Human IL-12 R beta 1 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
Human IL-12 R beta 1 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
Immobilized Human IL-12B, His Tag at 1 μg/mL (100 μL/well) on the plate. Dose response curve for Human IL-12 R beta 1, hFc Tag with the EC50 of 0.26 μg/mL determined by ELISA.
Human IL12RB1 is an autosomal gene that is essential for mycobacterial disease resistance and T cell differentiation. Lung and T cell IL12RB1 expression is allele-biased, and the extent to which cells express one IL12RB1 allele is unaffected by activation. Furthermore following its expression the IL12RB1 pre-mRNA is processed into either IL12RB1 Isoform 1 (IL12Rβ1, a positive regulator of IL12 responsiveness) or IL12RB1 Isoform 2 (a protein of heretofore unknown function).
