2-microglobulin functions as an endogenous NMDAR antagonist to impair synaptic function
circEXOC6B interacting with RRAGB, an mTORC1 activator, inhibits the progression of colorectal cancer by antagonizing the HIF1A-RRAGB-mTORC1 positive feedback loop - PMC
circEXOC6B interacting with RRAGB, an mTORC1 activator, inhibits the progression of colorectal cancer by antagonizing the HIF1A-RRAGB-mTORC1 positive feedback loop - PMC
Tripartite motif 16 ameliorates nonalcoholic steatohepatitis by promoting the degradation of phospho-TAK1
UBE2M-mediated neddylation of TRIM21 regulates obesity-induced inflammation and metabolic disorders
Recycling of autophagosomal components from autolysosomes by the recycler complex
Journal
Nature cell biology
Gremlin1 is a therapeutically targetable FGFR1 ligand that regulates lineage plasticity and castration resistance in prostate cancer
Cnot8 eliminates nave regulation networks and is essential for nave-to-formative pluripotency transition
Journal
Nucleic acids research
RNA-binding protein RBM5 plays an essential role in acute myeloid leukemia by activating the oncogenic protein HOXA9 - PMC
Hyodeoxycholic acid ameliorates nonalcoholic fatty liver disease by inhibiting RAN-mediated PPAR nucleus-cytoplasm shuttling - PMC
Journal
Nature communications
ERK and USP5 govern PD-1 homeostasis via deubiquitination to modulate tumor immunotherapy - PMC
Journal
Nature communications
SETDB1 Methylates MCT1 Promoting Tumor Progression by Enhancing the Lactate Shuttle
Journal
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Metabolic crosstalk between skeletal muscle cells and liver through IRF4-FSTL1 in nonalcoholic steatohepatitis - PMC
Journal
Nature communications
Neddylation of Coro1a determines the fate of multivesicular bodies and biogenesis of extracellular vesicles
Journal
J Extracell Vesicles
The Compromised Fanconi Anemia Pathway in Prelamin AExpressing Cells Contributes to Replication StressInduced Genomic Instability
Journal
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
NF-B factors cooperate with Su(Hw)/E4F1 to balance Drosophila/human immune responses via modulating dynamic expression of miR-210
Journal
Nucleic acids research
Species
Drosophila melanogaster
Increased alveolar epithelial TRAF6 via autophagy-dependent TRIM37 degradation mediates particulate matter-induced lung metastasis
Design and synthesis of APN and 3CLpro dualtarget inhibitors based on STSBPT with anticoronavirus activity
Journal
Journal of medical virology
Nuclear AGO2 promotes myocardial remodeling by activating ANKRD1 transcription in failing hearts
Journal
Molecular therapy : the journal of the American Society of Gene Therapy
PABPC1L induces IDO1 to promote tryptophan metabolism and immune suppression in renal cell carcinoma
Species
Homo sapiens,Mus musculus
NR4A3 prevents diabetes induced atrial cardiomyopathy by maintaining mitochondrial energy metabolism and reducing oxidative stress - PMC
Macrophage-derived FGFR1 drives atherosclerosis through PLC-mediated activation of NF-B inflammatory signaling pathway
Journal
Cardiovascular research
Shank3 ameliorates neuronal injury after cerebral ischemia/reperfusion via inhibiting oxidative stress and inflammation
m6A contributes to a pro-survival state in GC-2 cells by facilitating DNA damage repair: Novel perspectives on the mechanism underlying DEHP genotoxicity in male
Journal
The Science of the total environment
Sleep Deprivation Promotes Endothelial Inflammation and Atherogenesis by Reducing Exosomal miR-182-5p
Journal
Arteriosclerosis, thrombosis, and vascular biology
Tetrandrine synergizes with MAPK inhibitors in treating KRAS-mutant pancreatic ductal adenocarcinoma via collaboratively modulating the TRAIL-death
Journal
Pharmacological research
Hippo signaling suppresses tumor cell metastasis via a Yki-Src42A positive feedback loop
Distinct Ring1b complexes defined by DEAD-box helicases and EMT transcription factors synergistically enhance E-cadherin silencing in breast cancer
