产品和服务 / 产品类型 / 细胞系&裂解液 / KO细胞系
Measured by its ability to inhibit proliferation of MPC-11 cells. The ED50 for this effect is 3.215-12.86 ng/mL, corresponding to a specific activity of 7.78×104~3.11×105 units/mg.
Recombinant Human/Mouse/Rat mature Activin A/INHBA Protein was resolved with SDS PAGE under reducing (R) and non-reducing (NR) conditions.
The inhibin beta A subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta A subunit forms a homodimer, activin A, and also joins with a beta B subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion. Finally, it has been shown that the beta A subunit mRNA is identical to the erythroid differentiation factor subunit mRNA and that only one gene for this mRNA exists in the human genome.
