Recombinant Human TNFRSF9/4-1BB/CD137 Protein was determined by SDS-PAGE with Coomassie Blue, showing a band at 25-35 kDa.
Immobilized Human TNFRSF9 (Catalog: RP01698) at 2 μg/mL (100 μL/well) can bind Human TNFSF9 (Catalog: RP00060) with a linear range of 1-4.4 ng/mL.
CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necrosis factor (TNF) receptor superfamily. It is expressed mainly on activated CD4+ and CD8+ T cells, and binds to a high-affinity ligand (4-1BBL) expressed on several antigen-presenting cells such as macrophages and activated B cells. Upon ligand binding, 4-1BB is associated with the tumor necrosis factor receptor–associated factors (TRAFs), the adaptor protein which mediates downstream signaling events including the activation of NF-kappaB and cytokine production. 4-1BB signaling either by binding to 4-1BBL or by antibody ligation delivers signals for T-cell activation and growth, as well as monocyte proliferation and B-cell survival, and plays an important role in the amplification of T cell-mediated immune responses.
