GATA3 mediates doxorubicin resistance by inhibiting CYB5R2-catalyzed iron reduction in breast cancer cells
Journal
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy
O-GlcNAcylation Facilitates
the Interaction between Keratin 18 and Isocitrate Dehydrogenases and
Potentially Influencing Cholangiocarcinoma Progression - PMC
Journal
ACS central science
Pathogenesis-adaptive polydopamine nanosystem for sequential therapy of ischemic stroke - PMC
Journal
Nature communications
Discovery of the major 15-30 nt mammalian small RNAs, their biogenesis and function - PMC
Journal
Nature communications
TAOK3 Facilitates Esophageal Squamous Cell Carcinoma Progression and Cisplatin Resistance Through Augmenting Autophagy Mediated by IRGM - PMC
Journal
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
A/(H1N1) pdm09 NS1 promotes viral replication by enhancing autophagy through hijacking the IAV negative regulatory factor LRPPRC
N6-methyladenosine demethylase FTO enhances chemo-resistance in colorectal cancer through SIVA1-mediated apoptosis
Journal
Molecular therapy : the journal of the American Society of Gene Therapy
LT-171-861, a novel FLT3 inhibitor, shows excellent preclinical efficacy for the treatment of FLT3 mutant acute myeloid leukemia
Species
Homo sapiens, Mus musculus
Inhibition of acylglycerol kinase sensitizes DLBCL to venetoclax via upregulation of FOXO1-mediated BCL-2 expression - PMC
Ignored role of polyphenol in boosting reactive oxygen species generation for polyphenol/chemodynamic combination therapy - PMC
Journal
Materials today. Bio
Mucoadhesive Carrier-Mediated Oral Co-delivery of Bcl2 Inhibitors Improves Gastric Cancer Treatment
Journal
ACS applied materials & interfaces
Tryptophan deficiency induced by indoleamine 2,3-dioxygenase 1 results in glucose transporter 1-dependent promotion of aerobic glycolysis in pancreatic cancer - PMC
CTSB promotes sepsis-induced acute kidney injury through activating mitochondrial apoptosis pathway - PMC
Journal
Frontiers in immunology
Lnc90386 Sponges miR-33-5p to Mediate Mycoplasma gallisepticum-Induced Inflammation and Apoptosis in Chickens via the JNK Pathway - PMC
Journal
Frontiers in immunology
Engineered bone marrow mesenchymal stem cell-derived exosomes loaded with miR302 through the cardiomyocyte specific peptide can reduce myocardial
Journal
Journal of translational medicine
Characterization of a polysaccharide from Sanghuangporus vaninii and its antitumor regulation via activation of the p53 signaling pathway in breast cancer MCF-7 …
Journal
Int J Biol Macromol
Species
Sanghuangporus vaninii
tRF-33-P4R8YP9LON4VDP inhibits gastric cancer progression via modulating STAT3 signaling pathway in an AGO2-dependent manner
Genetic and pharmacological targeting of XBP1 alleviates hepatic ischemia reperfusion injury by enhancing FoxO1-dependent mitophagy
Journal
Translational research : the journal of laboratory and clinical medicine
DHPA Protects SH-SY5Y Cells from Oxidative Stress-Induced Apoptosis via Mitochondria Apoptosis and the Keap1/Nrf2/HO-1 Signaling Pathway - PMC
Journal
Antioxidants (Basel, Switzerland)
miR-135a Suppresses Granulosa Cell Growth by Targeting Tgfbr1 and Ccnd2 during Folliculogenesis in Mice
LTB4R Promotes the Occurrence and Progression of Clear Cell Renal Cell Carcinoma (ccRCC) by Regulating the AKT/mTOR Signaling Pathway - PMC
Bisdemethoxycurcumin alleviates vandetanib-induced cutaneous toxicity in vivo and in vitro through autophagy activation
Journal
Biomed Pharmacother
Angelica sinensis polysaccharides ameliorated 5-Fluorouracil-induced damage of early B cell progenitors by alleviating oxidative stress of IL-7 producing
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Garcinone E triggers apoptosis and cell cycle arrest in human colorectal cancer cells by mediating a reactive oxygen species–dependent JNK signaling …
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Exercise attenuates angiotensinⅡ-induced muscle atrophy by targeting PPARγ/miR-29b
Journal
J Sport Health Sci
The combined effects of polystyrene of different sizes and cadmium in mouse kidney tissues
Journal
Ecotoxicology and environmental safety
Sophflarine A, a novel matrine-derived alkaloid from Sophora flavescens with therapeutic potential for non-small cell lung cancer through ROS-mediated pyroptosis
Journal
Phytomedicine : international journal of phytotherapy and phytopharmacology