Structural Basis of VSIG3: The Ligand for VISTA
Single-Cell Transcriptome Analysis of Chronic Antibody-Mediated Rejection After Renal Transplantation
Journal
Frontiers in immunology
YTHDF1 promotes mRNA degradation via YTHDF1AGO2 interaction and phase separation
Journal
Cell proliferation
Prenatal dexamethasone exposure impairs rat blood-testis barrier function and sperm quality in adult offspring via GR/KDM1B/FSTL3/TGF signaling
Journal
Acta pharmacologica Sinica
ULK phosphorylation of STX17 controls autophagosome maturation via FLNA
Journal
Journal of Cell Biology
PI3K/HSCB axis facilitates FOG1 nuclear translocation to promote erythropoiesis and megakaryopoiesis - PMC
Selenoprotein K enhances STING oligomerization to facilitate antiviral response - PMC
20-Hydroxyecdysone counteracts insulin to promote programmed cell death by modifying phosphoglycerate kinase 1 - PMC
Species
Helicoverpa armigera
RPLP2 activates TLR4 in an autocrine manner and promotes HIF-1-induced metabolic reprogramming in hepatocellular carcinoma - PMC
Journal
Cell death discovery
TNC upregulation promotes glioma tumourigenesis through TDG-mediated active DNA demethylation - PMC
Journal
Cell death discovery
Zika virus non-structural protein 4B interacts with DHCR7 to facilitate viral infection
circGRHPR inhibits aberrant epithelial-mesenchymal transformation progression of lung epithelial cells associated with idiopathic pulmonary fibrosis - PMC
Journal
Cell biology and toxicology
Bovine Herpesvirus 1 Productive Infection Led to Inactivation of Nrf2 Signaling through Diverse Approaches
Journal
Oxidative Medicine and Cellular Longevity
An alpha-herpesvirus employs host HEXIM1 to promote viral transcription
Journal
Journal of virology
Hsa_circ_0007590/PTBP1 complex reprograms glucose metabolism by reducing the stability of m6A-modified PTEN mRNA in pancreatic ductal adenocarcinoma
Journal
Cancer gene therapy
Pine nut antioxidant peptides ameliorate the memory impairment in a scopolamine-induced mouse model via SIRT3-induced synaptic plasticity
Effect of CDK7 inhibitor on MYCN-amplified retinoblastoma
Journal
Biochimica et biophysica acta. Gene regulatory mechanisms
tRNA-derived small RNA (tsr007330) regulates myocardial fibrosis after myocardial infarction through NAT10-mediated ac4C acetylation of EGR3 mRNA
Journal
Biochimica et biophysica acta. Molecular basis of disease
E3 Ubiquitin Ligase FBXO3 Drives Neuroinflammation to Aggravate Cerebral Ischemia/Reperfusion Injury - PMC
Journal
International journal of molecular sciences
HERV-W ENV Induces Innate Immune Activation and Neuronal Apoptosis via linc01930/cGAS Axis in Recent-Onset Schizophrenia - PMC
Journal
International journal of molecular sciences
Anti-Coronavirus Potential of Polyether Ionophores: The New Application of Veterinary Antibiotics in Livestock
Journal
Journal of agricultural and food chemistry
DAB2IP suppresses invadopodia formation through destabilizing ALK by interacting with USP10 in breast cancer - PMC
The Metabolites of Lactobacillus fermentum F-B9-1 Relieved Dextran Sulfate Sodium-Induced Experimental Ulcerative Colitis in Mice
Journal
Frontiers in microbiology
GALNT2 sustains glioma stem cells by promoting CD44 expression - PMC
DDX19A promotes gastric cancer cell proliferation and migration by activating the PI3K/AKT pathway - PMC
Journal
Cancer cell international
FBXW5 acts as a negative regulator of pathological cardiac hypertrophy by decreasing the TAK1 signaling to pro-hypertrophic members of the MAPK signaling pathway
Journal
J Mol Cell Cardiol
Large Multicohort Study Reveals a Prostate Cancer Susceptibility Allele at 5p15 Regulating TERT via Androgen Signaling-Orchestrated Chromatin Binding of E2F1 and MYC
Engineering singledomain antibodies targeting Gasdermin E activation by the chemotherapeutic agent cisdiaminodichloroplatinum
Journal
Biotechnology journal
MUC1 induces the accumulation of Foxp3+ Treg cells in the tumor microenvironment to promote the growth and metastasis of cholangiocarcinoma through the EGFR …
