Age-associated telomere attrition in adipocyte progenitors predisposes to metabolic disease
The proteasome component PSMD14 drives myelomagenesis through a histone deubiquitinase activity
Disparate macrophage responses are linked to infection outcome of Hantan virus in humans or rodents - PMC
Journal
Nature communications
Species
Homo sapiens,Mus musculus
CircTmeff1 Promotes Muscle Atrophy by Interacting with TDP‐43 and Encoding A Novel TMEFF1‐339aa Protein
Journal
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Blue light promotes vitamin C-mediated ferroptosis of melanoma through specifically upregulating transporter SVCT2 and generating Fe2+
Porcine reproductive and respiratory syndrome virus degrades DDX10 via SQSTM1/p62-dependent selective autophagy to antagonize its antiviral activity
ZNFX1 promotes AMPK-mediated autophagy against Mycobacterium tuberculosis by stabilizing mRNA
Carbon dioxide inhibits COVID-19-type proinflammatory responses through extracellular signal-regulated kinases 1 and 2, novel carbon dioxide sensors
The Role of Vasoactive Intestinal Peptide and Mast Cells in the Regulatory Effect of Lactobacillus casei ATCC 393 on Intestinal Mucosal Immune Barrier
Amelioration of Lupus Serum-Induced Skin Inflammation in CD64-Deficient Mice
Journal
Frontiers in immunology
Controlled release of dopamine coatings on titanium bidirectionally regulate osteoclastic and osteogenic response behaviors
Journal
Materials science & engineering. C, Materials for biological applications
BMSC-derived exosomes promote tendon-bone healing after anterior cruciate ligament reconstruction by regulating M1/M2 macrophage polarization in rats - PMC
Journal
Stem cell research & therapy
Biochanin A Ameliorates Nephropathy in High-Fat Diet/Streptozotocin-Induced Diabetic Rats: Effects on NF-kB/NLRP3 Axis, Pyroptosis, and Fibrosis - PMC
Journal
Antioxidants (Basel, Switzerland)
BAFF Blockade Attenuates Inflammatory Responses and Intestinal Barrier Dysfunction in a Murine Endotoxemia Model
Journal
Frontiers in Immunology
Discovery of a novel cyclin-dependent kinase 8 inhibitor with an oxindole core for anti-inflammatory treatment
Journal
Biomed Pharmacother
Species
Homo sapiens, Mus musculus
Ginsenoside Rg1 ameliorates hypoxia-induced pulmonary arterial hypertension by inhibiting endothelial-to-mesenchymal transition and inflammation by
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Ginsenoside Rg1 ameliorates hypoxia-induced pulmonary arterial hypertension by inhibiting endothelial-to-mesenchymal transition and inflammation by
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Trichodermin inhibits the growth of oral cancer through apoptosis-induced mitochondrial dysfunction and HDAC-2-mediated signaling
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Aldehyde Dehydrogenase 2 Protects the Kidney from Ischemia-Reperfusion Injury by Suppressing the IκBα/NF-κB/IL-17C Pathway - PMC
Journal
Oxidative medicine and cellular longevity
Inhibition of Brd4 alleviates osteoarthritis pain via suppression of neuroinflammation and activation of Nrf2mediated antioxidant signaling
Journal
British Journal of Pharmacology
SIRT1/FOXO3-mediated autophagy signaling involved in manganese-induced neuroinflammation in microglia
Journal
Ecotoxicology and environmental safety
Resveratrol attenuated oxidative stress and inflammatory and mitochondrial dysfunction induced by acute ammonia exposure in gibel carp (Carassius gibelio)
Journal
Ecotoxicology and environmental safety
Design, synthesis, and biological evaluation of a novel dual peroxisome proliferator-activated receptor alpha/delta agonist for the treatment of diabetic kidney disease through anti-inflammatory mechanisms
PIGU promotes hepatocellular carcinoma progression through activating NF-κB pathway and increasing immune escape
Protective effects of E Se tea extracts against alcoholic fatty liver disease induced by high fat/alcohol diet: In vivo biological evaluation and molecular docking study
Journal
Phytomedicine : international journal of phytotherapy and phytopharmacology
ISM1 suppresses LPS-induced acute lung injury and post-injury lung fibrosis in mice - PMC
Journal
Molecular medicine (Cambridge, Mass.)
