Maize smart-canopy architecture enhances yield at high densities
Tumor cell vaccine combined with Newcastle disease virus promote immunotherapy of lung cancer
Journal
Journal of medical virology
Eukaryotic AlaX provides multiple checkpoints for quality and quantity of aminoacyl-tRNAs in translation
Journal
Nucleic acids research
Species
Mus musculus,Oryctolagus cuniculus
p66Shc Contributes to Liver Fibrosis through the Regulation of Mitochondrial Reactive Oxygen Species.
m6A methylation-induced NR1D1 ablation disrupts the HSC circadian clock and promotes hepatic fibrosis
Journal
Pharmacological research
Endothelial cell pyroptosis plays an important role in Kawasaki disease via HMGB1/RAGE/cathespin B signaling pathway and NLRP3 inflammasome activation
Journal
Cell death & disease
Alternative polyadenylation trans-factor FIP1 exacerbates UUO/IRI-induced kidney injury and contributes to AKI-CKD transition via ROS-NLRP3 axis
Nicotine promotes atherosclerosis via ROS-NLRP3-mediated endothelial cell pyroptosis
Journal
Cell Death and Disease
Deficiency of the microglial Hv1 proton channel attenuates neuronal pyroptosis and inhibits inflammatory reaction after spinal cord injury
Journal
J Neuroinflammation
ASC specks exacerbate α-synuclein pathology via amplifying NLRP3 inflammasome activities - PMC
Journal
Journal of neuroinflammation
Elamipretide alleviates pyroptosis in traumatically injured spinal cord by inhibiting cPLA2-induced lysosomal membrane permeabilization - PMC
Journal
Journal of neuroinflammation
Weizmannia coagulans BCF-01: a novel gastrogenic probiotic for Helicobacter pylori infection control - PMC
The central role of a two-way positive feedback pathway in molecular targeted therapies-mediated pyroptosis in anaplastic thyroid cancer
Journal
Clinical and translational medicine
IL-17A-mediated mitochondrial dysfunction induces pyroptosis in colorectal cancer cells and promotes CD8+T-cell tumour infiltration - PMC
Journal
Journal of translational medicine
Ezrin inhibition alleviates oxidative stress and pyroptosis via regulating TRPML1-calcineurin axis mediated enhancement of autophagy in spinal cord injury
Journal
Free radical biology & medicine
Oyster (Crassostrea gigas) ferritin relieves lead-induced liver oxidative damage via regulating the mitophagy
Journal
International journal of biological macromolecules
Alleviative effect of poly--hydroxybutyrate on lipopolysaccharide-induced oxidative stress, inflammation and cell apoptosis in Cyprinus carpio
Journal
International journal of biological macromolecules
Targeting antioxidant factor Nrf2 by raffinose ameliorates lipid dysmetabolism-induced pyroptosis, inflammation and fibrosis in NAFLD
Journal
Phytomedicine : international journal of phytotherapy and phytopharmacology
Biochanin A Ameliorates Nephropathy in High-Fat Diet/Streptozotocin-Induced Diabetic Rats: Effects on NF-kB/NLRP3 Axis, Pyroptosis, and Fibrosis - PMC
Journal
Antioxidants (Basel, Switzerland)
Compound Danshen Dripping Pill inhibits doxorubicin or isoproterenol-induced cardiotoxicity
Journal
Biomed Pharmacother
Melatonin alleviates doxorubicin-induced cardiotoxicity via inhibiting oxidative stress, pyroptosis and apoptosis by activating Sirt1/Nrf2 pathway
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Carnosine alleviates cisplatin-induced acute kidney injury by targeting Caspase-1 regulated pyroptosis
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Kanglexin, a novel anthraquinone compound, protects against myocardial ischemic injury in mice by suppressing NLRP3 and pyroptosis
Journal
Acta Pharmacologica Sinica
Protective effect and mechanism of baicalin on lung inflammatory injury in BALB/cJ mice induced by PM2. 5
Journal
Ecotoxicology and environmental safety
3, 4-benzopyrene aggravates myocardial ischemiareperfusion injury-induced pyroptosis through inhibition of autophagy-dependent NLRP3 degradation
Journal
Ecotoxicology and environmental safety