Suppressing SENP1 inhibits esophageal squamous carcinoma cell growth via SIRT6 SUMOylation
Journal
Cellular oncology (Dordrecht)
Icariin ameliorates spermatogenesis disorder in obese mice induced by highfat diet through regulating the glycolytic pathway
Journal
Molecular nutrition & food research
Sodium New Houttuyfonate Induces Apoptosis of Breast Cancer Cells via ROS/PDK1/AKT/GSK3β Axis - PMC
High PPT1 expression predicts poor clinical outcome and PPT1 inhibitor DC661 enhances sorafenib sensitivity in hepatocellular carcinoma
Journal
Cancer cell international
Species
Homo sapiens, Mus musculus
Confusoside, a dihydrochalcone glucoside, prevents acetaminophen-induced liver injury by modulating the Keap1-Nrf2/Nf-κB/Caspase signaling pathway
Latex Derived from Ficus carica L. Inhibited the Growth of NSCLC by Regulating the Caspase/Gasdermin/AKT Signaling Pathway
Paclitaxel Overload Supramolecular Oxidative Stress Nanoamplifier with a CDK12 Inhibitor for Enhanced Cancer Therapy
Changes in the Expression and Functional Activities of C-X-C Motif Chemokine Ligand 13 (CXCL13) in Hyperplastic Prostate - PMC
Journal
International journal of molecular sciences
Species
Homo sapiens, Rattus norvegicus
Molecular Mechanism of the Asarum-Angelica Drug Pair in the Treatment of Periodontitis Based on Network Pharmacology and Experimental Verification - PMC
Journal
International journal of molecular sciences
Mallotucin D, a Clerodane Diterpenoid from Croton crassifolius, Suppresses HepG2 Cell Growth via Inducing Autophagic Cell Death and Pyroptosis - PMC
Journal
International journal of molecular sciences
Crizotinib induces pulmonary toxicity by blocking autophagy flux in alveolar epithelial cells
Journal
Biochemical pharmacology
Galectin-7 promotes cisplatin efficacy by facilitating apoptosis and G3BP1 degradation in cervical cancer
Journal
Biochemical pharmacology
Aucubin protects mouse cochlear hair cells from cisplatin-induced ototoxicity via activation of the PI3K/AKT/STAT3 pathway
Journal
Biochemical pharmacology
Hyperinsulinemia impairs the metabolic switch to ketone body utilization in proximal renal tubular epithelial cells under energy crisis via the inhibition of the SIRT3/SMCT1 pathway - PMC
Journal
Frontiers in endocrinology
Curdione Relieved Isoproterenol-Induced Myocardial Damage through Inhibiting Oxidative Stress and Apoptosis
Journal
The American journal of Chinese medicine
Protective effects of menthol against sepsis-induced hepatic injury: Role of mediators of hepatic inflammation, apoptosis, and regeneration - PMC
Journal
Frontiers in pharmacology
Triptolide inhibits epithelial ovarian tumor growth by blocking the hedgehog/Gli pathway - PMC
Glycyrrhizic Acid against Mycoplasma gallisepticum-Induced Inflammation and Apoptosis Through Suppressing the MAPK Pathway in Chickens
Journal
Journal of agricultural and food chemistry
Myricetin Suppresses Ovarian Cancer In Vitro by Activating the p38/Sapla Signaling Pathway and Suppressing Intracellular Oxidative Stress
Journal
Frontiers in oncology
6-Gingerol protects against cerebral ischemia/reperfusion injury by inhibiting NLRP3 inflammasome and apoptosis via TRPV1/FAF1 complex dissociation-mediated autophagy
Journal
Int Immunopharmacol
Methyl eugenol attenuates liver ischemia reperfusion injury via activating PI3KAkt signaling
Journal
Int Immunopharmacol
Procyanidin B2 ameliorates the progression of osteoarthritis: An in vitro and in vivo study
Journal
International immunopharmacology
Polo-like kinase 1 promotes sepsis-induced myocardial dysfunction
Journal
International immunopharmacology
Caffeic acid modulates activation of neutrophils and attenuates sepsis-induced organ injury by inhibiting 5-LOX/LTB4 pathway
Journal
International immunopharmacology
Avian safety guardian: Luteolin restores Mycoplasma gallisepticum-induced immunocompromise to improve production performance via inhibiting the IL-17/NF-kB
Journal
International immunopharmacology
H3K27ac acts as a molecular switch for doxorubicin-induced activation of cardiotoxic genes - PMC
Journal
Clinical epigenetics
Quercetin Ameliorates Myocardial Injury in Diabetic Rats by Regulating Autophagy and Apoptosis through AMPK/mTOR Signaling Pathway
Journal
The American journal of Chinese medicine
WSB1, as an E3 ligase, restrains myocardial ischemia-reperfusion injury by activating -catenin signaling via promoting GSK3 ubiquitination - PMC
Journal
Molecular medicine (Cambridge, Mass.)
