hsa_circ_0007919 induces LIG1 transcription by binding to FOXA1/TET1 to enhance the DNA damage response and promote gemcitabine resistance in pancreatic ductal adenocarcinoma - PMC
Hyperpolyploidization of hepatocyte initiates preneoplastic lesion formation in the liver
Comprehensive multi-omics analysis reveals WEE1 as a synergistic lethal target with hyperthermia through CDK1 super-activation - PMC
Journal
Nature communications
Species
Homo sapiens,Mus musculus
Proteomic characterization of the colorectal cancer response to chemoradiation and targeted therapies reveals potential therapeutic strategies - PMC
Journal
Cell reports. Medicine
Aging hallmarks of the primate ovary revealed by spatiotemporal transcriptomics
Species
Macaca fascicularis
Conserved intronic secondary structures with concealed branch sites regulate alternative splicing of poison exons
Journal
Nucleic acids research
Species
Drosophila melanogaster
Oxygen-Enriched MOF-Hemoglobin Xray Nanosensitizer for Enhanced Cancer RadioRadiodynamic Therapy
Journal
ACS Materials Letters
Codelivery of adavosertib and olaparib by tumor-targeting nanoparticles for augmented efficacy and reduced toxicity
Journal
Acta biomaterialia
RPRD1A stabilizes NRF2 and aggravates HCC progression through competing with p62 for TRIM21 binding
A 1, 2, 3-Triazole Derivative of Quinazoline Exhibits Antitumor Activity by Tethering RNF168 to SQSTM1/P62
Journal
Journal of medicinal chemistry
-Catenin requirement in keratinocyte proliferation and DNA repair identifies a therapeutic target for photoaging
Journal
The Journal of investigative dermatology
-Catenin requirement in keratinocyte proliferation and DNA repair identifies a therapeutic target for photoaging
Journal
The Journal of investigative dermatology
-Catenin requirement in keratinocyte proliferation and DNA repair identifies a therapeutic target for photoaging
Journal
The Journal of investigative dermatology
Novel dual-targeting c-Myc inhibitor D347-2761 represses myeloma growth via blocking c-Myc/Max heterodimerization and disturbing its stability
Journal
Cell communication and signaling : CCS
Quercetin inhibits DNA damage responses to induce apoptosis via SIRT5/PI3K/AKT pathway in non-small cell lung cancer
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Hexavalent chromium triggers hepatocytes premature senescence via the GATA4/NF-B signaling pathway mediated by the DNA damage response
Journal
Ecotoxicology and environmental safety
Species
Homo sapiens, Mus musculus
Cresyl Diphenyl Phosphate exposure induces reproductive functional defects in men and male mice
Journal
Ecotoxicology and environmental safety
N-acetylcysteine alleviated tris (2-chloroisopropyl) phosphate-induced sperm motility decline and functional dysfunction in mice through reversing oxidative
Journal
Ecotoxicology and environmental safety
Ammonium tetrathiomolybdate relieves oxidative stress in cisplatin-induced acute kidney injury via NRF2 signaling pathway
Journal
Cell Death Discovery
Species
Homo sapiens, Mus musculus
Fbxo22 inhibits metastasis in triple-negative breast cancer through ubiquitin modification of KDM5A and regulation of H3K4me3 demethylation
Journal
Cell biology and toxicology
HSP90 promotes radioresistance of cervical cancer cells via reducing FBXO6-mediated CD147 polyubiquitination
Ipatasertib exhibits antitumorigenic effects and enhances sensitivity to paclitaxel in endometrial cancer invitro and invivo
Journal
International journal of oncology
Triphenyl phosphate induces clastogenic effects potently in mammalian cells, human CYP1A2 and 2E1 being major activating enzymes
Journal
Chemico-biological interactions
Pulmonary hypertension without heart failure causes cardiorenal syndrome in a porcine model
Journal
Scientific reports
Toxoflavin analog D43 exerts antiproliferative effects on breast cancer by inducing ROS-mediated apoptosis and DNA damage - PMC
Journal
Scientific reports
N6-methyladenosine regulates ATM expression and downstream signaling
OONO-/MMP2/MMP9 pathway-mediated apoptosis of porcine granulosa cells is associated with DNA damage
Journal
Reproduction (Cambridge, England)
A loss-of-function variant in ZCWPW1 causes human male infertility with sperm head defect and high DNA fragmentation - PMC
Journal
Reproductive health
Atp11b Deletion Affects the Gut Microbiota and Accelerates Brain Aging in Mice
IQGAP3 in clear cell renal cell carcinoma contributes to drug resistance and genome stability - PMC
Peroxiredoxin IV plays a critical role in cancer cell growth and radioresistance through the activation of the Akt/GSK3 signaling pathways - PMC
Journal
The Journal of biological chemistry