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Recombinant Mouse IGFBP-6 Protein (RP00683)

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Recombinant Mouse IGFBP-6 Protein was determined by SDS-PAGE under reducing conditions with Coomassie Blue.

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货号: RP00683
促销价：   ￥840
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详细信息

种属
Mouse
表达宿主
HEK293 cells
描述
Recombinant Mouse IGFBP-6 Protein is produced by Human Cells expression system. The target protein is expressed with sequence (Ala26-Gly238) of mouse IGFBP-6 (Accession #P47880) fused with a 6×His tag at the C-terminus.
标签
C-6×His
纯度
> 95% by SDS-PAGE.
内毒素
< 1 EU/μg of the protein by LAL method.
制剂
Lyophilized from a 0.2 μm filtered solution of PBS, EDTA,DTT,pH7.4.Contact us for customized product form or formulation.
储存
Store the lyophilized protein at -20°C to -80 °C for long term.
After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.未开盖的干粉蛋白在 -20°C至-80°C可保存12个月；
复溶之后，蛋白溶液在-20°C及以下可保存3个月，在2-8℃可保存1周。
复溶
Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water.收到重组蛋白产品之后请检查蛋白冻干粉末是否贴于瓶底，如果粉末浮起，开盖之前请先低温离心。将蛋白用说明书中指定的缓冲液复溶至0.1-0.5 mg/mL（请注意蛋白复溶浓度不能低于0.1 mg/mL），室温平衡5-10 min保证充分溶解，复溶过程中请不要剧烈涡旋及吹打蛋白溶液。如需长期储存，建议复溶时添加载体蛋白或者稳定剂（如0.1% BSA, 5% HSA, 10% FBS 或者 5% 海藻糖），同时将复溶后的蛋白溶液按照需求进行分装，储存于-20°C至-80°C，随取随用，避免反复冻融。

蛋白复溶计算器

请在蛋白复溶计算器中输入蛋白总质量和所需终浓度，快速计算您需要添加溶液的体积吧！
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背景信息

Insulin-like growth factors (IGFs) comprise a family of endocrine, paracrine and autocrine polypeptidesconsisting of the ligands IGF1 and IGF2, two receptors (IGF1R, IGF2R), at least 6 IGF-binding proteins (IGFBPs)and IGFBP proteases. Among the binding proteins, IGFBP6 is unique because of its N-terminal disulfide linkagesand its marked binding preference for IGF2. It is a potent inhibitor of the interaction between IGF2 and itsreceptor IGF1R, thus preventing major functions of IGF2, such as induction of proliferation, differentiation, celladhesion, or colony formation. In particular, IGFBP-6 inhibited the growth of neuroblastoma andrhabdomyosarcoma xenografts. GFBP-6 is expressed in many tissues, including lung, liver, gut and the centralnervous system.

基因ID
16012
Swiss Prot
P47880
别名
Insulin-like growth factor-binding protein 6; IBP-6; IGF-binding protein 6; IGFBP-6; Igfbp6; IBP6;IGF binding protein 6; insulin-like growth factor-binding protein 6
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