Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP4 plays a role in bone morphogenesis, and may also act as a regulator of adult uterine morphology and function. SFRP4 may also increase apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling, and it has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake.