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Rabbit anti-Human IL-1β mAb(CAP) (RM17965)

This standard curve is only for demonstration purposes. A standard curve should be generated for each assay.

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货号: RM17965
促销价:   ¥2100
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详细信息

产品名称
Rabbit anti-Human IL-1β mAb(CAP)
货号
RM17965
免疫原
Recombinant fusion protein containing a sequence corresponding to amino acids 117-269 of human IL-1β (NP_000567.1).
纯化方式
Affinity purification
同种型
Rabbit IgG
存储溶液
Supplied as a 0.2um filtered solution in PBS,PH 7.4 containing Human IL-1β Antibody.
存储条件
Store at -20℃. Avoid repeated freeze-thaw cycles.

* This package insert must be read in its entirety before using this product.

应用

Human IL-1β Sandwich Immunoassay

  Recommended
Concentration
Sample
MultiplexCapture3-20ug/mLRabbit anti-Human IL-1β mAb(Cat. No.RM17965)
Detection0.017-2ug/mLRabbit anti-Human IL-1β mAb(Cat. No.RM17734)
Standard13.72-10000pg/mLRecombinant Human IL-1 beta Protein(Cat. No. RP00002)

背景信息

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. Similarly, IL-1B has been implicated in human osteoarthritis pathogenesis. Patients with severe Coronavirus Disease 2019 (COVID-19) present elevated levels of pro-inflammatory cytokines such as IL-1B in bronchial alveolar lavage fluid samples. The lung damage induced by the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is to a large extent, a result of the inflammatory response promoted by cytokines such as IL-1B. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.

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