Naked mole-rat brown fat thermogenesis is diminished during hypoxia through a rapid decrease in UCP1
Ambient particulate matter triggers dysfunction of subcellular structures and endothelial cell apoptosis through disruption of redox equilibrium and calcium homeostasis
Journal
Journal of Hazardous Materials
Periplocin suppresses the growth of colorectal cancer cells by triggering LGALS3 (galectin 3)-mediated lysophagy
ROS-Drp1-mediated mitochondria fission contributes to hippocampal HT22 cell apoptosis induced by silver nanoparticles - PMC
PM2. 5 induces autophagy and apoptosis through endoplasmic reticulum stress in human endothelial cells
Journal
The Science of the total environment
Cancer-derived exosome miRNAs induce skeletal muscle wasting by Bcl-2-mediated apoptosis in colon cancer cachexia
Journal
Mol Ther Nucleic Acids
Pyridoxine induces monocyte-macrophages death as specific treatment of acute myeloid leukemia
TSSK4 upregulation in alveolar epithelial type-II cells facilitates pulmonary fibrosis through HSP90-AKT signaling restriction and AT-II apoptosis
CDK13 phosphorylates the translation machinery and promotes tumorigenic protein synthesis
Compound α-keto acid tablet supplementation alleviates chronic kidney disease progression via inhibition of the NF-kB and MAPK pathways.
Journal
Journal of translational medicine
Size-optimized simvastatin TPGS modified lipid nanocapsules for targeting epithelial-to-mesenchymal transition in hepatocellular carcinoma: role of PTEN/AKT
Journal
Expert opinion on drug delivery
GL-V9 exerts anti-T cell malignancies effects via promoting lysosome-dependent AKT1 degradation and activating AKT1/FOXO3A/BIM axis.
Journal
Free radical biology & medicine
Species
Homo sapiens, Mus musculus
Etanercept reduces neuroinflammation and lethality in mouse model of Japanese encephalitis
Journal
Journal of infectious diseases
Modulation of apoptosis and Inflammasome activation in chondrocytes: co-regulatory role of Chlorogenic acid - PMC
Journal
Cell communication and signaling : CCS
Effects of different protein phosphorylation levels on the tenderness of different ultimate pH beef
Journal
Food research international (Ottawa, Ont.)
Isothiocyanate Iberin inhibits cell proliferation and induces cell apoptosis in the progression of ovarian cancer by mediating ROS accumulation and GPX1 expression
Journal
Biomed Pharmacother
Exercise attenuates angiotensinⅡ-induced muscle atrophy by targeting PPARγ/miR-29b
Journal
J Sport Health Sci
LW-213, a newly synthesized flavonoid, induces G2/M phase arrest and apoptosis in chronic myeloid leukemia.
Journal
Acta Pharmacologica Sinica
Toxic effects of bisphenol S on mice heart and human umbilical cord endothelial cells
Journal
Ecotoxicology and environmental safety
Exploratory study on the potential regulating role of Peroxiredoxin 6 on proteolysis and relationships with desmin early postmortem
Eleutheroside E alleviates cerebral ischemia-reperfusion injury in a 5-hydroxytryptamine receptor 2C (Htr2c)-dependent manner in rats
Apocynum venetum leaf extract alleviated doxorubicin-induced cardiotoxicity through the AKT/Bcl-2 signaling pathway
Species
Apocynum venetum leaf
Chlorogenic acid suppresses miR-460a in the regulation of Bcl-2, causing interleukin-1β reduction in thiram exposed chondrocytes via caspase-3/caspase-7 pathway
Journal
Phytomedicine : international journal of phytotherapy and phytopharmacology
A prospective diagnostic and prognostic biomarker for hepatocellular carcinoma that functions in glucose metabolism regulation: Solute carrier family 37 member 3
Journal
Biochimica et biophysica acta. Molecular basis of disease
1,25(OH) 2 D 3 Mitigates Oxidative Stress-Induced Damage to Nucleus Pulposus-Derived Mesenchymal Stem Cells through PI3K/Akt Pathway
Journal
Oxidative medicine and cellular longevity
The Antitumoral/Antimetastatic Action of the Flavonoid Brachydin A in Metastatic Prostate Tumor Spheroids In Vitro Is Mediated by (Parthanatos) PARP-Related Cell Death
Immunoliposome co-delivery of bufalin and anti-CD40 antibody adjuvant induces synergetic therapeutic efficacy against melanoma
Journal
International Journal of Nanomedicine
Polycyclic polyprenylated acylphloroglucinols from Garcinia xanthochymus fruits exhibit antitumor effects by inhibition of STAT3 signaling pathway
Identification of Important Factors Causing Developmental Arrest in Cloned Pig Embryos by Embryo Biopsy Combined with Microproteomics - PMC
Journal
International journal of molecular sciences
Xanthones from Gentianella acuta (Michx.) Hulten Ameliorate Colorectal Carcinoma via the PI3K/Akt/mTOR Signaling Pathway - PMC
Journal
International journal of molecular sciences
The marine metabolite SZ-685C induces apoptosis in primary human nonfunctioning pituitary adenoma cells by inhibition of the Akt pathway in vitro
Species
Homo sapiens,Rattus norvegicus
15, 16-Dihydrotanshinone I Inhibits Hemangiomas through Inducing Pro-apoptotic and Anti-angiogenic Mechanisms in Vitro and in Vivo.
