APC Mouse anti-Human CD192/CCR2 mAb (A28626)

CCR2 is a chemokine receptor that binds monocyte chemoattractant proteins (MCP-1, -2, -3, and -4). Two alternatively spliced variants (CCR2A and CCR2B) were initially described, which differ in their C-terminal cytoplasmic tails. The adhesion of monocytes to arterial endothelium and their subsequent migration into the intima are central events in the pathogenesis of atherosclerosis. Both CCR2 and MCP-1 are implicated in atherosclerotic plaque formation. MCP-1, induced in endothelial cells by modified low-density lipoprotein (LDL), may trigger firm monocyte attachment to the vascular endothelium under flow conditions. Local overexpression of MCP-1 within the vessel wall induces macrophage infiltration and the development of atherosclerotic lesions. Obesity induces a state of chronic inflammation, which is associated with numerous clinically significant complications, including insulin resistance, diabetes mellitus, atherosclerosis, and non-alcoholic fatty liver disease. CCR2 plays a critical role in the development of obesity and the associated inflammation within adipose tissue.