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This standard curve is only for demonstration purposes. A standard curve should be generated for eachassay.
* This package insert must be read in its entirety before using this product.
Mouse PD-L1/CD274 Sandwich ELISA Immunoassay
| Recommended Concentration | Sample | |
|---|---|---|
| ELISA Capture | 1-4ug/mL | Rabbit anti-Mouse PD-L1/CD274(CAP)(Cat. No.RM98006) |
| ELISA Detection | 0.25-1ug/mL | Rabbit anti- Mouse PD-L1/CD274 (DET)(Cat. No.RM98007) |
| Standard | 15.62-1000pg/mL | Recombinant Mouse PD-L1/CD274(Cat. No.RP01158) |
Plays a critical role in induction and maintenance of immune tolerance to self (PubMed:11238124).As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response (PubMed:11238124).Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10) (PubMed:11015443, PubMed:12719480).3 PublicationsThe PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival (PubMed:12218188, PubMed:27281199).The interaction with PDCD1/PD-1 inhibits cytotoxic T lymphocytes (CTLs) effector function (PubMed:12218188).The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy (PubMed:12218188).2 Publications
