Multi-omics analyses of 398 foxtail millet accessions reveal genomic regions associated with domestication, metabolite traits, and anti-inflammatory effects
Adipocyte IRE1α promotes PGC1α mRNA decay and restrains adaptive thermogenesis
Pulmonary Surfactant Homeostasis Dysfunction Mediates Multiwalled Carbon Nanotubes Induced Lung Fibrosis via Elevating Surface Tension
miR-210 participates in hepatic ischemia reperfusion injury by forming a negative feedback loop with SMAD4
Journal
Hepatology (Baltimore, Md.)
Sphingosine d18:1 promotes nonalcoholic steatohepatitis by inhibiting macrophage HIF-2 - PMC
Journal
Nature communications
PhaseChange Based Oxygen Carriers Improve Acute Cerebral Hypoxia
Journal
Small (Weinheim an der Bergstrasse, Germany)
Cytoplasmic Escape of Mitochondrial DNA Mediated by Mfn2 Downregulation Promotes Microglial Activation via cGasSting Axis in Spinal Cord Injury
Stromal BMP signaling regulates mucin production in the large intestine via interleukin-1/17 - PMC
A transcription‐independent mechanism determines rapid periodic fluctuations of BRCA1 expression
The involvement of SigmaR1K142 degradation mediated by ERAD in neural senescence linked with CdCl2 exposure
Journal
Journal of hazardous materials
Pristimerin suppresses AIM2 inflammasome by modulating AIM2-PYCARD/ASC stability via selective autophagy to alleviate tendinopathy
ALDOA maintains NLRP3 inflammasome activation by controlling AMPK activation
ROS-responsive microneedles loaded with integrin avβ6-blocking antibodies for the treatment of pulmonary fibrosis
Journal
Journal of controlled release : official journal of the Controlled Release Society
TrxR1 is involved in the activation of Caspase-11 by regulating the oxidative-reductive status of Trx-1 - PMC
Forsythoside A Mitigates Alzheimer's-like Pathology by Inhibiting Ferroptosis-mediated Neuroinflammation via Nrf2/GPX4 Axis Activation
Journal
International journal of biological sciences
Multifunctional annulus fibrosus matrix prevents disc-related pain via inhibiting neuroinflammation and sensitization
Journal
Acta biomaterialia
Combined treatment of xyloglucan derivative hydrogel and anti-C5a receptor antibody in preventing peritoneal adhesion
Journal
Acta biomaterialia
Platelet 3D Preservation Using a Novel Biomimetic Nanofiber Peptide for Reduced Apoptosis and Easy Storage
Journal
ACS Appl Mater Interfaces
Self-Assembly of Antimicrobial Peptide-Based Micelles Breaks the Limitation of Trypsin
Journal
ACS applied materials & interfaces
Purinergic Receptor P2 7 Contributes to Abdominal Aortic Aneurysm Development via Modulating Macrophage Pyroptosis and Inflammation
Journal
Translational research : the journal of laboratory and clinical medicine
A Missense Mutation in Lectin Domain of Thrombomodulin Causing Functional Deficiency
Journal
Translational research : the journal of laboratory and clinical medicine
Oroxylin A maintains the colonic mucus barrier to reduce disease susceptibility by reconstituting a dietary fiber-deprived gut microbiota
Fluoxetine regulates eEF2 activity (phosphorylation) via HDAC1 inhibitory mechanism in an LPS-induced mouse model of depression
Journal
J Neuroinflammation
NOD-like receptor NLRC5 promotes neuroinflammation and inhibits neuronal survival in Parkinsons disease models - PMC
Journal
Journal of neuroinflammation
Functional interplay between liver X receptor and AMP-activated protein kinase inhibits atherosclerosis in apolipoprotein E-deficient mice - a new anti-atherogenic strategy.
Journal
British Journal of Pharmacology
Hypoxia inducible factor-1 regulates microglial innate immune memory and the pathology of Parkinson's disease
Journal
Journal of neuroinflammation
Colchicine Blocks Abdominal Aortic Aneurysm Development by Maintaining Vascular Smooth Muscle Cell Homeostasis - PMC
Journal
International journal of biological sciences
Hspb1 protects against severe acute pancreatitis by attenuating apoptosis and ferroptosis via interacting with Anxa2 to restore the antioxidative activity of
Journal
International journal of biological sciences
Interferon Regulatory Factor 5 Mediates Lipopolysaccharide Induced Neuroinflammation
Platelet-Derived Exosomal MicroRNA-25-3p Inhibits Coronary Vascular Endothelial Cell Inflammation Through Adam10 via the NF-κB Signaling Pathway in ApoE -/- Mice.
