Aspartoacylase suppresses prostate cancer progression by blocking LYN activation - PMC
Journal
Military Medical Research
CDK7 inhibitor THZ1 enhances antiPD-1 therapy efficacy via the p38α/MYC/PD-L1 signaling in non-small cell lung cancer
Unspliced XBP1 Counteracts -Catenin to Inhibit Vascular Calcification
Journal
Circulation Research
Red Light-Triggered Anti-Angiogenic and Photodynamic Combination Therapy of Age-Related Macular Degeneration - PMC
Journal
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Regulation of an osteon-like concentric microgrooved surface on osteogenesis and osteoclastogenesis.
Delivery of hydroxycamptothecin via sonoporation: An effective therapy for liver fibrosis
Journal
Journal of controlled release : official journal of the Controlled Release Society
Microarray analysis of gene expression differences in microglia after exposure to graphene quantum dots
Journal
The Science of the total environment
Value added immunoregulatory polysaccharides of Hericium erinaceus and their effect on the gut microbiota
Urate-Lowering Therapy Inhibits Thoracic Aortic Aneurysm and Dissection Formation in Mice
Journal
Arteriosclerosis, thrombosis, and vascular biology
AMPK-autophagy-mediated inhibition of microRNA-30a-5p alleviates morphine tolerance via SOCS3-dependent neuroinflammation suppression
Journal
Journal of neuroinflammation
Cerium oxide nanoparticles-carrying human umbilical cord mesenchymal stem cells counteract oxidative damage and facilitate tendon regeneration - PMC
Journal
Journal of nanobiotechnology
Heme Oxygenase-1 Regulates Ferrous Iron and Foxo1 in Control of Hepatic Gluconeogenesis
Environment relevant exposure of perfluorooctanoic acid accelerates the growth of hepatocellular carcinoma cells through mammalian target of rapamycin (mTOR)
Journal
Environmental pollution (Barking, Essex : 1987)
Flavonoid-rich sesame leaf extract-mediated synthesis of nanozymes: Extraction optimization, chemical composition identification and bioactivity evaluation
IP-10 Promotes Blood-Brain Barrier Damage by Inducing Tumor Necrosis Factor Alpha Production in Japanese Encephalitis
Journal
Frontiers in Immunology
Extracellular matrix derived from Whartons Jelly-derived mesenchymal stem cells promotes angiogenesis via integrin V3/c-Myc/P300/VEGF - PMC
Journal
Stem cell research & therapy
Cell-specific IL-1R1 regulates the regional heterogeneity of microglial displacement of GABAergic synapses and motor learning ability - PMC
Journal
Cellular and molecular life sciences : CMLS
Modeling the Effects of Cypermethrin Toxicity on Ovalbumin-Induced Allergic Pneumonitis Rats: Macrophage Phenotype Differentiation and p38/STAT6 Signaling Are Candidate Targets of Pirfenidone Treatment - PMC
Benzoylaconitine: A promising ACE2-targeted agonist for enhancing cardiac function in heart failure
Journal
Free radical biology & medicine
Liver X receptor agonists exert antitumor effects against hepatocellular carcinoma via inducing REPS2 expression
Journal
Acta pharmacologica Sinica
Heparanase induces necroptosis of microvascular endothelial cells to promote the metastasis of hepatocellular carcinoma
Design, synthesis, and SAR study of novel flavone 1, 2, 4-oxadiazole derivatives with anti-inflammatory activities for the treatment of Parkinson's disease
Journal
European journal of medicinal chemistry
JNK molecule is a toxic target for IPEC-J2 cell barrier damage induced by T-2 toxin
Journal
Ecotoxicology and environmental safety
Short-chain fatty acids mitigate Methamphetamine-induced hepatic injuries in a Sigma-1 receptor-dependent manner
Journal
Ecotoxicology and environmental safety
Glabridin Ameliorates Alcohol-Caused Liver Damage by Reducing Oxidative Stress and Inflammation via p38 MAPK/Nrf2/NF-B Pathway - PMC
Polysaccharides from Hericium erinaceus Fruiting Bodies: Structural Characterization, Immunomodulatory Activity and Mechanism - PMC
Species
Homo sapiens, Mus musculus
Daucosterol Alleviates Alcohol-Induced Hepatic Injury and Inflammation through P38/NF-κB/NLRP3 Inflammasome Pathway - PMC
Effects and Mechanisms of Rhus chinensis Mill. Fruits on Suppressing RANKL-Induced Osteoclastogenesis by Network Pharmacology and Validation in RAW264.7 Cells
Schisantherin A ameliorates liver fibrosis through TGF-β1mediated activation of TAK1/MAPK and NF-κB pathways in vitro and in vivo
Berberine improves ovulation and endometrial receptivity in polycystic ovary syndrome
