Recombinant Mouse GPVI Protein was determined by SDS-PAGE with Coomassie Blue, showing bands at 50-60 kDa.
The purity of Mouse GPVI is greater than 95% as determined by SEC-HPLC.
Although platelets are best known for their role in hemostasis, they are also crucial in development, host defense, inflammation, and tissue repair. Many of these roles are regulated by the immune-like receptors glycoprotein VI (GPVI) and C-type lectin receptor 2 (CLEC-2), which signal through an immunoreceptor tyrosine-based activation motif (ITAM). GPVI is activated by collagen in the subendothelial matrix, by fibrin and fibrinogen in the thrombus, and by a remarkable number of other ligands.