Journal
Frontiers in Immunology
KW2449 ameliorates collagen-induced arthritis by inhibiting RIPK1-dependent necroptosis - PMC
Journal
Frontiers in immunology
Connexin32 gap junction channels deliver miR155-3p to mediate pyroptosis in renal ischemia-reperfusion injury - PMC
Journal
Cell communication and signaling : CCS
Targeting hepatic ceruloplasmin mitigates nonalcoholic steatohepatitis by modulating bile acid metabolism
Journal
Journal of molecular cell biology
sFgl2 gene-modified MSCs regulate the differentiation of CD4+ T cells in the treatment of autoimmune hepatitis - PMC
Journal
Stem cell research & therapy
Quinoa bran soluble dietary fiber ameliorates dextran sodium sulfate induced ulcerative colitis in BALB/c mice by maintaining intestinal barrier function and
Journal
International journal of biological macromolecules
Structure characterization and immunomodulatory activity of a polysaccharide from Saposhnikoviae Radix
Journal
International journal of biological macromolecules
Abrocitinib Attenuates Microglia-Mediated Neuroinflammation after Traumatic Brain Injury via Inhibiting the JAK1/STAT1/NF-κB Pathway - PMC
Transplantation of the LRP1high subpopulation of human umbilical cord-derived mesenchymal stem cells improves ovarian function in mice with premature ovarian failure and aged mice - PMC
Journal
Stem cell research & therapy
Danthron ameliorates obesity and MAFLD through activating the interplay between PPARα/RXRα heterodimer and adiponectin receptor 2
Journal
Biomed Pharmacother
Ginsenoside Rg1 ameliorates hypoxia-induced pulmonary arterial hypertension by inhibiting endothelial-to-mesenchymal transition and inflammation by
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Histone hyperacetylation mediates enhanced IL-1β production in LPS/IFN-γ-stimulated macrophages
Differences in the characteristics and pulmonary toxicity of nano- and micron-sized respirable coal dust - PMC
Journal
Respiratory research
Species
Homo sapiens, Mus musculus
Hesperetin derivative 2a inhibits lipopolysaccharide-induced acute liver injury in mice via downregulation of circDcbld2
Journal
Acta pharmacologica Sinica
Disulfiram attenuates hypoxia-induced pulmonary hypertension by inhibiting GSDMD cleavage and pyroptosis in HPASMCs - PMC
Journal
Respiratory research
Multi-omics analysis reveals BDE47 induces depression-like behaviors in mice by interfering with the 2-arachidonoyl glycerol-associated microbiota-gut-brain
Journal
Ecotoxicology and environmental safety
Progesterone Receptor Membrane Component 1 Regulates Cellular Stress Responses and Inflammatory Pathways in Chronic Neuroinflammatory Conditions - PMC
Journal
Antioxidants (Basel, Switzerland)
The Neuroprotection of Verbascoside in Alzheimer's Disease Mediated through Mitigation of Neuroinflammation via Blocking NF-B-p65 Signaling
Species
Homo sapiens, Mus musculus
Structural modification based on the diclofenac scaffold: Achieving reduced colitis side effects through COX-2/NLRP3 selective inhibition
Journal
European journal of medicinal chemistry
Echinacoside Exerts Neuroprotection via Suppressing Microglial -synuclein/TLR2/NF-B/NLRP3 Axis in Parkinsonian Models
Journal
Phytomedicine : international journal of phytotherapy and phytopharmacology
Geniposide alleviated bile acid-associated NLRP3 inflammasome activation by regulating SIRT1/FXR signaling in bile duct ligation-induced liver fibrosis
Journal
Phytomedicine : international journal of phytotherapy and phytopharmacology
Xuanfei Baidu Decoction suppresses complement overactivation and ameliorates IgG immune complex-induced acute lung injury by inhibiting JAK2/STAT3/SOCS3 and NF-κB signaling pathway - PMC
Journal
Phytomedicine : international journal of phytotherapy and phytopharmacology
Anti-Inflammatory Effect of a Polyphenol-Enriched Fraction from Acalypha wilkesiana on Lipopolysaccharide-Stimulated RAW 264.7 Macrophages and Acetaminophen-Induced Liver Injury in Mice.