Species
Mus musculus, Rattus norvegicus
Mitophagy protects against silver nanoparticleinduced hepatotoxicity by inhibiting mitochondrial ROS and the NLRP3 inflammasome
Journal
Ecotoxicology and environmental safety
FK866 attenuates sepsis-induced acute lung injury through c-jun-N-terminal kinase (JNK)-dependent autophagy
Biochanin A alleviates unilateral ureteral obstruction-induced renal interstitial fibrosis and inflammation by inhibiting the TGF-1/Smad2/3 and NF-kB/NLRP3 signaling axis in mice
Anti-inflammatory activity of carvacrol protects the heart from lipopolysaccharide-induced cardiac dysfunction by inhibiting pyroptosis via NLRP3/Caspase1/Gasdermin …
Phloretin ameliorates hyperuricemia-induced chronic renal dysfunction through inhibiting NLRP3 inflammasome and uric acid reabsorption
Journal
Phytomedicine : international journal of phytotherapy and phytopharmacology
Species
Homo sapiens, Mus musculus
Treatment of ulcerative colitis with Wu-Mei-Wan by inhibiting intestinal inflammatory response and repairing damaged intestinal mucosa
Journal
Phytomedicine : international journal of phytotherapy and phytopharmacology
Xuanfei Baidu Decoction suppresses complement overactivation and ameliorates IgG immune complex-induced acute lung injury by inhibiting JAK2/STAT3/SOCS3 and NF-κB signaling pathway - PMC
Journal
Phytomedicine : international journal of phytotherapy and phytopharmacology
Inhibition of Sema4D attenuates pressure overload-induced pathological myocardial hypertrophy via the MAPK/NF-B/NLRP3 pathways
Journal
Biochimica et biophysica acta. Molecular basis of disease
Polyphyllin VI Induces Caspase-1-Mediated Pyroptosis via the Induction of ROS/NF-κB/NLRP3/GSDMD Signal Axis in Non-Small Cell Lung Cancer
Foot-and-Mouth Disease Virus Induces Porcine Gasdermin E-Mediated Pyroptosis through the Protease Activity of 3Cpro
Journal
Journal of virology
Liraglutide, a TFEB-Mediated Autophagy Agonist, Promotes the Viability of Random-Pattern Skin Flaps
Journal
Oxid Med Cell Longev
Exenatide improves randompattern skin flap survival via TFE3 mediated autophagy augment
Journal
Journal of cellular physiology
Pinocembrin alleviates pyroptosis and apoptosis through ROS elimination in random skin flaps via activation of SIRT3
Journal
Phytotherapy research : PTR
Replacing dietary sodium selenite with biogenic selenium nanoparticles improves the growth performance and gut health of early-weaned piglets
Extracellular vesicles isolated from hyperuricemia patients might aggravate airway inflammation of COPD via senescence-associated pathway - PMC
Journal
Journal of inflammation (London, England)
Toll-like receptor 4 mediates methamphetamine-induced neuroinflammation through Caspase-11 signaling pathway in astrocytes
Journal
Frontiers in Molecular Neuroscience
The Role of the FOXO1/β 2-AR/p-NF-κB p65 Pathway in the Development of Endometrial Stromal Cells in Pregnant Mice under Restraint Stress
GLUT1 promotes NLRP3 inflammasome activation of airway epithelium in lipopolysaccharide-induced acute lung injury
Journal
The American journal of pathology
STUB1 is acetylated by KAT5 and alleviates myocardial ischemia-reperfusion injury through LATS2-YAP--catenin axis
Journal
Communications biology
Species
Homo sapiens,Mus musculus
T-2 Toxin Caused Mice Testicular Inflammation Injury via ROS-Mediated NLRP3 Inflammasome Activation
Journal
Journal of agricultural and food chemistry
Peptide-TLR7/8a-Coordinated DNA Vaccines Elicit Enhanced Immune Responses against Infectious Diseases
Journal
ACS biomaterials science & engineering
Early Microcystin-LR exposure-linked inflammasome activation in mice causes development of fatty liver disease and insulin resistance
Journal
Environ Toxicol Pharmacol
Perillyl Alcohol Attenuates NLRP3 Inflammasome Activation and Rescues Dopaminergic Neurons in Experimental In Vitro and In Vivo Models of Parkinson's Disease