Journal
Frontiers in Pharmacology
6-Gingerol protects against cerebral ischemia/reperfusion injury by inhibiting NLRP3 inflammasome and apoptosis via TRPV1/FAF1 complex dissociation-mediated autophagy
Journal
Int Immunopharmacol
TSP-1 increases autophagy level in cartilage by upregulating HSP27 which delays progression of osteoarthritis
Journal
International immunopharmacology
Atorvastatin protects against cyclophosphamide-induced thyroid injury in rats via modulation of JNK/ERK/p38 MAPK signaling pathway
Journal
International immunopharmacology
MiR-26b-3p Promotes Intestinal Motility Disorder by Targeting FZD10 to Inhibit GSK3/-Catenin Signaling and Induce Enteric Glial Cell Apoptosis
Journal
Molecular neurobiology
In vitro antioxidant and antiproliferative effects of ellagic acid and its colonic metabolite, urolithins, on human bladder cancer T24 cells
Journal
Food and Chemical Toxicology
Effects of prenatal acetaminophen exposure at different stages, doses and courses on articular cartilage of offspring mice
Journal
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Adropin attenuates pancreatitis-associated lung injury through PPAR phosphorylation-related macrophage polarization - PMC
Journal
International journal of molecular medicine
Synthesis and evaluation of redox-sensitive gonadotropin-releasing hormone receptor-targeting peptide conjugates.
Journal
Bioorganic chemistry
Oroxylin a promoted apoptotic extracellular vesicles transfer of glycolytic kinases to remodel immune microenvironment in hepatocellular carcinoma model
Journal
European journal of pharmacology
A composition of ursolic acid derivatives from Ludwigia hyssopifolia induces apoptosis in throat cancer cells via the Akt/mTOR and mitochondrial signaling pathways
Journal
Journal of ethnopharmacology
Chlorogenic acid inhibits apoptosis in thiram-induced tibial dyschondroplasia via intrinsic pathway
Journal
Environ Sci Pollut Res Int
ZYY-B-2, a novel ALK inhibitor, overcomes resistance to ceritinib by inhibiting P-gp function and induces apoptosis through mitochondrial pathway in ceritinib-resistant
Journal
Chemico-biological interactions
Toll-like Receptor 4 Deficiency Aggravates Airway Hyperresponsiveness and Inflammation by Impairing Neutrophil Apoptosis in a Toluene Diisocyanate-Induced Murine Asthma Model
Journal
Allergy Asthma Immunol Res
FoxM1 Directs STAT3 Expression Essential for Human Endometrial Stromal Decidualization
Journal
Scientific Reports
Melatonin alleviates oxidative stress-induced injury to nucleus pulposus-derived mesenchymal stem cells through activating PI3K/Akt pathway - PMC
Journal
Journal of orthopaedic translation
The role and mechanism of action of RNF186 in colorectal cancer through negative regulation of NF-κB
Low doses of niclosamide and quinacrine combination yields synergistic effect in melanoma via activating autophagy-mediated p53-dependent apoptosis
Journal
Translational oncology
PDCD10 promotes proliferation, migration, and invasion of osteosarcoma by inhibiting apoptosis and activating EMT pathway
CircRNA254 functions as the miR-375 sponge to inhibit coelomocyte apoptosis via targeting BAG2 in V. splendidus-challenged Apostichopus japonicus
Journal
Fish & shellfish immunology
Species
Apostichopus japonicus
Polysaccharide of Atractylodes macrocephala Koidz (PAMK) protects against DEHP-induced apoptosis in grass carp hepatocytes
Journal
Fish & shellfish immunology
Species
Ctenopharyngodon idellus
Fraxetin inhibits interleukin-1β-induced apoptosis, inflammation, and matrix degradation in chondrocytes and protects rat cartilage in vivo
Protective effects of dietary icariin on lipopolysaccharide-induced acute oxidative stress and hepatopancreas injury in Chinese mitten crab, Eriocheir sinensis
Journal
Comp Biochem Physiol C Toxicol Pharmacol
Species
Eriocheir sinensis
Plin3 protects against alcoholic liver injury by facilitating lipid export from the endoplasmic reticulum
Journal
Journal of cellular biochemistry
Histone Methyltransferase SETDB1 Promotes the Progression of Colorectal Cancer by Inhibiting the Expression of TP53.