Journal
Oxidative Medicine and Cellular Longevity
Sulforaphene Ameliorates Neuroinflammation and Hyperphosphorylated Tau Protein via Regulating the PI3K/Akt/GSK-3β Pathway in Experimental Models of Alzheimer's Disease
Journal
Oxid Med Cell Longev
The Protective Effects of Imperatorin on Acetaminophen Overdose-Induced Acute Liver Injury
Journal
Oxidative Medicine and Cellular Longevity
Pseudorabies Virus Infection Activates the TLR-NF-B Axis and AIM2 Inflammasome To Enhance Inflammatory Responses in Mice
Journal
Journal of virology
Species
Homo sapiens, Mus musculus
H 2 S-mediated aerobic exercise antagonizes the hippocampal inflammatory response in CUMS-depressed mice
AdipoRon Inhibits Neuroinflammation Induced by Deep Hypothermic Circulatory Arrest Involving the AMPK/NF-κB Pathway in Rats - PMC
Narirutin exerts anti‐inflammatory activity by inhibiting NLRP3 inflammasome activation in macrophages
Journal
Phytotherapy research : PTR
Melatonin Act as an Antidepressant via Attenuation of Neuroinflammation by Targeting Sirt1/Nrf2/HO-1 Signaling
Journal
Frontiers in molecular neuroscience
Ameliorating Effects of Vitamin K2 on Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice - PMC
Journal
International journal of molecular sciences
Swimming exercise alleviates pathological bone features in curdlan-injected SKG mice by inducing irisin expression
Adipose-Derived Mesenchymal Stem Cells Ameliorating Pseudomonas aeruginosa-induced Acute Lung Infection via Inhibition of NLRC4 Inflammasome
Journal
Front Cell Infect Microbiol
Cangma Huadu granules attenuate H1N1 virus-induced severe lung injury correlated with repressed apoptosis and altered gut microbiome - PMC
Journal
Frontiers in microbiology
Cangma Huadu granules attenuate H1N1 virus-induced severe lung injury correlated with repressed apoptosis and altered gut microbiome - PMC
Journal
Frontiers in microbiology
Qiangji Decoction Alleviates Neurodegenerative Changes and Hippocampal Neuron Apoptosis Induced by D-Galactose via Regulating AMPK/SIRT1/NF-κB Signaling Pathway
Sesamin ameliorates nonalcoholic steatohepatitis through inhibiting hepatocyte pyroptosis in vivo and in vitro
- PMC
Journal
Frontiers in pharmacology
Naringenin protects against acute pancreatitis-associated intestinal injury by inhibiting NLRP3 inflammasome activation via AhR signaling - PMC
Journal
Frontiers in pharmacology
Ginsenoside Rc attenuates DSS-induced ulcerative colitis, intestinal inflammatory, and barrier function by activating the farnesoid X receptor - PMC
Journal
Frontiers in pharmacology
TRAF3 promotes ROS production and pyroptosis by targeting ULK1 ubiquitination in macrophages
Journal
FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
BMAL1 plays a crucial role in immune homeostasis during sepsis-induced acute lung injury
Journal
Biochemical pharmacology
Isodeoxyelephantopin, a sesquiterpene lactone from Elephantopus scaber Linn., inhibits pro-inflammatory mediators' production through both NF-κB and AP-1 pathways in LPS-activated macrophages
Journal
International Immunopharmacology
The selective NLRP3-inflammasome inhibitor MCC950 reduces myocardial fibrosis and improves cardiac remodeling in a mouse model of myocardial infarction.
