Elimination of methicillin-resistant Staphylococcus aureus biofilms on titanium implants via photothermally-triggered nitric oxide and immunotherapy for enhanced osseointegration - PMC
Journal
Military Medical Research
Multi-omics analyses of 398 foxtail millet accessions reveal genomic regions associated with domestication, metabolite traits, and anti-inflammatory effects
Pulmonary Surfactant Homeostasis Dysfunction Mediates Multiwalled Carbon Nanotubes Induced Lung Fibrosis via Elevating Surface Tension
Attenuating Uncontrolled Inflammation by Radical Trapping Chiral Polymer Micelles
Glucocorticoids increase adiposity by stimulating Krüppel-like factor 9 expression in macrophages - PMC
Journal
Nature communications
An ischemic area-targeting, peroxynitrite-responsive, biomimetic carbon monoxide nanogenerator for preventing myocardial ischemia-reperfusion injury - PMC
Journal
Bioactive materials
Inflammatory FibroblastLike SynoviocyteDerived Exosomes Aggravate Osteoarthritis via Enhancing Macrophage Glycolysis
Journal
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Biomimetic "gemini nanoimmunoregulators" orchestrated for boosted photoimmunotherapy by spatiotemporally modulating PD-L1 and tumor-associated
Journal
Acta pharmaceutica Sinica. B
A transcription‐independent mechanism determines rapid periodic fluctuations of BRCA1 expression
Melatonin prevents neuroinflammation and relieves depression by attenuating autophagy impairment through FOXO3a regulation
Journal
Journal of Pineal Research
TRAF3/STAT6 axis regulates macrophage polarization and tumor progression
Journal
Cell death and differentiation
ROS-responsive microneedles loaded with integrin avβ6-blocking antibodies for the treatment of pulmonary fibrosis
Journal
Journal of controlled release : official journal of the Controlled Release Society
Forsythoside A Mitigates Alzheimer's-like Pathology by Inhibiting Ferroptosis-mediated Neuroinflammation via Nrf2/GPX4 Axis Activation
Journal
International journal of biological sciences
Multifunctional annulus fibrosus matrix prevents disc-related pain via inhibiting neuroinflammation and sensitization
Journal
Acta biomaterialia
Combined treatment of xyloglucan derivative hydrogel and anti-C5a receptor antibody in preventing peritoneal adhesion
Journal
Acta biomaterialia
Platelet 3D Preservation Using a Novel Biomimetic Nanofiber Peptide for Reduced Apoptosis and Easy Storage
Journal
ACS Appl Mater Interfaces
Self-Assembly of Antimicrobial Peptide-Based Micelles Breaks the Limitation of Trypsin
Journal
ACS applied materials & interfaces
A Missense Mutation in Lectin Domain of Thrombomodulin Causing Functional Deficiency
Journal
Translational research : the journal of laboratory and clinical medicine
Development of a dual-functional conjugate of antigenic peptide and Fc-III mimetics (DCAF) for targeted antibody blocking.
Fluoxetine regulates eEF2 activity (phosphorylation) via HDAC1 inhibitory mechanism in an LPS-induced mouse model of depression
Journal
J Neuroinflammation
Knockdown and inhibition of hippocampal GPR17 attenuates lipopolysaccharide-induced cognitive impairment in mice - PMC
Journal
Journal of neuroinflammation
Nel-like Molecule Type 1 Combined with Gold Nanoparticles Modulates Macrophage Polarization, Osteoclastogenesis, and Oral Microbiota in Periodontitis
Journal
ACS applied materials & interfaces
Functional interplay between liver X receptor and AMP-activated protein kinase inhibits atherosclerosis in apolipoprotein E-deficient mice - a new anti-atherogenic strategy.