Sodium tanshinone IIA sulfonate attenuates sepsis-associated brain injury via inhibiting NOD-like receptor 3/caspase-1/gasdermin D-mediated pyroptosis
Journal
International immunopharmacology
Fibroblast growth factor 10 protects against particulate matter-induced lung injury by inhibiting oxidative stress-mediated pyroptosis via the PI3K/Akt/Nrf2 signaling
Journal
International immunopharmacology
3, 4-Benzopyrene (Bap) aggravated abdominal aortic aneurysm formation by targeting pyroptosis in smooth muscle cells through ET-1 mediated NLRP3
Journal
International immunopharmacology
3, 4-Benzopyrene (Bap) aggravated abdominal aortic aneurysm formation by targeting pyroptosis in smooth muscle cells through ET-1 mediated NLRP3
Journal
International immunopharmacology
Fucoxanthin alleviated atherosclerosis by regulating PI3K/AKT and TLR4/NFκB mediated pyroptosis in endothelial cells
Journal
International immunopharmacology
Glycyrrhizin protects against particulate matter-induced lung injury via regulation of endoplasmic reticulum stress and NLRP3 inflammasome-mediated pyroptosis …
Journal
International immunopharmacology
Nuciferine alleviates intestinal inflammation by inhibiting MAPK/NF-κB and NLRP3/Caspase 1 pathways in vivo and in vitro
Journal
International immunopharmacology
Overexpression of NLRP12 enhances macrophage immune response and alleviates herpes simplex keratitis - PMC
Journal
Frontiers in cellular and infection microbiology
Protein and metabolic profiles of tyrosine kinase inhibitors co-resistant liver cancer cells - PMC
Journal
Frontiers in pharmacology
The effect of isovitexin on lipopolysaccharide-induced renal injury and inflammation by induction of protective autophagy
Journal
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Copper induces microglia-mediated neuroinflammation through ROS/NF-κB pathway and mitophagy disorder
Journal
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Fisetin-loaded chitosan nanoparticles ameliorate pilocarpine-induced temporal lobe epilepsy and associated neurobehavioral alterations in mice: Role of ROS/TNF-
Journal
Nanomedicine : nanotechnology, biology, and medicine
Alternanthera brasiliana L. extract alleviates carbon tetrachloride-induced liver injury and fibrotic changes in mice: Role of matrix metalloproteinases and TGF-β/Smad …
Journal
Journal of ethnopharmacology
Tongxinluo attenuates atherosclerosis by inhibiting ROS/NLRP3/caspase-1-mediated endothelial cell pyroptosis
Journal
Journal of ethnopharmacology
S1P/S1PR2 promote pancreatic stellate cell activation and pancreatic fibrosis in chronic pancreatitis by regulating autophagy and the NLRP3 inflammasome
Journal
Chemico-biological interactions
Paeoniflorin attenuates particulate matter-induced acute lung injury by inhibiting oxidative stress and NLRP3 inflammasome-mediated pyroptosis through activation of
Journal
Chemico-biological interactions
Naringenin reduces oxidative stress and necroptosis, apoptosis, and pyroptosis in random-pattern skin flaps by enhancing autophagy
Journal
European journal of pharmacology
Long Noncoding RNA AC078850.1 Induces NLRP3 Inflammasome-Mediated Pyroptosis in Atherosclerosis by Upregulating ITGB2 Transcription via Transcription Factor HIF-1α - PMC
Human umbilical cord mesenchymal stem cells repair endothelial injury and dysfunction by regulating NLRP3 to inhibit endothelial cell pyroptosis in Kawasaki
Species
Homo sapiens,Mus musculus
Melatonin Attenuates Neuroinflammation by Down-Regulating NLRP3 Inflammasome via a SIRT1-Dependent Pathway in MPTP-Induced Models of Parkinson's Disease
Protective Effect of Crocin on Immune Checkpoint Inhibitors-Related Myocarditis Through Inhibiting NLRP3 Mediated Pyroptosis in Cardiomyocytes via NF-κB Pathway
Journal
Journal of inflammation research
Urban Particulate Matter Triggers Meibomian Gland Dysfunction - PMC
Journal
Investigative ophthalmology & visual science
NLRP3 inflammasome activation by estrogen promotes the progression of human endometrial cancer.
