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Human IL-18 Sandwich Immunoassay
Recommended Concentration | Sample | ||
---|---|---|---|
ELISA/Multiplex | Capture | 1-4ug/mL | Rabbit anti-Human IL-18 mAb(Cat. No.RMK0031) |
Detection | 0.08-0.33ug/mL | Rabbit anti-Human IL-18 mAb(Cat. No.RMK0032) | |
Standard | 15.6-1000pg/mL | Recombinant Human IL-18 Protein |
The protein encoded by this gene is a proinflammatory cytokine of the IL-1 family that is constitutively found as a precursor within the cytoplasm of a variety of cells including macrophages and keratinocytes. The inactive IL-18 precursor is processed to its active form by caspase-1, and is capable of stimulating interferon gamma production, and of regulating both T helper (Th) 1 and Th2 responses. This cytokine has been implicated in the injury of different organs, and in potentially fatal conditions characterized by a cytokine storm. In humans, IL-18 gene is located on chromosome 11. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.