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This standard curve is only for demonstration purposes. A standard curve should be generated for eachassay.
* This package insert must be read in its entirety before using this product.
Human TNF RII Sandwich Immunoassay
| Recommended Concentration | Sample | |
|---|---|---|
| ELISA Capture | 1-4 μg/mL | Rabbit anti-Human TNF RII mAb (Cat. No. RMK0085) |
| ELISA Detection | 0.17-0.67 μg/mL | Rabbit anti-Human TNF RII mAb (Cat. No. RMK0086) |
| Standard | 15.63-1000 pg/mL | Recombinant Human TNFRSF1B/TNF-R2/CD120b Protein (Cat. No. RP00252) |
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways.
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