产品中心 / 产品类型 / 细胞系&裂解液 / KO细胞裂解液
Genome sequence analysis of PCR products from parental (WT) and PARK2 knockout (KO) HCT116 cells, using sanger sequencing.
The precise function of this gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support. [provided by RefSeq, Jul 2008]