Journal
British Journal of Pharmacology
Colchicine Blocks Abdominal Aortic Aneurysm Development by Maintaining Vascular Smooth Muscle Cell Homeostasis - PMC
Journal
International journal of biological sciences
Malat1 regulates PMN-MDSC expansion and immunosuppression through p-STAT3 ubiquitination in sepsis - PMC
Journal
International journal of biological sciences
Hspb1 protects against severe acute pancreatitis by attenuating apoptosis and ferroptosis via interacting with Anxa2 to restore the antioxidative activity of
Journal
International journal of biological sciences
Therapeutic potency of compound RMY-205 for pulmonary fibrosis induced by SARS-CoV-2 nucleocapsid protein - PMC
Journal
Cell chemical biology
Interferon Regulatory Factor 5 Mediates Lipopolysaccharide Induced Neuroinflammation
Platelet-Derived Exosomal MicroRNA-25-3p Inhibits Coronary Vascular Endothelial Cell Inflammation Through Adam10 via the NF-κB Signaling Pathway in ApoE -/- Mice.
Journal
Frontiers in Immunology
Lab-Attenuated Rabies Virus Causes Abortive Infection and Induces Cytokine Expression in Astrocytes by Activating Mitochondrial Antiviral-Signaling Protein Signaling Pathway.
Journal
Frontiers in Immunology
KW2449 ameliorates collagen-induced arthritis by inhibiting RIPK1-dependent necroptosis - PMC
Journal
Frontiers in immunology
Structural characterization and immunomodulatory activity of a polysaccharide from Dioscotea opposita
Journal
International journal of biological macromolecules
sFgl2 gene-modified MSCs regulate the differentiation of CD4+ T cells in the treatment of autoimmune hepatitis - PMC
Journal
Stem cell research & therapy
Structure characterization and immunomodulatory activity of a polysaccharide from Saposhnikoviae Radix
Journal
International journal of biological macromolecules
Abrocitinib Attenuates Microglia-Mediated Neuroinflammation after Traumatic Brain Injury via Inhibiting the JAK1/STAT1/NF-κB Pathway - PMC
Combined transplantation of hiPSC-NSC and hMSC ameliorated neuroinflammation and promoted neuroregeneration in acute spinal cord injury - PMC
Journal
Stem cell research & therapy
Amelioration of diabetic nephropathy in mice by a single intravenous injection of human mesenchymal stromal cells at early and later disease stages is associated with restoration of autophagy - PMC
Journal
Stem cell research & therapy
Danthron ameliorates obesity and MAFLD through activating the interplay between PPARα/RXRα heterodimer and adiponectin receptor 2
Journal
Biomed Pharmacother
Berberine exerts antidepressant effects in vivo and in vitro through the PI3K/AKT/CREB/BDNF signaling pathway
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
STING/NF-B/IL-6-Mediated Inflammation in Microglia Contributes to Spared Nerve Injury (SNI)-Induced Pain Initiation
Journal
J Neuroimmune Pharmacol
Differences in the characteristics and pulmonary toxicity of nano- and micron-sized respirable coal dust - PMC
Journal
Respiratory research
Species
Homo sapiens, Mus musculus
Multi-omics analysis reveals BDE47 induces depression-like behaviors in mice by interfering with the 2-arachidonoyl glycerol-associated microbiota-gut-brain
Journal
Ecotoxicology and environmental safety
Identification of Pyrido [3, 4-D] Pyrimidine Derivatives as Ripk3-Mediated Necroptosis Inhibitors
Journal
European journal of medicinal chemistry
Nicotine suppresses crystalline silicainduced astrocyte activation and neuronal death by inhibiting NFB in the mouse hippocampus
Journal
CNS neuroscience & therapeutics
Nicotine suppresses crystalline silicainduced astrocyte activation and neuronal death by inhibiting NFB in the mouse hippocampus
Journal
CNS neuroscience & therapeutics
Nicotine suppresses crystalline silicainduced astrocyte activation and neuronal death by inhibiting NFB in the mouse hippocampus
Journal
CNS neuroscience & therapeutics
Mitigation of Sepsis-Induced Acute Lung Injury by BMSC-Derived Exosomal miR-125b-5p Through STAT3-Mediated Suppression of Macrophage Pyroptosis - PMC