Improved colonic inflammation by nervonic acid via inhibition of NF-κB signaling pathway of DSS-induced colitis mice
Journal
Phytomedicine : international journal of phytotherapy and phytopharmacology
In vivo hepatoprotective activity and the underlying mechanism of chebulinic acid from Terminalia chebula fruit
Journal
Phytomedicine : international journal of phytotherapy and phytopharmacology
Royal jelly from different floral sources possesses distinct wound-healing mechanisms and ingredient profiles
Molecular mechanisms of selenium-biofortified soybean protein and polyphenol conjugates in protecting mouse skin damaged by UV-B
The preventive effect and underlying mechanism of Rhus chinensis Mill. fruits on dextran sulphate sodium-induced ulcerative colitis in mice
Effects of Sarcoptes scabiei Translationally Controlled Tumor Protein (TCTP) on Histamine Release and Degranulation of KU812 Cells - PMC
Journal
International journal of molecular sciences
Diclofenac Sensitizes Signet Ring Cell Gastric Carcinoma Cells to Cisplatin by Activating Autophagy and Inhibition of Survival Signal Pathways - PMC
Journal
International journal of molecular sciences
The Extracts of Dendrobium Alleviate Dry Eye Disease in Rat Model by Regulating Aquaporin Expression and MAPKs/NF-κB Signalling - PMC
Journal
International journal of molecular sciences
Studying Antifatigue Mechanism of Tyr-Pro-Leu-Pro in Exercise Mice Using Label-Free Proteomics
Journal
Journal of agricultural and food chemistry
Species
Mus musculus,Other
Therapeutic effect of fenofibrate for non-alcoholic steatohepatitis in mouse models is dependent on regime design - PMC
Journal
Frontiers in pharmacology
Docosahexaenoic Acid Coordinating with Sodium Selenite Promotes Paraptosis in Colorectal Cancer Cells by Disrupting the Redox Homeostasis and Activating the MAPK Pathway - PMC
Characterizations and the Mechanism Underlying Osteogenic Activity of Peptides from Enzymatic Hydrolysates of Stichopus japonicus
Biotransformation of 18β-Glycyrrhetinic Acid by Human Intestinal Fungus Aspergillus niger RG13B1 and the Potential Anti-Inflammatory Mechanism of Its Metabolites
Journal
Journal of agricultural and food chemistry
Myricetin Suppresses Ovarian Cancer In Vitro by Activating the p38/Sapla Signaling Pathway and Suppressing Intracellular Oxidative Stress
Journal
Frontiers in oncology
Imperatorin reduces the inflammatory response of atherosclerosis by regulating MAPKs signaling pathway in vivo and in vitro
Journal
International Immunopharmacology
Dexmedetomidine attenuates hepatic ischemia-reperfusion injury-induced apoptosis via reducing oxidative stress and endoplasmic reticulum stress
Journal
International immunopharmacology
pNaktide mitigates inflammation-induced neuronal damage and behavioral deficits through the oxidative stress pathway
Journal
International immunopharmacology
Network pharmacology-based strategy to investigate pharmacological mechanisms of Andrographolide for treatment of vascular cognitive impairment
Journal
International immunopharmacology
Knockdown of EIF4G1 in NSCLC induces CXCL8 secretion - PMC
Journal
Frontiers in pharmacology
Non-Esterified Fatty Acid Induces ER Stress-Mediated Apoptosis via ROS/MAPK Signaling Pathway in Bovine Mammary Epithelial Cells - PMC
Phosphorylated chitosan hydrogels inducing osteogenic differentiation of osteoblasts via JNK and p38 signaling pathways
Journal
ACS biomaterials science & engineering
Discovery of novel dihydropyrazole-stilbene derivatives for ameliorating heart failure through modulation of p38/NF-kB signaling pathway
Journal
Bioorganic chemistry
Anneslea fragrans Wall. ameliorates ulcerative colitis via inhibiting NF-κB and MAPK activation and mediating intestinal barrier integrity
In vitro and in vivo relaxation and anti-inflammation of natural flavonoids from Elaeagnus pungens leaf via L-type calcium channel and targeting MAPK signal pathway
In vitro and in vivo anti-inflammatory effects of different extracts from Epigynum auritum through down-regulation of NF-κB and MAPK signaling pathways
Discovery of 4-((3, 4-dichlorophenyl) amino)-2-methylquinolin-6-ol derivatives as EGFR and HDAC dual inhibitors
Journal
European journal of pharmacology
Potential Anti-Gout Properties of Wuwei Shexiang Pills Based on Network Pharmacology and Pharmacological Verification
Journal
Journal of ethnopharmacology
Cathepsin C Interacts with TNF-/p38 MAPK Signaling Pathway to Promote Proliferation and Metastasis in Hepatocellular Carcinoma.
