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Human IL-4 Sanwich CLIA Immunoassay
| Recommended Concentration | Sample | |
|---|---|---|
| CLIA Capture | 1-4ug/mL | Rabbit anti-Human IL-4(CAP)(Cat. No.RM17744) |
| CLIA Detection | 0.5-2ug/mL | Rabbit anti-Human IL-4(DET)(Cat. No.RM17745) |
| Standard | 0.1-10ng/mL | Recombinant Human IL-4 Protein |
Interleukin-4, is a cytokine that induces differentiation of naive helper T cells (Th0 cells to Th2 cells). In the presence of IL-4 and IL-13, cytokines that are produced in a Th-2 type response, particularly during allergy and parasitic infections, macrophages become differentially activated, And this cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. Recently, researcher found that the cytokine IL-4 plays a key role in development of innate CD8+ T cells in the thymus of several gene-deficient mouse strains, including Itk, KLF2, CBP and Id3, without previous exposure to antigen.
