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This standard curve is only for demonstration purposes. A standard curve should be generated for eachassay.
This standard curve is only for demonstration purposes. A standard curve should be generated for eachassay.
* This package insert must be read in its entirety before using this product.
Human CD177 Sanwich ELISA Immunoassay
| Recommended Concentration | Sample | |
|---|---|---|
| ELISA Capture | 1-4ug/mL | Rabbit anti-Human CD177 (CAP)(Cat. No.RMK0015) |
| ELISA Detection | 0.0125-0.05ug/mL | Rabbit anti-Human CD177 (DET)(Cat. No.RMK0016) |
| Standard | 39.06-2500pg/mL | Recombinant Human CD177 Protein |
In association with beta-2 integrin heterodimer ITGAM/CD11b and ITGB2/CD18, mediates activation of TNF-alpha primed neutrophils including degranulation and superoxide production .In addition, by preventing beta-2 integrin internalization and attenuating chemokine signaling favors adhesion over migration .Heterophilic interaction with PECAM1 on endothelial cells plays a role in neutrophil transendothelial migration in vitro .However, appears to be dispensable for neutrophil recruitment caused by bacterial infection in vivo .Acts as a receptor for the mature form of protease PRTN3 allowing its display at the cell surface of neutrophils .By displaying PRTN3 at the neutrophil cell surface, may play a role in enhancing endothelial cell junctional integrity and thus vascular integrity during neutrophil diapedesis.