Preparation, characterization, and in vivo evaluation of anti-inflammatory activities of selenium nanoparticles synthesized by Kluyveromyces lactis GG799
Investigation of the active components and mechanisms of Schisandra chinensis in the treatment of asthma based on a network pharmacology approach and experimental validation
Species
Rattus norvegicus,Schisandra chinensis
Confusoside, a dihydrochalcone glucoside, prevents acetaminophen-induced liver injury by modulating the Keap1-Nrf2/Nf-κB/Caspase signaling pathway
The mechanism of ginger and its processed products in the treatment of estradiol valerate coupled with oxytocin-induced dysmenorrhea in mice via regulating …
The preventive effect and underlying mechanism of Rhus chinensis Mill. fruits on dextran sulphate sodium-induced ulcerative colitis in mice
Porcine Circovirus Type 2 Infection Activates NF-κB pathway and Cellular Inflammatory Responses through circPDCD4/miR-21/PDCD4 Axis in Porcine Kidney 15 Cell
ADAR1 suppression causes interferon signaling and transposable element transcript accumulation in human astrocytes - PMC
Journal
Frontiers in molecular neuroscience
The Extracts of Dendrobium Alleviate Dry Eye Disease in Rat Model by Regulating Aquaporin Expression and MAPKs/NF-κB Signalling - PMC
Journal
International journal of molecular sciences
Repetitive Transcranial Magnetic Stimulation Improves Neurological Function and Promotes the Anti-inflammatory Polarization of Microglia in Ischemic Rats
Journal
Frontiers in cellular neuroscience
Zeb1 regulation of wound-healing-induced inflammation in alkali-damaged corneas
Whitening of brown adipose tissue inhibits osteogenic differentiation via secretion of S100A8/A9 - PMC
Whitening of brown adipose tissue inhibits osteogenic differentiation via secretion of S100A8/A9 - PMC
SHIP1 Activator AQX-1125 Regulates Osteogenesis and Osteoclastogenesis Through PI3K/Akt and NF-κb Signaling
Journal
Frontiers in cell and developmental biology
Resatorvid protects against hypoxic-ischemic brain damage in neonatal rats.
Journal
Neural Regeneration Research
Sophoridine inhibits endotoxin-induced acute lung injury by enhancing autophagy of macrophage and reducing inflammation
Journal
Journal of leukocyte biology
Hyperoside Protects Human Umbilical Vein Endothelial Cells Against Anticardiolipin Antibody-Induced Injury by Activating Autophagy
α-Mangostin Alleviated Inflammation in Rats With Adjuvant-Induced Arthritis by Disrupting Adipocytes-Mediated Metabolism-Immune Feedback
Journal
Frontiers in pharmacology
Tumor-derived Immunoglobulin-like transcript 4 facilitates angiogenesis of colorectal cancer
Journal
American journal of cancer research
Rosmarinic Acid Inhibits Platelet Aggregation and Neointimal Hyperplasia In Vivo and Vascular Smooth Muscle Cell Dedifferentiation, Proliferation, and Migration In
Journal
Journal of agricultural and food chemistry
New Insights into Baicalein's Effect on Chlorpyrifos-Induced Liver Injury in Carp: Involving Macrophage Polarization and Pyropto sis
Journal
Journal of agricultural and food chemistry
Dietary Isoquercetin Ameliorates Bone Loss via Restoration of the Gut Microbiota and Lipopolysaccharide-Triggered Inflammatory Status in Ovariectomy Mice
Journal
Journal of agricultural and food chemistry
Fraxin ameliorates lipopolysaccharide-induced acute lung injury in mice by inhibiting the NF-B and NLRP3 signalling pathways.
