Rabbit anti-Human Amyloid beta (1-42) mAb(CAP) (RMK0189)

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货号: RMK0189

详细信息

产品名称

Rabbit anti-Human Amyloid beta (1-42) mAb(CAP)

货号

RMK0189

免疫原

Recombinant Human Amyloid beta (1-42)

纯化方式

Affinity purification

同种型

Rabbit IgG

存储溶液

Supplied as a 0.2um filtered solution in PBS with 0.1%Braveds MB-1,PH 7.8.

CrossReactivity

存储条件

This antibody can be stored at 2℃-8℃ for one monthwithout detectable loss of activity. Antibody products are stable for twelve months fromdate of receipt when stored at -20℃ to -80℃. Preservative-Free.Avoid repeated freeze-thaw cycles.

* This package insert must be read in its entirety before using this product.

应用

Human Amyloid beta (1-42) Sandwich ELISA Immunoassay

	Recommended Concentration	Sample
ELISA Capture	1-4ug/mL	Rabbit anti-Human Amyloid beta (1-42) mAb(CAP)(Cat. No.RMK0189)
ELISA Detection	0.033-0.13ug/mL	Rabbit anti-Human Amyloid beta (1-42) mAb(DET)(Cat. No.RMK0190)
Standard	7.8125-500pg/mL	Recombinant Human Amyloid beta (1-42) Protein

背景信息

Amyloid-beta peptides are lipophilic metal chelators with metal-reducing activity. Bind transient metals such as copper, zinc and iron. In vitro, can reduce Cu2+ and Fe3+ to Cu and Fe+2+, respectively. Amyloid-beta protein 42 is a more effective reductant than amyloid-beta protein 40. Amyloid-beta peptides bind to lipoproteins and apolipoproteins E and J in the CSF and to HDL particles in plasma, inhibiting metal-catalyzed oxidation of lipoproteins. APP42-beta may activate mononuclear phagocytes in the brain and elicit inflammatory responses. Promotes both tau aggregation and TPK II-mediated phosphorylation. Interaction with overexpressed HADH2 leads to oxidative stress and neurotoxicity. Also binds GPC1 in lipid rafts.