Journal
Cancer Research and Treatment
Discovery of a novel class of benzimidazoles as highly effective agonists of bone morphogenetic protein (BMP) receptor signaling - PMC
Journal
Scientific reports
COX-2 is required to mediate crosstalk of ROS-dependent activation of MAPK/NF-κB signaling with pro-inflammatory response and defense-related NO enhancement during challenge of macrophage-like cell line with Giardia duodenalis
Journal
PLoS neglected tropical diseases
MicroRNA-532-3p Regulates Pro-Inflammatory Human THP-1 Macrophages by Targeting ASK1/p38 MAPK Pathway
Vascular Adventitial Fibroblasts-Derived FGF10 Promotes Vascular Smooth Muscle Cells Proliferation and Migration in vitro and the Neointima Formation in vivo
Legumain Inhibitor Prevents Breast Cancer Bone Metastasis by Attenuating Osteoclast Differentiation and Function
Species
Homo sapiens, Mus musculus
Legumain Inhibitor Prevents Breast Cancer Bone Metastasis by Attenuating Osteoclast Differentiation and Function
Species
Homo sapiens, Mus musculus
Zinc alleviates thermal stress-induced damage to the integrity and barrier function of cultured chicken embryonic primary jejunal epithelial cells via the MAPK and PI3K/AKT/mTOR signaling pathways - PMC
Knockdown of GBP1 inhibits BCG-induced apoptosis in macrophage RAW 264.7 cells via p38/JNK pathway
Network and Experimental Pharmacology to Decode the Action of Wendan Decoction Against Generalized Anxiety Disorder - PMC
Journal
Drug design, development and therapy
Network Pharmacology Analysis and Experimental Validation to Investigate the Mechanism of Total Flavonoids of Rhizoma Drynariae in Treating Rheumatoid Arthritis - PMC
Journal
Drug design, development and therapy
Suppression of mir-1505p attenuates the anti-inflammatory effect of glucocorticoids in mice with ulcerative colitis
Journal
Molecular immunology
TRPM4 mRNA stabilization by METTL3-mediated m6A modification promotes calcific aortic valve inflammation - PMC
Oridonin Attenuates Thioacetamide-Induced Osteoclastogenesis Through MAPK/NF-κB Pathway and Thioacetamide-Inhibited Osteoblastogenesis Through …
Journal
Calcified tissue international
Species
Mus musculus,Rattus norvegicus
Cyanidin attenuates IL-17A cytokine signaling mediated monocyte migration and differentiation into mature osteoclasts in rheumatoid arthritis
Dihydromyricetin attenuates cisplatin-induced acute kidney injury by reducing oxidative stress, inflammation and ferroptosis
Journal
Toxicology and Applied Pharmacology
Preparation, characterization and pharmacodynamic study on deep second degree burns of total flavonoids composite phospholipids liposome of Oxytropis falcata Bunge
Journal
Drug Dev Ind Pharm
The Anti-Apoptotic Role of COX-2 during In Vitro Infection of Human Intestinal Cell Line by Giardia duodenalis and The Potential Regulators
Journal
Infection and immunity
The Effects of Inorganic Phosphorus Levels on Phosphorus Utilization, Local Bone-Derived Regulators, and BMP/MAPK Pathway in Primary Cultured Osteoblasts of Broiler Chicks
Journal
Frontiers in veterinary science
Long noncoding RNA LOC100911498 is a novel regulator of neuropathic pain in rats
Journal
Brain and behavior
Role of TLR4-p38 MAPK-Hsp27 signal pathway in LPS-induced pulmonary epithelial hyperpermeability.
