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This standard curve is only for demonstration purposes. A standard curve should be generated for eachassay.
From the comparison of the standard curve, it is found that ABclonal has highsensitivity.
Placed at 37°C for 3 days, the stability of the standard curve all conformto CV <10%.
* This package insert must be read in its entirety before using this product.
Human IL-33 Sanwich ELISA Immunoassay
| Recommended Concentration | Sample | |
|---|---|---|
| ELISA Capture | 0.5-2ug/mL | Rabbit anti-Human IL-33(CAP)(Cat. No.RM17857) |
| ELISA Detection | 0.033-0.13ug/mL | Rabbit anti-Human IL-33(DET)(Cat. No.RM17858) |
| Standard | 3.125-200pg/mL | Recombinant Human IL-33 Protein |
Interleukin-33 (IL-33), also known as NF-HEV and DVS 27, is a 30 kDa pro-inflammatory protein that plays an important role in Th2-biased immune responses and cardiac pathology . Human IL-33 is synthesized as a 270 amino acid (aa) molecule with an N-terminal nuclear localization signal, a helix-turn-helix motif, and a C-terminal region with structural homology to IL-1 family cytokines . Full length IL-33 interacts with nuclear chromatin, binds NFκB, and inhibits pro-inflammatory NFκB transactivation. Cleavage of full length IL-33 leads to the extracellular release of an 18-20 kDa C-terminal fragment known as mature IL-33. Mature human IL-33 shares 57% and 59% aa sequence identity with mouse and rat IL-33, respectively.
