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外泌体调节许多细胞生物学过程,并与肿瘤、神经系统疾病、心血管疾病等多种疾病的发病机制相关。健康受试者和不同疾病的患者释放到循环系统的外泌体所包含的某些RNA和蛋白质成分具有明显差异,成为潜在的非侵入性生物标志物,可用于多种疾病的检测、预后和治疗,具有重要的转化医学应用价值。

肿瘤外泌体生物标志物

外泌体在肿瘤发生、发展的几个关键阶段起着重要作用,外泌体通过转移致癌蛋白和核酸参与了肿瘤的起始、生长、进程、转移和耐药性[1]。体液中外泌体生物标志物提供了很多重要的肿瘤相关信息,越来越多的证据表明,不同肿瘤外泌体生物标志物可用于肿瘤监测、治疗方式选择和预后评估[2-4]。

肿瘤外泌体生物标志物相关抗体
分类 靶点 产品货号 产品名称 产品应用 反应种属
泛癌种相关外泌体通用标志物 THBS2 A8561 THBS2 Rabbit pAb WB Mouse, Rat
VCAN A19655 Versican Rabbit mAb WB,IHC,IF Human,Mouse,Rat
DNAJA1 A11602 [KO Validated] DNAJA1 Rabbit pAb WB, IF Human, Mouse, Rat
A19865 [KO Validated] DNAJA1 Rabbit pAb WB, IF Human, Mouse, Rat
CRMP2 A4411 [KO Validated] CRMP2/DPYSL2 Rabbit mAb WB,IF Human, Mouse, Rat
PGK1 A12686 PGK1 Rabbit mAb WB Human, Mouse, Rat
A14039 PGK1 Rabbit pAb WB, IHC Human, Mouse, Rat
EHD2 A12945 EHD2 Rabbit pAb WB Human,Mouse,Rat
CAVIN1 A18331 PTRF Rabbit pAb WB,IHC,IF Human,Mouse,Rat
FGGY A14904 FGGY Rabbit pAb WB Human,Mouse,Rat
CD36 A19016 CD36/SR-B3 Rabbit mAb WB Mouse,Rat
A5792 CD36/SR-B3 Rabbit pAb WB Human,Mouse,Rat
胰腺癌血浆外泌体标志物 CA2 A9148 Carbonic Anhydrase 2 (CA2) Rabbit mAb WB,IHC Human,Mouse,Rat
CD55 A11283 CD55 Rabbit mAb WB,IHC Human
A21942 ABflo™ 488 Rabbit anti-Human CD55 mAb FC Human
A21943 ABflo™ 647 Rabbit anti-Human CD55 mAb FC Human
A1228 CD55 Rabbit pAb WB,IF Human,Mouse
KRAS A1190 KRAS Rabbit pAb WB,IHC,IF Human,Mouse,Rat
A12704 [KO Validated] KRAS Rabbit pAb WB,IF Human,Mouse,Rat
PEBP1 A12768 PEBP1 Rabbit mAb WB Human,Mouse,Rat
A0578 PEBP1 Rabbit pAb WB,IF,IP Human,Mouse,Rat
SRI A19921 [KO Validated] SRI Rabbit pAb WB,IHC,IF Human,Mouse,Rat
A6751 [KO Validated] SRI Rabbit pAb WB,IHC,IF Human,Mouse,Rat
TGM2 A21184 Transglutaminase 2 (TGM2) Rabbit mAb WB,IHC Human
A0981 TGM2 Rabbit pAb WB,IHC,IF Human,Mouse,Rat
PSMA4 A2511 PSMA4 Rabbit pAb WB,IF,IP Human,Mouse,Rat
XPNPEP2 A10255 XPNPEP2 Rabbit pAb WB Human,Mouse,Rat
ABCB11 A8467 ABCB11 Rabbit pAb WB,IF Human,Mouse,Rat
ALPL A0514 Alkaline Phosphatase (ALPL) Rabbit mAb WB,IHC Human,Mouse,Rat
A1080 Alkaline Phosphatase (ALPL) Rabbit pAb WB,IHC Human,Mouse,Rat
A12396 Alkaline Phosphatase (ALPL) Rabbit pAb WB,IHC Human,Mouse,Rat
ABCB1 A19093 P Glycoprotein Rabbit mAb WB,IHC Human,Mouse,Rat
A11747 P Glycoprotein Rabbit pAb WB Human,Mouse
A1284 P Glycoprotein Rabbit pAb WB,IF Human,Mouse,Rat