Dimethoxytolyl propylresorcinol induces apoptosis and mitophagy in human leukemia cells through the PI3K/AKT pathway - PMC
Species
Dianella ensifolia,Homo sapiens
Kinetin inhibits hepatic stellate cell activation and induces apoptosis via interactions with the TGF-1/Smad signaling pathway
Journal
Toxicology and applied pharmacology
Up-regulation of PUMA caused the activation of p53 phosphorylation and acetylation, enhancing the interaction between PUMA and Bcl-X and mediating arsenic
Journal
Toxicol Appl Pharmacol
Cadmium induced inflammation and apoptosis of porcine epididymis via activating RAF1/MEK/ERK and NF-κB pathways
Journal
Toxicol Appl Pharmacol
Integrin α5 mediates intrinsic cisplatin resistance in three-dimensional nasopharyngeal carcinoma spheroids via the inhibition of phosphorylated ERK /caspase-3 induced apoptosis
Ginsenoside 24-OH-PD from red ginseng inhibits acute T-lymphocytic leukaemia by activating the mitochondrial pathway - PMC
Inhibition of miR-423-5p exerts neuroprotective effects in an experimental rat model of cerebral ischemia/reperfusion injury
Maresin 1 Inhibits Epithelial-to-Mesenchymal Transition in Vitro and Attenuates Bleomycin Induced Lung Fibrosis in Vivo
Epigallocatechin-3-gallate suppresses alveolar epithelial cell apoptosis in seawater aspiration-induced acute lung injury via inhibiting STAT1-caspase-3/p21 associated pathway
Journal
Molecular medicine reports
Acetyl zingerone ameliorates osteoarthritis by inhibiting chondrocyte programmed cell death - PMC
Journal
Molecular medicine reports
Atp7b deficiency induces zebrafish eye developmental defects.
Iron overload enhances TBI-induced cardiac dysfunction by promoting ferroptosis and cardiac inflammation
Journal
Biochemical and biophysical research communications
Itraconazole halts hepatocellular carcinoma progression by modulating sonic hedgehog signaling in rats: A novel therapeutic approach
Journal
Pathology, research and practice
Identification and verification of HCAR3 and INSL5 as new potential therapeutic targets of colorectal cancer
Journal
World J Surg Oncol
The Aqueous Leaf Extract of M. oleifera Inhibits PEDV Replication through Suppressing Oxidative Stress-Mediated Apoptosis
Journal
Animals : an open access journal from MDPI
Species
African green monkey
Rectangular method: a modified technique for sampling the ischemic border zone in a rat model of transient middle cerebral artery occlusion - PMC
Journal
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
Trastuzumab-induced human cardiomyocyte damage through the Notch2/JAK2/STAT3 pathway - PMC
Journal
Clinics (Sao Paulo, Brazil)
Schisantherin A improves learning and memory abilities partly through regulating the Nrf2/Keap1/ARE signaling pathway in chronic fatigue mice
Bone marrow mesenchymal stem cell derived exosomal miR-455-5p protects against spinal cord ischemia reperfusion injury
Mitochondrial dysfunction in follicles is associated with broodiness in Zhedong white goose
Journal
Animal reproduction science
Stanniocalcin-1 protects bovine intestinal epithelial cells from oxidative stress-induced damage
Journal
Journal of veterinary science