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SB431542 (TGF-β/Smad抑制剂) (RPM0014)

Chemical structure of SB431542, CAS No.:301836-41-9

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货号: RPM0014
价 格:  300.00
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详细信息

靶点
SB431542; SB 431542; SB-431542; TGF-β/Smad抑制剂; ALK抑制剂
细胞系
384.39
突变描述
货号###名称### 规格 |||RPM0014###SB431542 (TGF-β/Smad抑制剂)###1mg/5mg||| - ### 说明书###1 份

Mammalian cells such as human, rat and mouse cells are normally diploid with two alleles.
Homozygote: both alleles were knocked out, mRNA has no signal, no expression of proteins.
Heterozygote: only one allele was knocked out, the mRNA transcript levels was decreased compared to wild type, and the protein expression levels was also lower than that of the wild type.
产品组成
本产品仅用于科研。本产品仅用于科研。1. 细胞生物学研究|2. 肿瘤研究|3. 炎症研究
物种
301836-41-9
保存条件
Store at -20℃.store at low temperature,store under nitrogen
Powder: -20°C for 3 years
In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature.store under nitrogen,keep away from moisture,store at low temperature
Powder: -20°C for 3 years
In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature.
运输条件
本产品仅用于科研。该物质可用于多领域研究:干细胞研究中抑 TGF-β 通路促其向特定细胞分化,肿瘤研究中阻肿瘤细胞 EMT 抑转移,还能在纤维化疾病研究中抑成纤维细胞活化并助力药物筛选。

背景信息

SB-431542 是一种 ALK5/TGF-β type I Receptor 的抑制剂 (IC50=94 nM),具有选择性。SB 431542 对 ALK4 和 ALK7 也有抑制活性,但对其他蛋白没有抑制作用。SB 431542 可以用于干细胞的诱导分化。

别名
SB431542; SB 431542; SB-431542; TGF-β/Smad抑制剂; ALK抑制剂