus norvegicus,Mus musculus,Homo sapiens
Reprogrammed mesenchymal stem cells derived from iPSCs promote bone repair in steroid-associated osteonecrosis of the femoral head
Journal
Stem Cell Res Ther
Overexpression of long noncoding RNA DUXAP8 inhibits ER-phagy through activating AKT/mTOR signaling and contributes to preeclampsia - PMC
Journal
Cellular and molecular life sciences : CMLS
Mitophagy defect mediates the agingassociated hallmarks in HutchinsonGilford progeria syndrome
Fibroblasts inhibit osteogenesis by regulating nuclear-cytoplasmic shuttling of YAP in mesenchymal stem cells and secreting DKK1 - PMC
Journal
Biological research
Polysaccharide from spore of Ganoderma lucidum ameliorates paclitaxel-induced intestinal barrier injury: Apoptosis inhibition by reversing microtubule polymerization
Journal
Biomed Pharmacother
HACE1 negatively regulates neuroinflammation through ubiquitylating and degrading Rac1 in Parkinson's disease models
Journal
Acta Pharmacol Sin
Species
Homo sapiens, Mus musculus
Heparanase induces necroptosis of microvascular endothelial cells to promote the metastasis of hepatocellular carcinoma
Total flavonoids of Selaginella tamariscina (P.Beauv.) Spring ameliorates doxorubicin-induced cardiotoxicity by modulating mitochondrial dysfunction and endoplasmic reticulum stress via activating MFN2/PERK
Journal
Phytomedicine : international journal of phytotherapy and phytopharmacology
p53 and HuR combinatorially control the biphasic dynamics of microRNA-125b in response to genotoxic stress - PMC
Journal
Communications biology
Gardenia jasminoides J. Ellis extract alleviated white matter damage through promoting the differentiation of oligodendrocyte precursor cells via suppressing neuroinflammation
DnaJA2 interacts with Japanese encephalitis virus NS3 via its C-terminal to promote viral infection - PMC
Synergistic Effect of QNZ, an Inhibitor of NF-B Signaling, and Bone Morphogenetic Protein 2 on Osteogenic Differentiation in Mesenchymal Stem Cells through Fibroblast-Induced Yes-Associated Protein Activation - PMC
Journal
International journal of molecular sciences
Metal Ion Periplasmic-Binding Protein YfeA of Glaesserella parasuis Induces the Secretion of Pro-Inflammatory Cytokines of Macrophages via MAPK and NF-κB Signaling through TLR2 and TLR4 - PMC
Journal
International journal of molecular sciences
Apol9a regulates myogenic differentiation via the ERK1/2 pathway in C2C12 cells - PMC
Journal
Frontiers in pharmacology
Zoledronic acid promotes TLR-4-mediated M1 macrophage polarization in bisphosphonate-related osteonecrosis of the jaw.
Type II Grass Carp Reovirus Infects Leukocytes but Not Erythrocytes and Thrombocytes in Grass Carp ( Ctenopharyngodon idella)
Pathological Features of Echovirus-11-Associated Brain Damage in Mice Based on RNA-Seq Analysis
Virus-like particles of chimeric recombinant porcine circovirus type 2 as antigen vehicle carrying foreign epitopes
Type II Grass Carp Reovirus Rapidly Invades Grass Carp (Ctenopharyngodon idella) via Nostril-Olfactory System-Brain Axis, Gill, and Skin on Head - PMC
PCSK9 inhibitor protects against ischemic cerebral injury by attenuating inflammation via the GPNMB/CD44 pathway
Journal
International immunopharmacology
Sublytic C5b-9 induces TIMP3 expression by glomerular mesangial cells via TRAF6-dependent KLF5 K63-linked ubiquitination in rat Thy-1 nephritis
Journal
International immunopharmacology
Hyperandrogenism drives ovarian inflammation and pyroptosis: A possible pathogenesis of PCOS follicular dysplasia
Journal
International immunopharmacology
Tamoxifen induced cardiac damage via the IL-6/p-STAT3/PGC-1 pathway
Journal
International immunopharmacology
Polypyrimidine tract binding protein knockdown reverses depression-like behaviors and cognition impairment in mice with lesioned cholinergic neurons - PMC
Journal
Frontiers in aging neuroscience
Endogenous hydrogen sulfide counteracts polystyrene nanoplastics-induced mitochondrial apoptosis and excessive autophagy via regulating Nrf2 and PGC-1α signaling pathway in mouse spermatocyte-derived GC-2spd(ts) cells
Journal
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Blockade of OX40/OX40L signaling using antiOX40L alleviates murine lupus nephritis
Journal
European journal of immunology
GCRV-II invades monocytes/macrophages and induces macrophage polarization and apoptosis in tissues to facilitate viral replication and dissemination
Journal
Journal of virology
mPEG2k-PCL x Polymeric Micelles Influence Pharmacokinetics and Hypoglycemic Efficacy of Metformin through Inhibition of Organic Cation Transporters in Rats
Helicobacter pylori East Asian type CagA hijacks more SHIP2 by its EPIYA-D motif to potentiate the oncogenicity - PMC
Buddlejasaponin Ivb Ameliorates Ferroptosis of Dopaminergic Neuron by Suppressing Irp2-Mediated Iron Overload in Parkinson's Disease
Journal
Journal of ethnopharmacology
Species
Homo sapiens, Mus musculus
The apoptotic effects of soybean agglutinin were induced through three different signal pathways by down-regulating cytoskeleton proteins in IPEC-J2 cells - PMC
Journal
Scientific reports
The Combination of Molecular Adjuvant CCL35. 2 and DNA Vaccine Significantly Enhances the Immune Protection of Carassius auratus gibelio against CyHV-2 Infection
FTR67, a member of the fish-specific finTRIM family, triggers IFN pathway and against spring viremia of carp virus
Journal
Fish & Shellfish Immunology
Identification of fish CMPK2 as an interferon stimulated gene against SVCV infection
Journal
Fish & shellfish immunology
Fish-specific finTRIM FTR36 triggers IFN pathway and mediates inhibition of viral replication.
Journal
Fish & shellfish immunology
A recombinant Mycobacterium smegmatis-based surface display system for developing the T cell-based COVID-19 vaccine
Journal
Human vaccines & immunotherapeutics
CBX7 Rejuvenates Late Passage Dental Pulp Stem Cells by Maintaining Stemness and Pro-angiogenic Ability
Journal
Tissue engineering and regenerative medicine
The role of Staphylococcus aureus small colony variants in intraosseous invasion and colonization in periprosthetic joint infection - PMC
Journal
Bone & joint research
Platelet-rich plasma activates tendon-derived stem cells to promote regeneration of Achilles tendon rupture in rats
Journal
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
Seroepidemiologic study on convalescent sera from dengue fever patients in Jinghong, Yunnan
TRIM52: A nuclear TRIM protein that positively regulates the nuclear factor-kappa B signaling pathway
Journal
Molecular immunology
ARHGEF15 in Sertoli cells contributes to germ cell development and testicular immune privilege
Journal
Biology of reproduction
Identification of stemness in primary retinoblastoma cells by analysis of stem-cell phenotypes and tumorigenicity with culture and xenograft models.
Journal
Experimental cell research
LncRNA MEG3 mediates nickel oxide nanoparticles-induced pulmonary fibrosis via suppressing TGF-β1 expression and epithelial-mesenchymal transition process
FOXA2 suppresses gallbladder carcinoma cell migration, invasion, and epithelialmesenchymal transition by targeting SERPINB5
Journal
Environmental toxicology
LncRNA HOTAIRM1 involved in Nano NiO-induced pulmonary fibrosis via regulating PRKCB DNA methylation-mediated JNK/c-Jun Pathway
Journal
Toxicological sciences : an official journal of the Society of Toxicology
Unveiling G-protein coupled receptors as potential targets for ovarian cancer nanomedicines: from RNA sequencing data analysis to in vitro validation - PMC
Journal
Journal of ovarian research
Characterization and biological function analysis of the TRIM47 gene from common carp (Cyprinus carpio)
Mitochondrial citrate accumulation triggers senescence of alveolar epithelial cells contributing to pulmonary fibrosis in mice - PMC
Mechanosensitive caveolin-1 activation-induced PI3K/Akt/mTOR signaling pathway promotes breast cancer motility, invadopodia formation and metastasis in vivo.