Journal
International journal of nanomedicine
Taurohyodeoxycholic acid alleviates trinitrobenzene sulfonic acid induced ulcerative colitis via regulating Th1/Th2 and Th17/Treg cells balance
Interleukin-9 attenuates inflammatory response and hepatocyte apoptosis in alcoholic liver injury
Chronic intermittent hypobaric hypoxia attenuates skeletal muscle ischemia-reperfusion injury in mice
The Neuroprotection of Verbascoside in Alzheimer's Disease Mediated through Mitigation of Neuroinflammation via Blocking NF-B-p65 Signaling
Species
Homo sapiens, Mus musculus
Sesamol Alleviates Obesity-Related Hepatic Steatosis via Activating Hepatic PKA Pathway
Structural modification based on the diclofenac scaffold: Achieving reduced colitis side effects through COX-2/NLRP3 selective inhibition
Journal
European journal of medicinal chemistry
Echinacoside Exerts Neuroprotection via Suppressing Microglial -synuclein/TLR2/NF-B/NLRP3 Axis in Parkinsonian Models
Journal
Phytomedicine : international journal of phytotherapy and phytopharmacology
Xuanfei Baidu Decoction suppresses complement overactivation and ameliorates IgG immune complex-induced acute lung injury by inhibiting JAK2/STAT3/SOCS3 and NF-κB signaling pathway - PMC
Journal
Phytomedicine : international journal of phytotherapy and phytopharmacology
Anti-Inflammatory Effect of a Polyphenol-Enriched Fraction from Acalypha wilkesiana on Lipopolysaccharide-Stimulated RAW 264.7 Macrophages and Acetaminophen-Induced Liver Injury in Mice.
Journal
Oxidative Medicine and Cellular Longevity
Sulforaphene Ameliorates Neuroinflammation and Hyperphosphorylated Tau Protein via Regulating the PI3K/Akt/GSK-3β Pathway in Experimental Models of Alzheimer's Disease
Journal
Oxid Med Cell Longev
The Protective Effects of Imperatorin on Acetaminophen Overdose-Induced Acute Liver Injury
Journal
Oxidative Medicine and Cellular Longevity
Pseudorabies Virus Infection Activates the TLR-NF-B Axis and AIM2 Inflammasome To Enhance Inflammatory Responses in Mice
Journal
Journal of virology
Species
Homo sapiens, Mus musculus
AdipoRon Inhibits Neuroinflammation Induced by Deep Hypothermic Circulatory Arrest Involving the AMPK/NF-κB Pathway in Rats - PMC
Narirutin exerts anti‐inflammatory activity by inhibiting NLRP3 inflammasome activation in macrophages
Journal
Phytotherapy research : PTR
The effect and mechanism of Jiao-tai-wan in the treatment of diabetes mellitus with depression based on network pharmacology and experimental analysis
Lycopene ameliorates islet function and down-regulates TLR4/MyD88/NF-B pathway in diabetic mice and Min6 cells
Melatonin Act as an Antidepressant via Attenuation of Neuroinflammation by Targeting Sirt1/Nrf2/HO-1 Signaling
Journal
Frontiers in molecular neuroscience
The Role of Hyperthermia in Methamphetamine-Induced Depression-Like Behaviors: Protective Effects of Coral Calcium Hydride
Journal
Frontiers in molecular neuroscience
Regulation of Gut Microflora by Lactobacillus casei Zhang Attenuates Liver Injury in Mice Caused by Anti-Tuberculosis Drugs - PMC
Journal
International journal of molecular sciences
Ameliorating Effects of Vitamin K2 on Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice - PMC
Journal
International journal of molecular sciences
Combined biological effects and lung proteomics analysis in mice reveal different toxic impacts of electronic cigarette aerosol and combustible cigarette smoke on the respiratory system - PMC
Journal
Archives of toxicology
Exploration of the mechanism of Qi-Xian decoction in asthmatic mice using metabolomics combined with network pharmacology - PMC
Journal
Frontiers in molecular biosciences
Swimming exercise alleviates pathological bone features in curdlan-injected SKG mice by inducing irisin expression
Folic Acid Attenuates High-Fat Diet-Induced Osteoporosis Through the AMPK Signaling Pathway
Journal
Frontiers in cell and developmental biology
Rifaximin Alters Intestinal Microbiota and Prevents Progression of Ankylosing Spondylitis in Mice.
