Recombinant Human Claudin-4 Protein (RP02997LQ)

The purity of Human Claudin-4 VLP is greater than 95% as determined by SEC-HPLC.

Immobilized Human Claudin-4 VLP at 1μg/ml (100μl/well) on the plate. Dose response curve for Anti-Claudin 4 Antibody, hFc Tag with the EC₅₀ of 18.4ng/ml determined by ELISA.

All(2)|

货号: RP02997LQ

详细信息

种属

Human

表达宿主

HEK293 cells

Calculated MW

23.31 kDa

标签

No tag

纯度

> 95% as determined by HPLC

内毒素

Less than 1EU per μg by the LAL method.

制剂

Supplied as 0.22μm filtered solution in PBS (pH 7.4). Notice: If you need it for immunization, Do Not use any adjuvant.

描述

Recombinant Human Claudin-4 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Met1-Val209) of human Claudin-4 (Accession #NP_001296.1 ) fused with no additional amino acid.

储存

Store at -70℃. This product is stable at ≤ -70℃ for up to 1 year from the date of receipt. For optimal storage, aliquot into smaller quantities after centrifugation and store at recommended temperature. Avoid repeated freeze-thaw cycles.未开盖的干粉蛋白在 -20°C至-80°C可保存12个月；
复溶之后，蛋白溶液在-20°C及以下可保存3个月，在2-8℃可保存1周。

生物活性

Immobilized Human Claudin-4 VLP at 1μg/ml (100μl/well) on the plate. Dose response curve for Anti-Claudin 4 Antibody, hFc Tag with the EC₅₀ of 18.4ng/ml determined by ELISA.

蛋白复溶计算器

请在蛋白复溶计算器中输入蛋白总质量和所需终浓度，快速计算您需要添加溶液的体积吧！

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折叠内容

背景信息

Claudin-4 (CLDN4) is a key component of tight junctions (TJs) in epithelial cells. CLDN4 is overexpressed in many epithelial malignancies and correlates with cancer progression. Changes in CLDN4 expression have been associated with epigenetic factors (such as hypomethylation of promoter DNA), inflammation associated with infection and cytokines, and growth factor signaling. CLDN4 helps to maintain the tumor microenvironment by forming TJs and acts as a barrier to the entry of anticancer drugs into tumors.

基因ID

1364

Swiss Prot

O14493

别名

Claudin-4; CLDN4; Claudin4; CPE-R; CPE R; CPETR1; WBSCR8

研究领域