Journal
International immunopharmacology
Anti-inflammatory effect of Yam Glycoprotein on lipopolysaccharide-induced acute lung injury via the NLRP3 and NF-κB/TLR4 signaling pathway
Journal
International Immunopharmacology
Early depletion of M1 macrophages retards the progression of glucocorticoid-associated osteonecrosis of the femoral head
Journal
International immunopharmacology
Avian safety guardian: Luteolin restores Mycoplasma gallisepticum-induced immunocompromise to improve production performance via inhibiting the IL-17/NF-kB
Journal
International immunopharmacology
Inhibition of NEMO alleviates arthritis by blocking the M1 macrophage polarization
Journal
International immunopharmacology
Enriched Environment Attenuates Pyroptosis to Improve Functional Recovery After Cerebral Ischemia/Reperfusion Injury
Journal
Front Aging Neurosci
Triclocarban exposure aggravates dextran sulfate sodium-induced colitis by deteriorating the gut barrier function and microbial community in mice
Journal
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Copper induces microglia-mediated neuroinflammation through ROS/NF-κB pathway and mitophagy disorder
Journal
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Theabrownin Isolated from Pu-Erh Tea Enhances the Innate Immune and Anti-Inflammatory Effects of RAW264.7 Macrophages via the TLR2/4-Mediated Signaling Pathway - PMC
Journal
Foods (Basel, Switzerland)
BAY61?3606 attenuates neuroinflammation and neurofunctional damage by inhibiting microglial Mincle/Syk signaling response after traumatic brain injury
Biomimetic synthesis and anti-inflammatory evaluation of violacin A analogues
Journal
Bioorganic chemistry
Inula japonica ameliorated bleomycin-induced pulmonary fibrosis via inhibiting soluble epoxide hydrolase
Journal
Bioorganic chemistry
Study on the effect of active components of Schisandra chinensis on liver injury and its mechanisms in mice based on network pharmacology
Anneslea fragrans Wall. ameliorates ulcerative colitis via inhibiting NF-κB and MAPK activation and mediating intestinal barrier integrity
Harmine mitigates LPS-induced acute kidney injury through inhibition of the TLR4-NF-κB/NLRP3 inflammasome signalling pathway in mice.
Journal
European journal of pharmacology
Wutou decoction attenuates the synovial inflammation of collagen-induced arthritis rats via regulating macrophage M1/M2 type polarization
Journal
Journal of ethnopharmacology
TJ-M2010-5, A self-developed MyD88 inhibitor, attenuates liver fibrosis by inhibiting the NF-κB pathway
Journal
Chemico-biological interactions
Oxidative stress and ferroptosis involved in 2-ethylhexyl diphenyl phosphate-induced hepatotoxicity in chicken
Journal
Chemico-biological interactions
Hyperoside attenuates pregnancy loss through activating autophagy and suppressing inflammation in a rat model
Confusoside from Anneslea fragrans Alleviates Acetaminophen-Induced Liver Injury in HepG2 via PI3K-CASP3 Signaling Pathway - PMC
Journal
Molecules (Basel, Switzerland)
LncRNA H19 Mitigates Oxidized Low-Density Lipoprotein Induced Pyroptosis via Caspase-1 in Raw 264.7 Cells
Securidaca inappendiculata-Derived Xanthones Protected Joints from Degradation in Male Rats with Collagen-Induced Arthritis by Regulating PPAR- Signaling
C/EBP Promotes LPS-Induced IL-1 Transcription and Secretion in Alveolar Macrophages via NOD2 Signaling - PMC
Journal
Journal of inflammation research
Protective Effect of Anwulignan on Gastric Injury Induced by Indomethacin in Mice
Journal
The Journal of pharmacology and experimental therapeutics
Ultrasound-Guided Transplantation of Mesenchymal Stem Cells Improves Adriamycin Nephropathy in Rats through the RIPK3/MLKL and TLR-4/NF-κB signaling
Porcine deltacoronavirus nsp15 antagonizes interferon-β production independently of its endoribonuclease activity.