Journal
Frontiers in Cellular and Infection Microbiology
Loaded delta-hemolysin shapes the properties of Staphylococcus aureus membrane vesicles - PMC
Journal
Frontiers in microbiology
Overexpression of miR-146a Might Regulate Polarization Transitions of BV-2 Cells Induced by High Glucose and Glucose Fluctuations.
Journal
Frontiers in Endocrinology
Ginsenoside Rb1 Ameliorates Age-Related Myocardial Dysfunction by Regulating the NF-κ B Signaling Pathway
Qiangji Decoction Alleviates Neurodegenerative Changes and Hippocampal Neuron Apoptosis Induced by D-Galactose via Regulating AMPK/SIRT1/NF-κB Signaling Pathway
Emodin ameliorates renal injury and fibrosis via regulating the miR-490-3p/HMGA2 axis - PMC
Journal
Frontiers in pharmacology
Naringenin protects against acute pancreatitis-associated intestinal injury by inhibiting NLRP3 inflammasome activation via AhR signaling - PMC
Journal
Frontiers in pharmacology
Ginsenoside Rc attenuates DSS-induced ulcerative colitis, intestinal inflammatory, and barrier function by activating the farnesoid X receptor - PMC
Journal
Frontiers in pharmacology
Inhibition of fucosylation by 2-fluorofucose attenuated acetaminophen-induced liver injury via its anti-inflammation and anti-oxidative stress effects - PMC
Journal
Frontiers in pharmacology
Theabrownin and Poria cocos Polysaccharide Improve Lipid Metabolism via Modulation of Bile Acid and Fatty Acid Metabolism - PMC
Journal
Frontiers in pharmacology
Rosiglitazone retards the progression of iron overload-induced osteoarthritis by impeding chondrocyte ferroptosis - PMC
LGK974 suppresses the formation of deep vein thrombosis in mice with sepsis
Journal
International immunopharmacology
Koumine ameliorates concanavalin A-induced autoimmune hepatitis in mice: involvement of the Nrf2, NF-κB pathways, and gut microbiota
Journal
International immunopharmacology
Aerobic exercise combined with chlorogenic acid exerts neuroprotective effects and reverses cognitive decline in Alzheimers disease model mice (APP/PS1) via the SIRT1/ /PGC-1/PPAR signaling pathway - PMC
Journal
Frontiers in aging neuroscience
Protective effect of Timosaponin AIII on Escherichia coli-induced endometritis in mice through inhibiting inflammatory response and regulating uterine microbiota
Journal
International immunopharmacology
GTS-21 attenuates ACE/ACE2 ratio and glycocalyx shedding in lipopolysaccharide-induced acute lung injury by targeting macrophage polarization derived
Journal
International immunopharmacology
STING/TBK1 Regulates Inflammation in Macrophages and Titanium Particles-Induced Osteolysis
Journal
ACS biomaterials science & engineering
Serum Metabolome Mediates the Antiobesity Effect of Celastrol-Induced Gut Microbial Alterations
Margatoxin mitigates CCl4-induced hepatic fibrosis in mice via macrophage polarization, cytokine secretion and STAT signaling.
Journal
International Journal of Molecular Medicine
Margatoxin mitigates CCl4-induced hepatic fibrosis in mice via macrophage polarization, cytokine secretion and STAT signaling.