Journal
BMC pulmonary medicine
Deletion of the crp gene affects the virulence and the activation of the NF-B and MAPK signaling pathways in PK-15 and iPAM cells derived from G. parasuis serovar 5
The polysaccharide from Camellia oleifera fruit shell enhances immune responses via activating MAPKs and NF-κB signaling pathways in RAW264.7 macrophages - PMC
Journal
Food & nutrition research
FGF19 promotes cell autophagy and cisplatin chemoresistance by activating MAPK signaling in ovarian cancer - PMC
Gas chromatography (GC) fingerprinting and immunomodulatory activity of polysaccharide from the rhizome of Menispermum dauricum DC - PMC
The Role and Mechanism of Nicotinamide Riboside in Oxidative Damage and a Fibrosis Model of Trabecular Meshwork Cells - PMC
Journal
Translational vision science & technology
Inhibited Expression of NLRP12 Promotes the Development of Triple-Negative Breast Cancer by Activating the NF-B Pathway
Journal
Cell biochemistry and biophysics
Immunoenhancement activity of Bletilla striata polysaccharide through MAPK and NF-κB signalling pathways in vivo and in vitro
In vitro and in silico analysis of ‘Taikong blue lavender essential oil in LPS-induced HaCaT cells and RAW264.7 murine macrophages - PMC
Journal
BMC complementary medicine and therapies
Species
Homo sapiens, Mus musculus
The inhibitory impact of Schisandrin on inflammation and oxidative stress alleviates LPSinduced acute kidney injury
Journal
Biotechnology and applied biochemistry
ENPP1 deletion causes mouse osteoporosis via the MKK3/p38 MAPK/PCNA signaling pathway - PMC
Journal
Journal of orthopaedic surgery and research
Exploring the Mechanism of Realgar against Esophageal Cancer Based on Ferroptosis Induced by ROS-ASK1-p38 MAPK Signaling Pathway - PMC
Journal
Evidence-based complementary and alternative medicine : eCAM
Protective Effects of Anwulignan against HCl/Ethanol-Induced Acute Gastric Ulcer in Mice
Journal
Evid Based Complement Alternat Med
Q-switched 1064-nm dymium-doped yttrium aluminum garnet laser irradiation induces skin collagen synthesis by stimulating MAPKs pathway.
Journal
Lasers in medical science
Schisandrin B inhibits α-melanocyte-stimulating hormone-induced melanogenesis in B16F10 cells via downregulation of MAPK and CREB signaling pathways
Journal
Bioscience, biotechnology, and biochemistry
In vivo protective effects of 6-gingerol in cerebral ischemia involve preservation of antioxidant defenses and activation of anti-apoptotic pathways - PMC
Journal
Biomedical reports
Elucidating the Mechanism of Buyanghuanwu Decoction Acting on Pulmonary Fibrosis Based on Network Pharmacology and Animal Studies - PMC
Journal
Combinatorial chemistry & high throughput screening
Licorice zinc suppresses melanogenesis via inhibiting the activation of P38MAPK and JNK signaling pathway in C57BL/6J mice skin - PMC
Journal
Acta cirurgica brasileira
The in vitro mechanism of Vaspinregulates the proliferation and steroidogenesis of rat lutein cells
Identification of circulating T-cell immunoglobulin and mucin domain 4 as a potential biomarker for coronary heart disease - PMC
Combining an in silico approach with an animal experiment to investigate the protective effect of troxerutin for treating acute lung injury
Journal
BMC complementary and alternative medicine