Discovery of a small-molecule NDR1 agonist for prostate cancer therapy - PMC
Journal
Frontiers in pharmacology
Prenatal EGCG exposure-induced heart mass reduction in adult male mice and underlying mechanisms
Safranal alleviates pentetrazole-induced epileptic seizures in mice by inhibiting the NF-B signaling pathway and mitochondrial-dependent apoptosis through GSK-3
Journal
Journal of ethnopharmacology
miR193b3p and miR346 Exert Antihypertensive Effects in the Rostral Ventrolateral Medulla
Journal
Journal of the American Heart Association
Endogenous S100P-mediated autophagy regulates the chemosensitivity of leukemia cells through the p53/AMPK/mTOR pathway
Journal
American journal of cancer research
Thymosin beta 4 alleviates non-alcoholic fatty liver by inhibiting ferroptosis via up-regulation of GPX4 0
Design, synthesis, biological evaluation of novel piperidine-based derivatives as potent poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors
Journal
Bioorganic chemistry
LncRNA FAS-AS1 upregulated by its genetic variation rs6586163 promotes cell apoptosis in nasopharyngeal carcinoma through regulating mitochondria function and Fas splicing - PMC
Journal
Scientific reports
Pan-EGFR Inhibitor Dacomitinib Resensitizes Paclitaxel and Induces Apoptosis via Elevating Intracellular ROS Levels in Ovarian Cancer SKOV3-TR Cells - PMC
Journal
Molecules (Basel, Switzerland)
Deubiquitinating enzyme PSMD7 promotes bladder cancer development: Involvement of RAB1A stabilization
Journal
Cellular signalling
DHCR7 promotes tumorigenesis via activating PI3K/AKT/mTOR signalling pathway in bladder cancer
Journal
Cellular Signalling
RIOK2 Inhibitor NSC139021 Exerts Anti-Tumor Effects on Glioblastoma via Inducing Skp2-Mediated Cell Cycle Arrest and Apoptosis
Tephrosin Suppresses the Chemoresistance of Paclitaxel-Resistant Ovarian Cancer via Inhibition of FGFR1 Signaling Pathway - PMC
Thiram exposure: Disruption of the blood-testis barrier and altered apoptosis-autophagy dynamics in testicular cells via the Bcl-2/Bax and mTOR/Atg5/p62 pathways in
Journal
Pesticide biochemistry and physiology
Chlorpyrifos-mediated mitochondrial calcium overload induces EPC cell apoptosis via ROS/AMPK/ULK1
Journal
Fish & shellfish immunology
Liensinine inhibits progression of intrahepatic cholangiocarcinoma by regulating TGF1/Psmad3 signaling through HIF1a
Journal
Molecular carcinogenesis
Maternal exposure to PM2. 5 decreases ovarian reserve in neonatal offspring mice through activating PI3K/AKT/FoxO3a pathway and ROS-dependent NF-κB pathway
Spleen Toxicity of Organophosphorus Flame Retardant TDCPP in Mice and the Related Mechanisms - PMC
Dimethoxytolyl propylresorcinol induces apoptosis and mitophagy in human leukemia cells through the PI3K/AKT pathway - PMC
Species
Dianella ensifolia,Homo sapiens
Involvement of estrogen receptor activation in kaempferol-3-O-glucoside's protection against aging-related cognition impairment and microglial inflammation
Journal
Experimental cell research
Emodin derivative E35 and its combination with autophagy inhibitor against acute myeloid leukemia cells in vitro and in vivo
Journal
Experimental cell research
Amlexanox Enhances Temozolomide-Induced Antitumor Effects in Human Glioblastoma Cells by Inhibiting IKBKE and the Akt-mTOR Signaling Pathway
Ginsenoside Rd reduces cell proliferation of non-small cell lung cancer cells by p53-mitochondrial apoptotic pathway - PMC
Methyl-CpG-binding domain 3 (Mbd3) is an important regulator for apoptosis in mouse embryonic stem cells
Mycoplasma gallisepticum escapes the host immune response via gga-miR-365-3p/SOCS5/STATs axis - PMC
Journal
Veterinary research
Rosemarinic acid protects -cell from STZ-induced cell damage via modulating NF- pathway - PMC
miR-21-5p prevents doxorubicin-induced cardiomyopathy by downregulating BTG2 - PMC
AP39, a novel mitochondria-targeted hydrogen sulfide donor ameliorates doxorubicin-induced cardiotoxicity by regulating the AMPK/UCP2 pathway
Inhibition of miR-423-5p exerts neuroprotective effects in an experimental rat model of cerebral ischemia/reperfusion injury