Journal
Molecular Immunology
CBLB502, a toll-like receptor 5 agonist, offers protection against Radiation-Induced male reproductive system damage in mice
Journal
Biology of reproduction
Effects of manganese on microglia M1/M2 polarization and SIRT1-mediated transcription of STAT3-dependent genes in mouse
Berberine inhibits IL-21/IL-21R mediated inflammatory proliferation of fibroblast-like synoviocytes through the attenuation of PI3K/Akt signaling pathway and
Hepatoprotective effects of Camellia nitidissima aqueous ethanol extract against CCl4-induced acute liver injury in SD rats related to Nrf2 and NF-κB signalling
Journal
Pharmaceutical Biology
Rosuvastatin suppresses TNF--induced matrix catabolism, pyroptosis and senescence via the HMGB1/NF-B signaling pathway in nucleus pulposus cells - PMC
Journal
Acta biochimica et biophysica Sinica
Porcine deltacoronavirus nsp10 antagonizes interferon-β production independently of its zinc finger domains
Identification of SLC2A3 as a prognostic indicator correlated with the NF-κB/EMT axis and immune response in head and neck squamous cell carcinoma - PMC
Journal
Channels (Austin, Tex.)
Lactobacillus rhamnosus GG Ameliorates Liver Injury and Hypoxic Hepatitis in Rat Model of CLP-Induced Sepsis.
Journal
Digestive diseases and sciences
Synthesis of nature product kinsenoside analogues with anti-inflammatory activity
Journal
Bioorganic & medicinal chemistry
TAK‑242 exerts a neuroprotective effect via suppression of the TLR4/MyD88/TRIF/NF‑κB signaling pathway in a neonatal hypoxic‑ischemic encephalopathy rat model
TAK‑242 exerts a neuroprotective effect via suppression of the TLR4/MyD88/TRIF/NF‑κB signaling pathway in a neonatal hypoxic‑ischemic encephalopathy rat model
7‑Difluoromethyl‑5,4'‑dimethoxygenistein exerts anti‑angiogenic effects on acute promyelocytic leukemia HL‑60 cells by inhibiting the TLR4/NF‑κB signaling pathway
Journal
Molecular Medicine Reports
Rosiglitazone ameliorates bile duct ligation-induced liver fibrosis by down-regulating NF-κB-TNF-α signaling pathway in a PPARγ-dependent manner.
Journal
Biochemical and Biophysical Research Communications
Mechanistic insights into the amelioration effects of lipopolysaccharide-induced acute lung injury by baicalein: An integrated systems pharmacology study and experimental validation
Journal
Pulmonary pharmacology & therapeutics
Celastrol Attenuates Learning and Memory Deficits in an Alzheimer's Disease Rat Model
LncRNA LINC00281/Annexin A2 Regulates Vascular Smooth Muscle Cell Phenotype Switching via the Nuclear Factor-Kappa B Signaling Pathway
Journal
Journal of cardiovascular translational research
Induction of apoptosis in glioma cells by lycorine via reactive oxygen species generation and regulation of NF-κB pathways
Journal
Naunyn-Schmiedeberg's archives of pharmacology
Moderate mechanical stimulation antagonizes inflammation of annulus fibrosus cells through YAP‐mediated suppression of NF‐κB signaling
Journal
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Fraxin inhibits lipopolysaccharide-induced inflammatory cytokines and protects against endotoxic shock in mice.
Journal
Fundamental & clinical pharmacology
Japanese encephalitis virus induces apoptosis by activating the RIG-1 signaling pathway
Journal
Archives of virology
Jianpi Qingchang Decoction Ameliorates Chronic Colitis in Piroxicam-Induced IL-10 Knockout Mice by Inhibiting Endoplasmic Reticulum Stress
Journal
Evidence-based complementary and alternative medicine : eCAM
Protective Effects of Anwulignan against HCl/Ethanol-Induced Acute Gastric Ulcer in Mice
Journal
Evid Based Complement Alternat Med
Inhibition of TMUB1 blocks apoptosis and NF-κB pathway-mediated inflammation in recurrent spontaneous abortion - PMC
Journal
Immunity, inflammation and disease
Rosuvastatin corrects oxidative stress and inflammation induced by LPS to attenuate cardiac injury by inhibiting the NLRP3/TLR4 pathway
Journal
Canadian journal of physiology and pharmacology
Knockdown of HDAC9 attenuates sepsis-induced myocardial injury and inflammatory response
Journal
Experimental animals