Recombinant Human KLRG1/CLEC15A/CD369 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Leu60-Phe195) of human KLRG1/CLEC15A/CD369 (Accession #NP_001316028.1) fused with a raFc tag at the N-terminus.
KLRG1 (killer cell lectin?like receptor G1), also called MAFA (mast cell function associated), is an inhibitory type II transmembrane glycoprotein of the C-type lectin family, designated CLEC15A.Within the ECD, Human KLRG1 shares 57% and 80% aa sequence identity with mouse and rat KLRG1, respectively.KLRG1 is expressed on subpopulations of CD8+, CD4+, regulatory, and gamma/delta T cells as well as on NK cells. KLRG1 is expressed on T cells found in cord blood, but it is down-regulated postnatally and is subsequently re-expressed on antigen-exposed T cells. It is expressed by a greater proportion of CD8+ T cells in the elderly and by virus-specific CD8+ T cells during chronic virus infection. KLRG1 binds to E-, N-, and R-Cadherins, triggering ITIM?dependent KLRG1 signaling and inhibition of T cell activation. The response is bi?directional, as KLRG1 binding to E-Cadherin on dendritic cells (DC) can induce an anti-inflammatory DC phenotype (increased IL-10 production and decreased IL?6 and TNF-alpha production).