Species
Homo sapiens, Mus musculus
Mechanism of Arctigenin-Induced Specific Cytotoxicity against Human Hepatocellular Carcinoma Cell Lines: Hep G2 and SMMC7721
DEAD/DEAH-box helicase 5 is hijacked by an avian oncogenic herpesvirus to inhibit interferon beta production and promote viral replication
Viperin_sv1 promotes RIG-I expression and suppresses SVCV replication through its radical SAM domain
CircSND1 Regulated by TNF-α Promotes the Migration and Invasion of Cervical Cancer Cells
The construction of recombinant Lactobacillus casei expressing BVDV E2 protein and its immune response in mice
Journal
Journal of Biotechnology
Sirt1 Regulates Oxidative Stress in Oxygen-Glucose Deprived Hippocampal Neurons
Hsp90 is involved in pseudorabies virus virion assembly via stabilizing major capsid protein VP5
Production of Triple-Gene (GGTA1, B2M and CIITA)-Modified Donor Pigs for Xenotransplantation
Journal
Frontiers in veterinary science
Identification of Linear B-Cell Epitopes on Hemagglutinin Protein of Canine Distemper Virus Using Two Monoclonal Antibodies
Journal
Frontiers in Veterinary Science
Establishment of a Blocking ELISA Detection Method for Against African Swine Fever Virus p30 Antibody
Journal
Frontiers in veterinary science
Effect of SKF‑96365 on cardiomyocyte hypertrophy induced by angiotensin II
Journal
Molecular Medicine Reports
Neuropilin-1 (NRP-1)/GIPC1 pathway mediates glioma progression
DT-13 inhibits breast cancer cell migration via non-muscle myosin II-A regulation in tumor microenvironment synchronized adaptations
Journal
Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
Hypoxia-inducible factor 1/IL-6 axis in activated hepatic stellate cells aggravates liver fibrosis
Journal
Biochemical and biophysical research communications
Species
Homo sapiens, Mus musculus
The construction and immunogenicity analyses of a recombinant pseudorabies virus with porcine circovirus type 3 capsid protein co-expression
Untargeted LC-MS based metabolomic profiling of iPAMs to investigate lipid metabolic pathways alternations induced by different Pseudorabies virus strains
CD4 is an important Host Factor for Japanese Encephalitis Virus Entry and Replication in PK-15 Cells
Journal
Veterinary microbiology
Distribution, quantity and gene expression of mechanoreceptors in ligaments and tendons of knee joint in rabbits
Journal
Journal of Molecular Histology
Species
Oryctolagus cuniculus
Changes in mechanoreceptors in rabbits' anterior cruciate ligaments with age.
Journal
Journal of molecular histology
Species
Oryctolagus cuniculus
Chronic Electroacupuncture With High-Frequency at ST-36 Promotes Gastrointestinal Motility by Regulating Bone Morphogenetic Protein 2 Secretion of Muscularis
Journal
Neuromodulation : journal of the International Neuromodulation Society
Extract of bulbus of Fritillaria cirrhosa induces spindle multipolarity in human-derived colonic epithelial NCM460 cells through promoting centrosome fragmentation
CgPHB2 involved in the haemocyte mitophagy in response to Vibrio splendidus stimulation in Pacific oyster Crassostrea gigas
Journal
Developmental and comparative immunology
MicroRNA-122 inhibits epithelial-mesenchymal transition of hepatic stellate cells induced by the TGF-β1/Smad signaling pathway.
Journal
Experimental and Therapeutic Medicine
Investigating molecular markers linked to acute myocardial infarction and cuproptosis: bioinformatics analysis and validation in the AMI mice model - PMC
Replacing the decoy epitope of PCV2 capsid protein with epitopes of GP3 and/or GP5 of PRRSV enhances the immunogenicity of bivalent vaccines in mice
Pirfenidone inhibits TGF-1-induced fibrosis via downregulation of Smad and ERK pathway in MDCK cells
Journal
Veterinary research communications
Herpes Simplex Virus 1-Induced Ferroptosis Contributes to Viral Encephalitis
Protocol to generate induced trophoblast stem cells from embryonic stem cells in mice - PMC