Journal
International immunopharmacology
PINK1/Parkin-mediated mitophagy mitigates T-2 toxin-induced nephrotoxicity
Journal
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Nuclear autoantigenic sperm protein facilitates glioblastoma progression and radioresistance by regulating the ANXA2/STAT3 axis - PMC
Journal
CNS neuroscience & therapeutics
Fibulin-3 regulates the inhibitory effect of TNF- on chondrocyte differentiation partially via the TGF-/Smad3 signaling pathway
Journal
Biochimica et biophysica acta. Molecular cell research
mRNA m5C controls adipogenesis by promoting CDKN1A mRNA export and translation
Development and characterization of a novel bipedal standing mouse model of intervertebral disc and facet joint degeneration
Journal
Clinical orthopaedics and related research
Japanese Flounder HMGB1: A DAMP Molecule That Promotes Antimicrobial Immunity by Interacting with Immune Cells and Bacterial Pathogen - PMC
The identification of alternative oxidase in intermediate host snails of Schistosoma and its potential role in protecting Oncomelania hupensis against niclosamide-induced stress
Journal
Parasites & vectors
Species
Oncomelania hupensis
Circular RNA circLIFR suppresses papillary thyroid cancer progression by modulating the miR-429/TIMP2 axis - PMC
Journal
Journal of cancer research and clinical oncology
Relish-facilitated lncRNA-CR11538 suppresses Drosophila Imd immune response and maintains immune homeostasis via decoying Relish away from antimicrobial
Journal
Developmental and comparative immunology
Species
Drosophila melanogaster
Dexmedetomidine Mitigates Microglial Activation Associated with Postoperative Cognitive Dysfunction by Modulating the MicroRNA-103a-3p/VAMP1 Axis
Qing Zao Fang (QZF) Alleviates the Inflammatory Microenvironment of the Submandibular Gland in Sjögren's Syndrome Based on the PI3K/Akt/HIF-1 α /VEGF Signaling Pathway
circ_0001461 promotes oral squamous cell carcinoma progression through miR-145/TLR4/NF-κB axis
Journal
Biochem Biophys Res Commun
SH3BGRL3, transcribed by STAT3, facilitates glioblastoma tumorigenesis by activating STAT3 signaling
Journal
Biochem Biophys Res Commun
β-cantenin is potentially involved in the regulation of c-Jun signaling following bovine herpesvirus 1 infection
LncRNA LINC00281/Annexin A2 Regulates Vascular Smooth Muscle Cell Phenotype Switching via the Nuclear Factor-Kappa B Signaling Pathway
Journal
Journal of cardiovascular translational research
Functional ectopic neural lobe increases GAP-43 expression via PI3K/AKT pathways to alleviate central diabetes insipidus after pituitary stalk lesion in rats
Journal
Neuroscience letters
Chitotriosidase enhances TGFβ-Smad signaling and uptake of β-amyloid in N9 microglia
Journal
Neuroscience letters
Extract of the aerial part of polygala tenuifolia attenuates d-Galactose/NaNO2-induced learning and memory impairment in mice
Integrated Network Pharmacology and Mice Model to Investigate Qing Zao Fang for Treating Sjögren's Syndrome
Journal
Evidence-based complementary and alternative medicine : eCAM
ANXA9 facilitates S100A4 and promotes breast cancer progression through modulating STAT3 pathway - PMC
Journal
Cell death & disease
4-octyl itaconate as a metabolite derivative inhibits inflammation via alkylation of STING
Protein phosphatase 1 regulatory subunit 15A promotes translation initiation and induces G2M phase arrest during cuproptosis in cancers - PMC
Journal
Cell death & disease
KAT8 is upregulated and recruited to the promoter of Atg8 by FOXO to induce H4 acetylation for autophagy under 20-hydroxyecdysone regulation
Journal
The Journal of biological chemistry
Type I interferon/STAT1 signaling regulates UBE2M-mediated antiviral innate immunity in a negative feedback manner
Species
Homo sapiens, Mus musculus
Krppel-like factor 5 rewires NANOG regulatory network to activate human naive pluripotency specific LTR7Ys and promote naive pluripotency
Lysine crotonylation regulates leucine-deprivation-induced autophagy by a 14-3-3ε-PPM1B axis