Journal
International Journal of Molecular Medicine
Repair function of essential oil from Crocodylus Siamensis (Schneider, 1801) on the burn wound healing via up-regulated growth factor expression and anti-inflammatory effect
Integrative serum metabolomics and network analysis on mechanisms exploration of Ling-Gui-Zhu-Gan Decoction on doxorubicin-induced heart failure mice
Journal
Journal of Ethnopharmacology
Phthalides from the rhizome of Ligusticum chuanxiong Hort. attenuate diabetic nephropathy in mice
Journal
Journal of ethnopharmacology
Neuroprotective effects of PRG on Aβ25-35-induced cytotoxicity through activation of the ERK1/2 signaling pathway
Journal
Journal of ethnopharmacology
Reversing Tumor Immunosuppressive Microenvironment via Targeting Codelivery of CpG ODNs/PD-L1 Peptide Antagonists to Enhance the Immune Checkpoint blockade-based anti-tumor effect
Hippocampal GPR35 Participates in the Pathogenesis of Cognitive Deficits and Emotional Alterations Induced by A142 in Mice
Journal
Molecular neurobiology
Interferon Regulatory Factor 5 Regulates the Phagocytosis of Microglia and Alleviate Alzheimer's Pathology
Journal
The journals of gerontology. Series A, Biological sciences and medical sciences
Osteoblastic protein kinase D1 contributes to the prostate cancer cells dormancy via GAS6-circadian clock signaling
Journal
Biochimica et biophysica acta. Molecular cell research
Ethanol Extract of Rosa laevigata Michx. Fruit Inhibits Inflammatory Responses through NF-B/MAPK Signaling Pathways via AMPK Activation in RAW 264.7 Macrophages - PMC
Journal
Molecules (Basel, Switzerland)
Steroidal Alkaloids from the Roots of Veratrum mengtzeanum Loes. with Their Anti-Inflammatory Activities - PMC
Journal
Molecules (Basel, Switzerland)
Methylprednisolone Promotes Mycobacterium smegmatis Survival in Macrophages through NF-κB/DUSP1 Pathway - PMC
The Protective Effects of Imperatorin on Acetaminophen Overdose-Induced Acute Liver Injury.
Journal
Oxidative Medicine and Cellular Longevity
Parabacteroides distasonis-Derived Outer Membrane Vesicles Enhance Antitumor Immunity Against Colon Tumors by Modulating CXCL10 and CD8+ T Cells - PMC
Journal
Drug design, development and therapy
Synthesis and Anti-Inflammatory Activity of the Natural Cyclooxygenase-2 Inhibitor Axinelline A and Its Analogues
Journal
Journal of natural products
Characterization of the circRNA Landscape in Interleukin-4 Induced Anti-Inflammatory Microglia - PMC
Paeonol alleviates ulcerative colitis by modulating PPAR- and nuclear factor-B activation - PMC
Journal
Scientific reports
Anti-Inflammatory Effect of Xanthones from Hypericum beanii on Macrophage RAW 264.7 Cells through Reduced NO Production and TNF-, IL-1, IL-6, and COX-2 Expression - PMC
Journal
Molecules (Basel, Switzerland)
Shikonin attenuates rheumatoid arthritis by targeting SOCS1/JAK/STAT signaling pathway of fibroblast like synoviocytes
Aldehyde Dehydrogenase 2 Ameliorates LPS-Induced Acute Kidney Injury through Detoxification of 4-HNE and Suppression of the MAPK Pathway - PMC
Journal
Journal of immunology research
Effects of Fermented Green Tea Waste Extract Gels on Oxidative Damage in Short-Term Passive Smoking Mice - PMC
Journal
Gels (Basel, Switzerland)
Xanthohumol Attenuates Lipopolysaccharide-Induced Depressive Like Behavior in Mice: Involvement of NF-κB/Nrf2 Signaling Pathways
Journal
Neurochemical research
Liraglutide Attenuates Aortic Valve Calcification in a High-Cholesterol-Diet-Induced Experimental Calcific Aortic Valve Disease Model in Apolipoprotein E-Deficient Mice - PMC
Journal
Journal of cardiovascular development and disease
Isoalantolactone relieves depression-like behaviors in mice after chronic social defeat stress via the gut-brain axis - PMC
Journal
Psychopharmacology
Role of the Omentin-1 in Susceptibility to Anxiety and Depression Like Behaviors
Journal
Molecular and cellular endocrinology
Low-dose Cu exposure enhanced -synuclein accumulation associates with mitochondrial impairments in mice model of Parkinson's disease
Journal
Toxicology letters
Alipoic acid alleviates DSSinduced ulcerative colitis via modulating Keap1Nrf2 signaling pathway and inhibiting ferroptosis
Journal
Journal of the science of food and agriculture
Alipoic acid alleviates DSSinduced ulcerative colitis via modulating Keap1Nrf2 signaling pathway and inhibiting ferroptosis
Journal
Journal of the science of food and agriculture
Therapeutic efficacy of Schistosoma japonicum cystatin on sepsis-induced cardiomyopathy in a mouse model.