肺腺癌血浆外泌体标志物 CFB A21793 Complement factor B (CFB) Rabbit mAb WB,IF Human,Mouse
A1706 Complement factor B (CFB) Rabbit pAb WB,IHC,IF Human,Mouse,Rat
CD53 A10079 CD53 Rabbit pAb WB Human,Mouse
PRSS1 A1242 PRSS1 Rabbit pAb WB,IHC Human,Mouse
RDX A14777 Radixin Rabbit pAb WB Human,Mouse,Rat
Radixin A19751 Radixin Rabbit mAb WB Human,Mouse,Rat
CHMP4B A7402 CHMP4B Rabbit pAb WB,IF Human,Mouse,Rat
PSMB1 A1043 PSMB1 Rabbit pAb WB,IF Human,Mouse,Rat
ACTA2 A17910 α-Smooth Muscle Actin (ACTA2) Rabbit mAb WB,IHC,IF Human,Mouse,Rat
A1011 α-Smooth Muscle Actin (ACTA2) Rabbit pAb WB,IHC,IF Human,Mouse,Rat
H2A.Z A6614 [KO Validated] Histone H2A.Z Rabbit pAb WB Human,Mouse,Rat
A12442 [KO Validated] Histone H2A.Z Rabbit pAb WB Human,Mouse,Rat
神经母细胞瘤血浆外泌体标志物 FTH1 A19544 Ferritin Heavy Chain Rabbit mAb WB,IHC Human,Mouse,Rat
A1144 Ferritin Heavy Chain Rabbit pAb WB,IHC,IF Human,Mouse,Rat
KRT17 A3769 Cytokeratin 17 (KRT17) Rabbit mAb WB Human
A0123 Cytokeratin 17 (KRT17) Rabbit mAb WB,IF Human,Mouse
A2175 Cytokeratin 17 (KRT17) Rabbit mAb WB,IF Human
H3F3A A4835 Histone H3.3 Rabbit mAb WB,IHC,ChIP Human,Mouse,Rat,Other (Wide Range)
A13824 Histone H3.3 Rabbit pAb WB Human,Mouse,Rat,Other (Wide Range)
CD14 A19011 CD14 Rabbit mAb WB,IHC,IF,FC Human,Mouse
A5737 CD14 Rabbit pAb WB,IF Human,Mouse,Rat
EPB42 A17481 EPB42 Rabbit pAb WB Human,Mouse
KRT8 A1024 Cytokeratin 8 Rabbit pAb WB,IHC,IF Human,Mouse,Rat
骨肉瘤血浆外泌体标志物 ACTA1 A2235 α-Actin-1 (ACTA1) Rabbit mAb WB,IHC,IF Human,Mouse,Rat
A2280 α-Actin-1 (ACTA1) Rabbit mAb WB,IF Human,Mouse,Rat
A2319 α-Actin-1 (ACTA1) Rabbit mAb WB,IF Human,Mouse,Rat
MME/CD10 A22179 CD10/MME Rabbit mAb WB,IHC Human
A19007 CD10/MME Rabbit mAb WB Human,Mouse,Rat
A5664 CD10/MME Rabbit pAb WB,IHC Human,Mouse,Rat
乳腺癌血清外泌体标志物 AnxA2 A11235 Annexin A2 Rabbit mAb WB, IHC Human, Mouse, Rat
CD82 A9264 CD82 Rabbit mAb WB, IHC, IF Human, Mouse
前列腺癌尿液外泌体标志物 PSMA A9547 PSMA/FOLH1 Rabbit mAb WB, IF Human, Rat
黑色素瘤血液外泌体标志物 Caveolin1 A19006 Caveolin-1 Rabbit mAb WB,IHC,IF Human, Mouse, Rat
Hsp70 A12948 HSP70/HSPA1 Rabbit pAb WB, IHC, IF Human, Mouse, Rat
膀胱癌尿液外泌体标志物 TACSTD2 A20824 TROP-2 Rabbit mAb WB,IHC,IF,FC Human, Mouse, Rat
A8129 TROP-2 Rabbit mAb WB,IHC,IF Human, Mouse, Rat
MUC4 A3438 MUC4 Rabbit mAb WB, IHC Human, Rat
MUC1 A19081 MUC1 Rabbit mAb WB, IHC Human, Mouse, Rat
更多产品查询,请访问ABclonal官网:https://abclonal.com.cn/catalog-antibodies

