Recombinant protein (or fragment).This information is considered to be commercially sensitive.
克隆号
ARC5128-01
产品形式
Liquid
偶联物
ABflo® 488. Ex:491nm. Em:516nm.
克隆号
ARC5128-01
产品形式
Liquid
偶联物
ABflo® 488. Ex:491nm. Em:516nm.
细胞定位
actin cytoskeleton, external side of plasma membrane, extracellular exosome, nucleoplasm, plasma membrane.
存储缓冲液
Store at 2-8℃. Avoid freeze. Buffer: PBS containing 0.2% BSA, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
Flow Cytometry analysis of H460 cells and A549 cells, using ABflo® 488 Rabbit anti-Human PD-L1/CD274 monoclonal antibody, the positive signal transition is obvious.
Publishing research using A22304? Please let us know so that we can cite the reference in this datasheet.
背景信息
This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants.
