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This standard curve is only for demonstration purposes. A standard curve should be generated for each assay.
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Human Fas Ligand/TNFSF6 Sandwich ELISA Immunoassay
| Recommended Concentration | Sample | |
|---|---|---|
| ELISA Capture | 1-4 ug/mL | Rabbit anti-Human Fas Ligand/TNFSF6 (CAP)(Cat. No.RMK0035) |
| ELISA Detection | 0.0625-0.25ug/mL | Rabbit anti-Human Fas Ligand/TNFSF6 (DET)(Cat. No.RMK0036) |
| Standard | 15.625-1000pg/mL | Recombinant Human Fas Ligand/TNFSF6 Protein(Cat. No.RP02353) |
Fas ligand (FasL), also known as TNFSF6, CD178, or CD95L, is a member of the tumor necrosis factor (TNF) superfamily. Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells.Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development .Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses (By similarity).TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance.Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis .Human FasL was first isolated using reverse polymerase chain reaction of peripheral blood lymphocyte mRNA. The gene for FasL codes for a 40 kDa type II membrane spanning protein containing 281 amino acids (aa). FasL is 76.9% identical to its mouse counterpart at the aa level and is constitutively expressed primarily in activated T lymphocytes and immune-privileged tissues including eye, testis, and placenta. FasL may also be upregulated following exposure to UV light or cytotoxic drugs.