Identification of Dalbergiae Odoriferae Lignum active ingredients and potential mechanisms in the treatment of adriamycin-induced cardiotoxicity based on network
Journal
Naunyn-Schmiedeberg's archives of pharmacology
Ojeok-san enhances platinum sensitivity in ovarian cancer by regulating adipocyte paracrine IGF1 secretion
UHMK1 promotes lung adenocarcinoma oncogenesis by regulating the PI3K/AKT/mTOR signaling pathway
Identification of HK3 as a promising immunomodulatory and prognostic target in sepsis-induced acute lung injury
Journal
Biochemical and biophysical research communications
GPX4 inhibits apoptosis of thyroid cancer cells through regulating the FKBP8/Bcl-2 axis - PMC
Journal
Cancer biomarkers : section A of Disease markers
Baicalin attenuates aflatoxin B1-induced hepatotoxicity via suppressing c-Jun-N-terminal kinase-mediated cell apoptosis
Journal
Mycotoxin research
H-151 attenuates lipopolysaccharide-induced acute kidney injury by inhibiting the STING-TBK1 pathway - PMC
Autophagic and apoptotic proteins in goat corpus luteum and the effect of Adiponectin/AdipoRon on luteal cell autophagy and apoptosis
1,4,5,6,7,8-Hexahydropyrido[4,3-d]pyrimidine inhibits HepG2 cell proliferation, migration and invasion, and induces apoptosis through the upregulation of miR-26b-5p by targeting CDK8 - PMC
Inhibition of LAMP3 mediates the protective effect of vitamin D against hypoxia/reoxygenation in trophoblast cells - PMC
Journal
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
Network pharmacology and experimental validation to study the potential mechanism of Tongguanteng injection in regulating apoptosis in osteosarcoma - PMC
Journal
BMC complementary medicine and therapies
Protective effect of ginsenoside Rb1 against aconitine cardiotoxicity studied by myocardial injury, action potential, and calcium signaling
Journal
Toxicon : official journal of the International Society on Toxinology
Protective effects of miR?155?5p silencing on IFN?γ?induced apoptosis and inflammation in salivary gland epithelial cells
Renal Protective Mechanisms of Shenyuan Particle in Db/Db Mice: A Study Based on Network Pharmacology - PMC
Journal
Evidence-based complementary and alternative medicine : eCAM
Asperuloside Promotes Apoptosis of Cervical Cancer Cells through Endoplasmic Reticulum Stress-Mitochondrial Pathway
Journal
Chinese journal of integrative medicine
ATF3 regulates oxidative stress and extracellular matrix degradation via p38/Nrf2 signaling pathway in pelvic organ prolapse
Integrated Analysis Reveals COL4A3 as a Novel Diagnostic and Therapeutic Target in UV-Related Skin Cutaneous Melanoma - PMC
Journal
Clinical, cosmetic and investigational dermatology
NeiyiKangfu tablets control the progression of endometriosis through inhibiting RAF/MEK/ERK signal pathway by targeting RKIP
Journal
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
miR-100-5p is upregulated in multiple myeloma and involves in the pathogenesis of multiple myeloma through targeting MTMR3
Journal
Hematology (Amsterdam, Netherlands)
RING finger protein 5 protects against acute myocardial infarction by inhibiting ASK1 - PMC
Journal
BMC cardiovascular disorders
A recombinant plasmid encoding human hepatocyte growth factor promotes healing of combined radiation-trauma skin injury involved in regulating Nrf2 pathway in
Journal
Journal of radiation research
Knockdown of HDAC9 attenuates sepsis-induced myocardial injury and inflammatory response
Journal
Experimental animals
Total flavonoids of Cynomorium songaricum attenuates cognitive defects in an A1-42-induced Alzheimers disease rat model by activating BDNF/TrkB signaling transduction - PMC
HOXD10 regulates intestinal permeability and inhibits inflammation of dextran sulfate sodium-induced ulcerative colitis through the inactivation of the Rho/ROCK/MMPs axis - PMC
Journal
Open medicine (Warsaw, Poland)
Non-alcoholic fatty liver disease promotes breast cancer progression through upregulated hepatic fibroblast growth factor 21 - PMC
Journal
Cell death & disease
Acetylation stabilizes the signaling protein WISP2 by preventing its degradation to suppress the progression of acute myeloid leukemia
Journal
The Journal of biological chemistry