Journal
International immunopharmacology
Mesenchymal stem cells attenuate systemic lupus erythematosus by inhibiting NLRP3 inflammasome activation through Pim-1 kinase
Journal
International immunopharmacology
HDL inhibits pancreatic acinar cell NLRP3 inflammasome activation and protect against acinar cell pyroptosis in acute pancreatitis
Journal
International immunopharmacology
4-octyl itaconate ameliorates alveolar macrophage pyroptosis against ARDS via rescuing mitochondrial dysfunction and suppressing the cGAS/STING pathway
Journal
International immunopharmacology
Aerobic exercise combined with chlorogenic acid exerts neuroprotective effects and reverses cognitive decline in Alzheimers disease model mice (APP/PS1) via the SIRT1/ /PGC-1/PPAR signaling pathway - PMC
Journal
Frontiers in aging neuroscience
Downregulation of the (pro) renin receptor alleviates ferroptosis-associated cardiac pathological changes via the NCOA 4-mediated ferritinophagy pathway in diabetic
Journal
International immunopharmacology
Protective effect of Timosaponin AIII on Escherichia coli-induced endometritis in mice through inhibiting inflammatory response and regulating uterine microbiota
Journal
International immunopharmacology
GTS-21 attenuates ACE/ACE2 ratio and glycocalyx shedding in lipopolysaccharide-induced acute lung injury by targeting macrophage polarization derived
Journal
International immunopharmacology
The ER stress sensor inositol-requiring enzyme 1α in Kupffer cells promotes hepatic ischemia-reperfusion injury
A virulent Bacillus cereus strain from deep-sea cold seep induces pyroptosis in a manner that involves NLRP3 inflammasome, JNK pathway, and lysosomal rupture
Species
Scophthalmus maximus
Safranal alleviates pentetrazole-induced epileptic seizures in mice by inhibiting the NF-B signaling pathway and mitochondrial-dependent apoptosis through GSK-3
Journal
Journal of ethnopharmacology
Serum Metabolome Mediates the Antiobesity Effect of Celastrol-Induced Gut Microbial Alterations
Margatoxin mitigates CCl4-induced hepatic fibrosis in mice via macrophage polarization, cytokine secretion and STAT signaling.
Journal
International Journal of Molecular Medicine
Ethanol extract of Elephantopus scaber Linn. Attenuates inflammatory response via the inhibition of NF-κB signaling by dampening p65-DNA binding activity in lipopolysaccharide-activated macrophages
Journal
Journal of Ethnopharmacology
Huang-Lian-Jie-Du decoction drug-containing serum inhibits IL-1 secretion from D-glucose and PA induced BV2 cells via autophagy/NLRP3 signaling
Journal
Journal of ethnopharmacology
Hippocampal GPR35 Participates in the Pathogenesis of Cognitive Deficits and Emotional Alterations Induced by A142 in Mice
Journal
Molecular neurobiology
Interferon Regulatory Factor 5 Regulates the Phagocytosis of Microglia and Alleviate Alzheimer's Pathology
Journal
The journals of gerontology. Series A, Biological sciences and medical sciences
Ethanol Extract of Rosa laevigata Michx. Fruit Inhibits Inflammatory Responses through NF-B/MAPK Signaling Pathways via AMPK Activation in RAW 264.7 Macrophages - PMC
Journal
Molecules (Basel, Switzerland)
Steroidal Alkaloids from the Roots of Veratrum mengtzeanum Loes. with Their Anti-Inflammatory Activities - PMC
Journal
Molecules (Basel, Switzerland)
LanGui tea, an herbal medicine formula, protects against binge alcohol-induced acute liver injury by activating AMPK-NLRP3 signaling - PMC
The Protective Effects of Imperatorin on Acetaminophen Overdose-Induced Acute Liver Injury.
Journal
Oxidative Medicine and Cellular Longevity
Parabacteroides distasonis-Derived Outer Membrane Vesicles Enhance Antitumor Immunity Against Colon Tumors by Modulating CXCL10 and CD8+ T Cells - PMC
Journal
Drug design, development and therapy
Synthesis and Anti-Inflammatory Activity of the Natural Cyclooxygenase-2 Inhibitor Axinelline A and Its Analogues
Journal
Journal of natural products
Extract of Corallodiscus flabellata attenuates renal fibrosis in SAMP8 mice via the Wnt/-catenin/RAS signaling pathway
Journal
BMC complementary medicine and therapies
Species
Homo sapiens, Mus musculus
Curcumae radix Reduces Endoplasmic Reticulum Stress in Mice with Chronic Neuroinflammation - PMC
Puerarin Protects Against LPS-Induced Vascular Endothelial Cell Hyperpermeability via Preventing Downregulation of Endothelial Cadherin.
Transcription elements AREB6 and miR-34a affect apoptosis of PAMs by regulating the expression of SS2-related gene PPP1R11.
