<1EU/mg (<0.001EU/μg)Determined by LAL gel clotting assay
Sterility
0.2 μm filtration
Aggregation
<5% Determined by SECP
Purity
94.03% Determined by SEC-HPLC
产品信息
Production
Purified from cell culture supernatant in an animal-free facility
Purification
Protein A or G purification
Storage
Store at 2 - 8℃. 2 - 8°C for up to 4 weeks and -80°C for long term storage (Avoid repeated freezing and thawing)
背景信息
Adalimumab, the first fully human monoclonal antibody drug approved by FDA, binds to TNFα, inactivates TNF receptors, and downregulates the inflammatory reactions associated with a variety of autoimmune diseases, such as rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn's disease, ulcerative colitis, moderate to severe chronic psoriasis and juvenile idiopathic arthritis.Mainly produced by activated macrophages (M1), Tumor necrosis factor (TNF, cachexin, cachectin, tumor necrosis factor alpha, TNFα) plays important roles in the regulation of immune cells. As a member of a group of cytokines that stimulate the acute phase reaction, TNF is involved in systemic inflammation and able to induce fever, apoptotic cell death, cachexia, inflammation, and to inhibit tumorigenesis and viral replication and respond to sepsis via IL1 & IL6 producing cells. Dysregulation of TNF expression could have serious impact in a variety of human diseases including Alzheimer's disease, cancer, major depression and inflammatory bowel disease.
