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Recombinant Human Serpin E2/PN1 Protein (RP03178LQ)

Recombinant Human TNFRSF19/TROY Protein was determined by SDS-PAGE with Coomassie Blue, showing a band at 50 kDa.

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货号: RP03178LQ
促销价:   ¥1200
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详细信息

种属
Human
表达宿主
HEK293 cells
Calculated MW
42.7 KDa
Observed MW
50 KDa
标签
C-His
纯度
> 95% by SDS-PAGE.
内毒素
< 1 EU/μg of the protein by LAL method.
制剂
Supplied as a 0.22 μm filtered solution in 20mM Tris-HCl, 150mM NaCl, pH 8.0.
描述
Recombinant Human Serpin E2/PN1 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser20-Pro397) of Human Serpin E2/PN1 (Accession #NP_001130000.1) fused with a 6×His tag at the C-terminus.
储存
Store at -70℃. This product is stable at ≤ -70℃ for up to 1 year from the date of receipt. For optimal storage, aliquot into smaller quantities after centrifugation and store at recommended temperature. Avoid repeated freeze-thaw cycles.未开盖的干粉蛋白在 -20°C至-80°C可保存12个月;
复溶之后,蛋白溶液在-20°C及以下可保存3个月,在2-8℃可保存1周。

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背景信息

Serpin E2 is a secreted protein that belongs to the serpin family. Serpin E2 is a serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Serpin E2 expression is weak or absent in all normal pancreas and chronic pancreatitis tissue. In contrast, it was strongly over-expressed in the majority of pancreatic carcinoma as well as gastric and colorectal cancer samples. Serpin E2 promotes neurite extension by inhibiting thrombin. It also can bind heparin. It has been shown that Serpin E2 is a novel target of ERK signaling involved in human colorectal tumorigenesis. It plays an important role in controlling male fertility because its knockout male mice show a marked impairment in fertility from the onset of sexual maturity and its abnormal expression is found in the semen of men with seminal dysfunction.

基因ID
Swiss Prot
别名
Glia-derived Nexin; GDN; Peptidase inhibitor 7; PI-7; Protease nexin 1; PN-1; Protease nexin I; Serpin E2; SERPINE2; PI7; PN1