Dynamic evaluation of pathological changes in a mouse acne model by optical imaging technology
Journal
Experimental dermatology
Xanthohumol Attenuates Lipopolysaccharide-Induced Depressive Like Behavior in Mice: Involvement of NF-κB/Nrf2 Signaling Pathways
Journal
Neurochemical research
Role of the Omentin-1 in Susceptibility to Anxiety and Depression Like Behaviors
Journal
Molecular and cellular endocrinology
Low-dose Cu exposure enhanced -synuclein accumulation associates with mitochondrial impairments in mice model of Parkinson's disease
Journal
Toxicology letters
Involvement of RhoA/ROCK Signaling in Aβ-Induced Chemotaxis, Cytotoxicity and Inflammatory Response of Microglial BV2 Cells.
Journal
Cellular and molecular neurobiology
Electroacupuncture at ST-36 ameliorates DSS-induced acute colitis via regulating macrophage polarization induced by suppressing NLRP3/IL-1 and promoting Nrf2/HO-1.
Journal
Molecular immunology
Alipoic acid alleviates DSSinduced ulcerative colitis via modulating Keap1Nrf2 signaling pathway and inhibiting ferroptosis
Journal
Journal of the science of food and agriculture
The effect and mechanism of Huangqin-Baishao herb pair in the treatment of dextran sulfate sodium-induced ulcerative colitis - PMC
The protective effect of 999 XiaoErGanMao granules on the lungs and intestines of influenza A virus-infected mice - PMC
Journal
Pharmaceutical biology
Staphylococcus aureus mediates pyroptosis in bovine mammary epithelial cell via activation of NLRP3 inflammasome
Journal
Veterinary research
Inhibition of SIRT6 aggravates p53-mediated ferroptosis in acute lung injury in mice - PMC
Benzene, 1, 2, 4-trimethoxy-5-(2-methyl-1-propen-1-yl) Attenuates D-galactose/AlCl3-induced Cognitive Impairment by Inhibiting Inflammation, Apoptosis, and
Design of novel balanced COX inhibitors based on natural antiinflammatory ascidian metabolites and celecoxib
Monomethyl fumarate prevents alloimmune rejection in mouse heart transplantation by inducing tolerogenic dendritic cells - PMC
Journal
Acta biochimica et biophysica Sinica
Aerobic Exercise Inhibits CUMS-Depressed Mice Hippocampal Inflammatory Response via Activating Hippocampal miR-223/TLR4/MyD88-NF-B Pathway.
Journal
International Journal of Environmental Research and Public Health
Dopamine D1 receptor alleviates doxorubicin-induced cardiac injury by inhibiting NLRP3 inflammasome
Journal
Biochem Biophys Res Commun
Bufalin reduces myocardial infarction‐induced myocardial fibrosis and improves cardiac function by inhibiting the NLRP3/IL‐1β signalling pathway
Journal
Clinical and experimental pharmacology & physiology
In vitro and in silico analysis of ‘Taikong blue lavender essential oil in LPS-induced HaCaT cells and RAW264.7 murine macrophages - PMC
Journal
BMC complementary medicine and therapies
In vitro and in silico analysis of ‘Taikong blue lavender essential oil in LPS-induced HaCaT cells and RAW264.7 murine macrophages - PMC
Journal
BMC complementary medicine and therapies
Therapeutic effect of a self-made herbal formula on a multi-drug resistant Eimeria tenella isolate infection in broiler chickens
Journal
Veterinary parasitology
Gualou Guizhi Granule Suppresses LPS-Induced Inflammatory Response of Microglia and Protects against Microglia-Mediated Neurotoxicity in HT-22 via Akt/NF-κB Signaling Pathways
Journal
Evid Based Complement Alternat Med
Naringenin ameliorates collagen-induced arthritis through activating AMPK-mediated autophagy in macrophages - PMC
Journal
Immunity, inflammation and disease
Prophylactic supplementation with Bifidobacterium infantis or its metabolite inosine attenuates cardiac ischemia/reperfusion injury - PMC
Nucleoside-diphosphate kinase of uropathogenic Escherichia coli inhibits caspase-1-dependent pyroptosis facilitating urinary tract infection
Caffeic acid, but not ferulic acid, inhibits macrophage pyroptosis by directly blocking gasdermin D activation - PMC