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Granulocyte-Macrophage Colony-Stimulating Factor Receptor Subunit α (CSF2RA) is a single-pass type Imembrane protein which belongs to the type I cytokine receptor family of Type 5 subfamily. The CSF2RA geneis found in the pseudoautosomal region (PAR) of the X and Y chromosomes with some of the isoforms beingmembrane-bound and others being soluble. CSF2RA is a low affinity receptor for granulocyte-macrophagecolony-stimulating factor. CSF2RA transduces a signal that results in the proliferation, differentiation, andfunctional activation of hematopoietic cells. Defects in CSF2RA are the cause of pulmonary surfactantmetabolism dysfunction type 4 (SMDP4).