Journal
Parasites & Vectors
The effect and mechanism of Huangqin-Baishao herb pair in the treatment of dextran sulfate sodium-induced ulcerative colitis - PMC
Fisetin inhibits inflammation and induces autophagy by mediating PI3K/AKT/mTOR signaling in LPS-induced RAW264.7 cells
Ganoderma lucidum polysaccharides ameliorate lipopolysaccharide-induced acute pneumonia via inhibiting NRP1-mediated inflammation - PMC
Journal
Pharmaceutical biology
The protective effect of 999 XiaoErGanMao granules on the lungs and intestines of influenza A virus-infected mice - PMC
Journal
Pharmaceutical biology
Potentilla bifurca flavonoids effectively improve insulin resistance
Journal
European review for medical and pharmacological sciences
Longterm erythromycin treatment alters the airway and gut microbiota: Data from COPD patients and mice with emphysema
Journal
Respiration; international review of thoracic diseases
Design of novel balanced COX inhibitors based on natural antiinflammatory ascidian metabolites and celecoxib
Monomethyl fumarate prevents alloimmune rejection in mouse heart transplantation by inducing tolerogenic dendritic cells - PMC
Journal
Acta biochimica et biophysica Sinica
Tong?fu?li?fei decoction attenuates immunosuppression to protect the intestinal?mucosal barrier in sepsis by inhibiting the PD?1/PD?L1 signaling pathway
Impaired intestinal barrier function in a mouse model of hyperuricemia.
Journal
Molecular medicine reports
The protective effects of pretreatment with resveratrol in cyclophosphamide-induced rat ovarian granulosa cell injury: In vitro study
Iron overload enhances TBI-induced cardiac dysfunction by promoting ferroptosis and cardiac inflammation
Journal
Biochemical and biophysical research communications
Effect of IGF-1C domain-modified nanoparticles on renal ischemia-reperfusion injury in mice - PMC
Ganoderma lucidum spore oil synergistically enhances the function of cyclophosphamide in the prevention of breast cancer metastasis
Journal
Journal of the Chinese Medical Association : JCMA
In vitro and in silico analysis of ‘Taikong blue lavender essential oil in LPS-induced HaCaT cells and RAW264.7 murine macrophages - PMC
Journal
BMC complementary medicine and therapies
Gualou Guizhi Granule Suppresses LPS-Induced Inflammatory Response of Microglia and Protects against Microglia-Mediated Neurotoxicity in HT-22 via Akt/NF-κB Signaling Pathways
Journal
Evid Based Complement Alternat Med
An In Vitro Verification of the Effects of Paeoniflorin on Lipopolysaccharide-Exposed Microglia
Journal
Evid Based Complement Alternat Med
The role of ZC3H12D-regulated TLR4-NF-B pathway in LPS-induced pro-inflammatory microglial activation
Journal
Neuroscience letters
Prophylactic supplementation with Bifidobacterium infantis or its metabolite inosine attenuates cardiac ischemia/reperfusion injury - PMC
HTD4010 attenuates myocardial injury in mice with septic cardiomyopathy by promoting autophagy via the AMPK/mTOR signaling pathway
Journal
Nan fang yi ke da xue xue bao = Journal of Southern Medical University
Inhalation of electronic cigarettes slightly affects lung function and inflammation in mice - PMC
Journal
Frontiers in toxicology
Xiaoqinglong decoction suppresses childhood cough variant asthma and inhibited the body inflammatory response by regulating IL-6/STAT3 signalling pathway - PMC
Journal
Annals of medicine and surgery (2012)
Mesenchymal Stem Cells Inhibit Epithelial-to-Mesenchymal Transition by Modulating the IRE1 Branch of the Endoplasmic Reticulum Stress Response - PMC
Journal
Stem cells international
Blood-Brain Barrier Breakdown and Astrocyte Reactivity Evident in the Absence of Behavioral Changes after Repeated Traumatic Brain Injury