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Human TNFR1 Sanwich ELISA Immunoassay
Recommended Concentration | Sample | |
---|---|---|
ELISA Capture | 1-4ug/mL | Rabbit anti-Human TNFR1 (CAP)(Cat. No.RM17949) |
ELISA Detection | 0.25-0.0625ug/mL | Rabbit anti-Human TNFR1 (DET)(Cat. No.RM17950) |
Standard | 7.81-500pg/mL | Recombinant Human TNFR1 Protein |
Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.