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Human sEPCR multiplex assay
| Recommended Concentration | Sample | |
|---|---|---|
| Multiplex Capture | 3-20ug/mL | Rabbit anti-Human sEPCR mAb(Cat. No.RMK0394) |
| Multiplex Detection | 0.017-2ug/mL | Rabbit anti-Human sEPCR mAb(Cat. No.RMK0395) |
| Standard | 6.86-5000pg/mL | Recombinant Human sEPCR Protein |
EPCR is a type I transmembrane glycoprotein in the CD1/MHC family. It is expressed most strongly in the endothelial cells of arteries and veins in heart and lung. Membrane bound EPCR is released by metalloproteolytic cleavage to generate the soluble receptor. Protein C is a vitamin K-dependent serine protease that plays a major role in blood coagulation. Binding of Protein C to EPCR leads to the proteolytic activation of PAR1 (protease-activated receptor 1) on endothelial cells and subsequent up-regulation of Protein C-induced genes