神经系统疾病外泌体生物标志物

神经系统中的许多细胞,如少突胶质细胞、神经元和星形胶质细胞,已被证明可以释放外泌体[5]。外泌体在阿尔兹海默症 (AD)、帕金森病(PD)、卒中等多种中枢神经系统疾病中发挥着积极或负面影响。源自中枢神经系统的外泌体存在于脑脊液和外周血中,其含量会随着疾病的发生而变化。外泌体可以穿透血脑屏障并且高度稳定,在外周循环中它们可以很好地保护疾病相关分子。因此,使用外泌体作为中枢神经系统疾病的生物标志物是极具前景的,因为它们可用于监测疾病发展并实现早期诊断和治疗方案优化[6]。

神经系统疾病外泌体生物标志物相关抗体
疾病类型 来源 靶点 产品货号 产品名称 产品应用 反应物种
阿尔兹海默症 血液 GAP43 A19055 GAP43 Rabbit mAb WB, IF Human, Mouse, Rat
Neurogranin /NRGN A8444 NRGN Rabbit pAb WB Human, Mouse, Rat
SNAP25 A0986 SNAP25 Rabbit pAb WB, IHC, IF Human, Mouse, Rat
Phospho-Tau-T181 AP1234 Phospho-Tau-T181 Rabbit pAb WB Human, Mouse
Synaptotagmin-1/SYT1 A0992 SYT1 Rabbit pAb WB, IF Human, Mouse, Rat
血浆 REST/NRSF A2415 REST/NRSF Rabbit mAb WB,IP Human, Mouse, Rat
HSF1 A13765 HSF1 Rabbit pAb WB, IHC, IF Human, Mouse, Rat
LAMP1 A16894 LAMP1 Rabbit pAb WB, IHC, IF Human, Mouse, Rat
脑脊液/血清/血浆 Alpha-1 Antichymotrypsin A11364 Alpha-1 Antichymotrypsin (SERPINA3) Rabbit mAb WB Human
A2803 Alpha-1 Antichymotrypsin (SERPINA3) Rabbit pAb WB, IHC Human
帕金森 脑脊液/血浆 α-Synuclein A20407 α-Synuclein Rabbit mAb WB, IHC, IF Human, Mouse, Rat
DJ-1/PARK7 A19097 DJ-1/PARK7 Rabbit mAb WB Human, Mouse, Rat
A18580 DJ-1/PARK7 Rabbit pAb WB, IHC, IF Human, Mouse, Rat
血浆 clusterin/CLU A21104 Clusterin alpha chain Rabbit mAb WB, IHC Human, Mouse
A13479 Clusterin alpha chain Rabbit pAb WB, IHC, IF Human, Mouse, Rat
卒中 外周血 Cystatin C A8933 Cystatin C Rabbit mAb WB Human, Mouse
CD14 A19011 CD14 Rabbit mAb WB, IHC, IF Human, Mouse
CD41/ITGA2B A11490 CD41/ITGA2B Rabbit mAb WB, IHC Human, Mouse, Rat
血清 Caspase-1 A0964 Caspase-1 Rabbit pAb WB, IHC, IF, IP Human, Mouse, Rat

心血管疾病外泌体生物标志物

在心血管系统中,外泌体与内皮细胞、心肌细胞、血管细胞、干细胞和祖细胞相关,并在心血管系统的发育、损伤和疾病中发挥重要作用[7]。近年来,越来越多的证据表明外泌体参与了心血管疾病的发展和进展[8]。除了可以被邻近细胞所摄取,心血管系统的各种细胞产生的外泌体还被释放到体液中,其中包含有特征性生物标志物,为心血管疾病病理状态监测和早期干预提供更加全面精准的信息[7-9]。

心血管疾病不同阶段细胞外囊泡生物标志物[8]
来源 存在心血管疾病危险因素 动脉粥样硬化 冠状动脉疾病 不稳定斑块出现 急性冠脉综合征
内皮细胞来源外泌体 CD144+
CD31+/cd41-
Annexin+/
CD105+
CD31+/CD42-
CD31+/CD41-
CD144+/CD42b-
Annexin V+/
CD31+/CD41-
Annexin V+/
CD31+Annexin V+CD146+
CD31+/CD42-
血小板来源外泌体 CD31+/
CD41+
Annexin+/
GPIb+
CD31+/
CD42+
Annexin V+/
CD31+
/CD42+
AnnexinV+/
GPIb+
CD31+/
CD42+
白细胞来源外泌体 Annexin V+/
CD45+
Annexin V+/CD14+
Annexin+/
CD11a+
CD11b+/
CD66+
CD15+
Annexin V+/
CD11a+
Annexin V+
CD3+
红细胞来源外泌体 Annexin V+/
CD235a+
心血管疾病外泌体生物标志物相关抗体
分类 靶点 产品货号 产品名称 产品应用 反应种属
冠状动脉疾病外泌体相关生物标志物 CD144/CDH5 A12416 CDH5 Rabbit pAb WB, IHC, IP Human, Mouse, Rat
CD31/PECAM1 A20228 CD31/PECAM1 Rabbit mAb WB, IHC, IP Human
A19014 CD31/PECAM1 Rabbit mAb WB, IHC Human
A18643 CD31/PECAM1 Rabbit mAb WB,IF,IP Human
A4900 CD31/PECAM1 Rabbit mAb WB,IHC,IF Human,Mouse
CD41/ITGA2B A11490 CD41/ITGA2B Rabbit mAb WB, IHC Human, Mouse, Rat
Annexin V A9262 Annexin A5/Annexin V Rabbit mAb WB Human, Mouse, Rat
CD45 A19021 CD45 Rabbit mAb WB, IHC Human
CD14 A19011 CD14 Rabbit mAb WB, IHC, IF Human, Mouse
CD105/Endoglin A19008 CD105/Endoglin Rabbit mAb WB, IHC Human
CD11a/LFA-1A/ITGAL A19009 CD11a/LFA-1A/ITGAL Rabbit mAb WB, IHC Human
CD11b A19010 CD11b/ITGAM Rabbit mAb WB, IHC Human
CD146 A9703 CD146/MCAM Rabbit mAb WB, IHC Human, Mouse, Rat
CD3E A19017 CD3E Rabbit mAb WB, IHC Human

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