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This standard curve is only for demonstration purposes. A standard curve should be generated for eachassay.
* This package insert must be read in its entirety before using this product.
Human AGER Sandwich ELISA Immunoassay
| Recommended Concentration | Sample | |
|---|---|---|
| ELISA Capture | 1-4ug/mL | Rabbit anti-Human AGER mAb(CAP)(Cat. No.RM98012) |
| ELISA Detection | 0.06-0.25ug/mL | Rabbit anti-Human AGER mAb(DET)(Cat. No.RM98013) |
| Standard | 31.25-2000pg/mL | Recombinant Human AGER Protein(Cat. No.RP00154) |
Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymaticallyglycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Actsas a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and inparticular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating theproduction/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interactionwith S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, withgeneration of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a rolein myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid betapeptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from theextracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especiallystimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport systemdelivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides
