肿瘤免疫检查点

免疫检查点（Immune Checkpoint）是一类免疫抑制性分子，在免疫细胞上表达，能调节免疫激活程度，对防止自身免疫作用的发生具有重要作用。免疫检查点的免疫疗法就是通过共抑制（Co-inhibitory）或共刺激（Co-stimulatory）信号等一系列途径以调节T细胞活性来杀伤肿瘤细胞的治疗方法。免疫检查点分子使免疫系统活化时能够保持在正常的范围之内，维持机体免疫稳态。过度的免疫反应会导致炎症组织损伤和自身免疫性疾病，而受到压制的免疫反应与多种肿瘤发生发展密切相关。

关键研究靶点
分类 靶点 产品名称 货号
共刺激分子 CD27 CD27 Rabbit mAb A11505
共刺激分子 CD27 ABflo® 488 Rabbit anti-Human CD27 mAb A22063
共刺激分子 CD27 ABflo® 647 Rabbit anti-Human CD27 mAb A22064
共刺激分子 CD28 CD28 Rabbit mAb A20346
共刺激分子 CD40 CD40 Rabbit mAb A20214
共刺激分子 CD40 ABflo® 488 Rabbit anti-Human CD40 mAb A21938
共刺激分子 CD40 ABflo® 647 Rabbit anti-Human CD40 mAb A21947
共刺激分子 CD70/CD27L/TNFSF7 CD70 Rabbit mAb A20589
共刺激分子 CD70/CD27L/TNFSF7 ABflo® 488 Rabbit anti-Human CD70 mAb A22302
共刺激分子 CD70/CD27L/TNFSF7 ABflo® 647 Rabbit anti-Human CD70 mAb A22303
共刺激分子 CD86 CD86 Rabbit mAb A21198
共刺激分子 CD86 ABflo® 488 Rabbit anti-Human CD86 mAb A21940
共刺激分子 CD86 ABflo® 647 Rabbit anti-Human CD86 mAb A21941
共刺激分子 CD155/PVR CD155/PVR Rabbit mAb A23084
共刺激分子 ICOS/AILIM/CD278 ICOS/CD278 Rabbit mAb A5130
共刺激分子 MICA MICA Rabbit mAb A19256
共抑制分子 CD47 ABflo® 488 Rabbit anti-Human CD47 mAb A24300
共抑制分子 CD47 ABflo® 594 Rabbit anti-Human CD47 mAb A24302
共抑制分子 CD47 ABflo® 647 Rabbit anti-Mouse CD47 mAb A24378
共抑制分子 CD48/SLAMF2 CD48 Rabbit mAb A4084
共抑制分子 CD48/SLAMF2 ABflo® 488 Rabbit anti-Human CD48 mAb A21937
共抑制分子 CD48/SLAMF2 ABflo® 647 Rabbit anti-Human CD48 mAb A21946
共抑制分子 CEACAM1/CD66a CEACAM1 Rabbit mAb A11626
共抑制分子 CD73 FITC Mouse anti-Human CD73 mAb A22845
共抑制分子 CD73 PE Mouse anti-Human CD73 mAb A22846
共抑制分子 CTLA-4/CD152 CD152/CTLA-4 Rabbit mAb A22865
共抑制分子 CTLA-4/CD152 PE Rabbit anti-Human CD152/CTLA-4 mAb A23713
共抑制分子 PD-L1/B7-H1/CD274 PD-L1/CD274 Rabbit mAb A19135
共抑制分子 PD-L1/B7-H1/CD274 PD-L1/CD274 Rabbit PolymAb® A23136
共抑制分子 PD-L1/B7-H1/CD274 ABflo® 488 Rabbit anti-Human PD-L1/CD274 mAb A22304
共抑制分子 PD-L1/B7-H1/CD274 ABflo® 647 Rabbit anti-Human PD-L1/CD274 mAb A22305
共抑制分子 SIGLEC3/CD33 ABflo® 488 Rabbit anti-Human CD33 mAb A22639
共抑制分子 SIGLEC3/CD33 ABflo® 647 Rabbit anti-Human CD33 mAb A22640
共抑制分子 TIM-3/HAVCR2 ABflo® 488 Rabbit anti-Human TIM-3/HAVCR2 mAb A22158
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热门抗体

A19135

PD-L1/CD274 Rabbit mAb

  • PD-L1/CD274 Rabbit mAb
  • PD-L1/CD274 Rabbit mAb
  • PD-L1/CD274 Rabbit mAb
  • PD-L1/CD274 Rabbit mAb

A22641

ABflo® 488 Rabbit anti-Human CD40 mAb

  • ABflo® 488 Rabbit anti-Human CD40 mAb
  • ABflo® 488 Rabbit anti-Human CD40 mAb
  • ABflo® 488 Rabbit anti-Human CD40 mAb
  • ABflo® 488 Rabbit anti-Human CD40 mAb

A24302

ABflo® 594 Rabbit anti-Human CD47 mAb

  • ABflo® 594 Rabbit anti-Human CD47 mAb
  • ABflo® 594 Rabbit anti-Human CD47 mAb



关键免疫检查点重组蛋白
蛋白 产品名称 物种 基因ID 货号
PD-L1 Recombinant Human B7-H1/PD-L1/CD274 Protein Human 29126 RP00068
PD-L1 Recombinant Human B7-H1/PD-L1/CD274 Protein Human 29126 RP00184
PD-L1 Recombinant Mouse B7-H1/PD-L1/CD274 Protein Mouse 60533 RP01158
PD-1 Recombinant Human PD-1/PDCD1/CD279 Protein Human 5133 RP00067
OX-2 Recombinant Human OX-2/CD200 Protein Human 4345 RP00127
CTLA-4 Recombinant Human CTLA-4/CD152 Protein Human 1493 RP01044
CD28 Recombinant Human CD28 Protein Human 940 RP00136
B7-H3 Recombinant Human B7-H3/CD276 Protein Human 80381 RP01020
B7-H5 Recombinant Mouse B7-H5/Gi24/VISTA Protein Mouse 74048 RP01328
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热门重组蛋白

RP00068

Recombinant Human B7-H1/PD-L1/CD274 Protein

  • Recombinant Human B7-H1/PD-L1/CD274 Protein
  • Recombinant Human B7-H1/PD-L1/CD274 Protein
  • Recombinant Human B7-H1/PD-L1/CD274 Protein
  • Recombinant Human B7-H1/PD-L1/CD274 Protein

RP00136

Recombinant Human CD28 Protein

  • Recombinant Human CD28 Protein
  • Recombinant Human CD28 Protein

RP01044

Recombinant Human CTLA-4/CD152 Protein

  • Recombinant Human CTLA-4/CD152 Protein
  • Recombinant Human CTLA-4/CD152 Protein
  • Recombinant Human CTLA-4/CD152 Protein
  • Recombinant Human CTLA-4/CD152 Protein
  • Recombinant Human CTLA-4/CD152 Protein