RNA biology is orchestrated by the interplay of RNAs with RNA binding proteins (RBPs) within dynamic ribonucleoproteins (RNPs) . Both the RBP repertoire and RBP activities of cells respond to a multitude of biological cues and environmental stimuli. Against this background, it is unsurprising that numerous diseases have been linked to defects in RBP expression and function, including neuropathies, muscular atrophies, metabolic disorders, and cancer.
RBPs determine RNA fate from synthesis to decay. RBPs are the primary regulatory factors of the various post-translational stages, including alternative splicing, polyadenylation, mRNA localization, translation and degradation.