根据最新的研究动态(Nature 2020 Apr 30. doi: 10.1038/s41586-020-2286-9.),有69种化合物(包括29种FDA批准的药物、12种临床试验药物和28种临床前化合物)有希望用于新冠肺炎的治疗。进一步研究这些潜在靶向药物相关蛋白靶点,会极大的加速新冠治疗药物的开发。

SARS-CoV-2 治疗潜在药物靶点及相关抗体

A11545eEF1A1 Rabbit mAb

应用:WB, IF 物种:H, M, R

A12677Brd4 Rabbit mAb

应用:WB, IHC 物种:H

A1402VCP Rabbit mAb

应用:WB, IF 物种:H, M, R

A15788[KO Validated] SEC61B Rabbit pAb

应用:WB, IF 物种:H, M, R

A19625CRM1 Rabbit mAb

应用:WB, IHC, IF 物种:H, M, R

A4612ACE2 Rabbit mAb

应用:WB,IHC 物种:H, M, R

A9126TMPRSS2 Rabbit mAb

应用:WB, IHC 物种:H, M, R

A9208IMPDH2 Rabbit mAb

应用:WB,IF 物种:H, M, R

分类 靶点 病毒相关蛋白 化合物名称 药物现状 参考文献 (PMID或DOI) ABclonal相关研究工具
病毒入侵 ACE2 Captopril Approved (Hypertension) 9187274 A4612
Lisinopril Approved (Hypertension) 12540854
Captopril Approved (Hypertension) 9187274
Lisinopril Approved (Hypertension) 12540854
TMPRSS2 Camostat Approved (Pancreatitis) 22496216 A9126
Nafamostat Approved (Anticoagulant) 10.1128/AAC.01043-16
病毒复制 Cyclophilin Compound 2 Pre-clinical 30074795 A5097, A4861, RK01236
PI4K-IIIβ Compound 10 Pre-clinical 26885694 A16416
核酸合成 IMPDH2 Nsp14 Mycophenolic acid Approved (Organ rejection) 5799033 A9208
Ribavirin Approved (Viral infection) 22555152
Sanglifehrin A Pre-clinical 28076787
Merimepodib Clinical Trial 10878288
DCTPP1 Orf9b ZINC1775962367 Pre-clinical 26771665
ZINC4326719 28145708
ZINC4511851 28655422
转录调节 BRD2/4 E ABBV-744 Clinical Trial 31969702 A12677
dBET6 Pre-clinical 29764999
MZ1 Pre-clinical 26035625
CPI-0610 Clinical Trial 26815195
JQ1 Pre-clinical 24391744
RVX-208 Clinical Trial 24391744
HDAC2 Nsp5 Apicidin Pre-clinical 17868033 A19626
Valproic Acid Approved (CNS diseases, Cancer) 11742974; 12840003; 21874153
DNMT1 Orf8 Azacitidine Approved 15899874 A19679
出核运输 XPO1 Nsp4/9/Orf6 Selinexor Approved 30115935 A19625
RAE1 A6713
翻译调节 eEF1A Ternatin 4 Pre-clinical 26651998 A11545
eIF4E 4E2RCat Pre-clinical 21507972 A2162
eIF4G A7552, A19990
EIF4E2/H Nsp2 Zotatifin Clinical Trial 10.1158/1538-7445.AM2019-2698 A4305
LARP1 N Rapamycin Approved (Organ rejection) 15896331 A4543
Sapanisertib Clinical Trial 21651476
MNK1 Tomivosertib Clinical Trial 29526098; 30643286
MNK2
线粒体核糖体 MRPs Chloramphenicol Approved (Bacterial infection) '23148581 A4945, A4527, A5897, A5979, A13197
Tigecycline 28700943
Linezolid 16127068
蛋白加工 ER α-Glucosidase IHVR-19029 Clinical Trial 29253498; 28197304 A12725, A19876
GLA Nsp14 Migalastat Approved (Fabry disease) 10866822 A5119
FKBP7/10 Orf8 Rapamycin, FK-506 Approved (Organ rejection) 15896331; 9806833 A19870
PLOD1/2 Orf8 Minoxidil Approved (Hair loss) 30481795
Sec61 PS3061 Pre-clinical 30550790 A15788
细胞器酸化 ATP6AP1 Nsp6 Bafilomycin A1 Pre-clinical 9572882 A1209
ATP6V1A M A14706
蛋白降解 CUL2 Orf10 Pevonedistat Clinical Trial 19360080 A5076
受体 SIGMAR1 Nsp6 Chloroquine Approved (Malaria) 30042674 A5479
SIGMAR1 Nsp6 E-52862 Clinical Trial 22784008
SIGMAR1 Nsp6 PD-144418 Pre-clinical 9144641
SIGMAR1 Nsp6 RS-PPCC Pre-clinical 17328523
SIGMAR1 Nsp6 PB28 Pre-clinical 16891467
TMEM97 Orf9c Pre-clinical 16891467
SIGMAR1 Nsp6 Haloperidol Approved (CNS diseases) 7925616 A5479
TMEM97 Orf9c Approved (CNS diseases) 7925616
F2RL1 Orf9c AC-55541 Pre-clinical 18720984 A5103
F2RL1 Orf9c AZ8838 Pre-clinical 28445455
F2RL1 Orf9c GB110 Pre-clinical 20873792
F2RL1 Orf9c AZ3451 Pre-clinical 28445455
转运蛋白 SLC6A15 Nsp6 Loratadine Approved 25318072
SLC1A3 M UCPH-101 Pre-clinical 19161278 A9712
ABCC1 Orf9c Daunorubicin Approved (Cancer) 9647783 A3027, A11153
ABCC1 Orf9c S-verapamil Approved (Hypertension) 17646169
细胞分裂 NEK9 Nsp9 Dabrafenib Approved (Cancer) 29112787 A17806
CEP250 Nsp13 WDB002 Clinical Trial US Patent US20170097-359A1
VCP Orf10 CB5083 Clinical Trial 26565666 A1402
VCP Orf10 DBeQ Pre-clinical 21383145
细胞骨架 MARK2/3 Orf9b Midostaurin Approved (Cancer) 18183025 A6512
MARK2/3 Orf9b Ruxolitinib Approved (Myelofibrosis) 22037378
多功能激酶 CSNK2A2 N Silmitasertib Approved (Cancer) 21159648; 21174434 A1616, A13481
TMCB Pre-clinical 22115617
PRKACA Nsp13 H-89 Pre-clinical 2156866 A0798, AP0557
免疫与炎症 RIPK1 Nsp12 Ponatinib Approved (Cancer) 25801024 A19580
TBK1 Orf9b Nsp13 ZINC95559591 Pre-clinical 23099093 A3458, AP1026
PTGES2 Nsp7 Indomethacin Approved (Inflammation, Pain) 5284360 A7137, A13440
氧化应激 LOX Orf8 CCT 365623 Pre-clinical 31070916 A11504
能量代谢 NDUFs Nsp7, Orf9c Metformin Approved (Diabetes) 24843020 A4602, A8691, A8013, A12858
儿茶酚胺代谢 COMT Nsp7 Entacapone Approved (Parkinson's disease) 1407012; 9681662 A4435, A18085
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