Journal
OncoTargets and therapy
A novel cysteine protease inhibitor in Baylisascaris schroederi migratory larvae regulates inflammasome activation through the TLR4-ROS-NLRP3 pathway - PMC
Journal
Parasites & vectors
Apelin ameliorates sepsis-induced myocardial dysfunction via inhibition of NLRP3-mediated pyroptosis of cardiomyocytes - PMC
Inhibition of miR-423-5p exerts neuroprotective effects in an experimental rat model of cerebral ischemia/reperfusion injury
Conditioned medium of human menstrual blood-derived endometrial stem cells protects against cell inflammation and apoptosis of Npc1KO N2a cells
Journal
Metabolic brain disease
Inflammation plays a critical role in damage to the bronchiolar epithelium induced by Trueperella pyogenes in vitro and in vivo
Journal
Infection and immunity
Exogenous Spermidine Alleviates Diabetic Myocardial Fibrosis Via Suppressing Inflammation and Pyroptosis in db/db Mice - PMC
Journal
Balkan medical journal
Macrophage-derived exosomal miRNA-141 triggers endothelial cell pyroptosis by targeting NLRP3 to accelerate sepsis progression - PMC
Journal
International journal of immunopathology and pharmacology
Hydrogen sulfide mitigates ox-LDL-induced NLRP3/caspase-1/GSDMD dependent macrophage pyroptosis by S-sulfhydrating caspase-1 - PMC
Journal
Molecular medicine reports
Dicoumarol attenuates NLRP3 inflammasome activation to inhibit inflammation and fibrosis in knee osteoarthritis - PMC
Journal
Molecular medicine reports
Electroacupuncture ameliorates knee osteoarthritis in rats via inhibiting NLRP3 inflammasome and reducing pyroptosis
Melatonin alleviates cigarette smoke-induced endothelial cell pyroptosis through inhibiting ROS/NLRP3 axis
Journal
Biochemical and biophysical research communications
Macrophage pyroptosis is mediated by immunoproteasome subunit β5i (LMP7) in abdominal aortic aneurysm
Journal
Biochem Biophys Res Commun
FGF5 protects heart from sepsis injury by attenuating cardiomyocyte pyroptosis through inhibiting CaMKII/NFκB signaling
Journal
Biochemical and biophysical research communications
FGF5 alleviated acute lung injury via AKT signal pathway in endothelial cells - PMC
Journal
Biochemical and biophysical research communications
CD147 Aggravated Inflammatory Bowel Disease by Triggering NF-κB-Mediated Pyroptosis
HBx-induced PLA2R overexpression mediates podocyte pyroptosis through the ROS-NLRP3 signaling pathway - PMC
Identification of an LDLR variant in a Chinese familial hypercholesterolemia and its relation to ROS/NLRP3-Mediated pyroptosis in hepatic cells - PMC
Journal
Journal of geriatric cardiology : JGC
Protopine-Type Alkaloids Alleviate Lipopolysaccharide-Induced Intestinal Inflammation and Modulate the Gut Microbiota in Mice - PMC
Journal
Animals : an open access journal from MDPI
Knockdown of ELF4 aggravates renal injury in ischemia/reperfusion mice through promotion of pyroptosis, inflammation, oxidative stress, and endoplasmic reticulum stress - PMC
Journal
BMC molecular and cell biology
Species
Homo sapiens, Mus musculus
Interleukin-18 expression in oral squamous cell carcinoma: its role in tumor cell migration and invasion, and growth of tumor cell xenografts.
Hepatitis B virus X mediates podocyte pyroptosis by regulating the ROS/NLRP3 signaling pathway in hepatitis B virus-associated glomerulonephritis
Journal
Iranian journal of basic medical sciences
Tanshinone IIA alleviates early brain injury after subarachnoid hemorrhage in rats by inhibiting the activation of NF-B/NLRP3 inflammasome
Journal
Biological & pharmaceutical bulletin
Long-term exercise training inhibits inflammation by suppressing hippocampal NLRP3 in APP/PS1 mice
Journal
Sports medicine and health science
Gasdermin D-mediated pyroptosis is regulated by AMPK-mediated phosphorylation in tumor cells - PMC
Journal
Cell death & disease
Low-dose arsenite causes overexpression of EGF, TGFα, and HSP90 through Trx1-TXNIP-NLRP3 axis mediated signaling pathways in the human bladder …
Journal
Ecotoxicol Environ Saf